The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Autophagy in cell death: an innocent convict?
Open accessAbstract
The visualization of autophagosomes in dying cells has led to the belief that autophagy is a nonapoptotic form of programmed cell death. This concept has now been evaluated using cells and organisms deficient in autophagy genes. Most evidence indicates that, at least in cells with intact apoptotic machinery, autophagy is primarily a pro-survival rather than a pro-death mechanism. This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases.
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Cites
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Self-citationThe role of autophagy during the early neonatal starvation period
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Cited by
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Self-citationMitochondrial membrane permeabilization in cell death
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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
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Self-citationLoss of autophagy in the central nervous system causes neurodegeneration in mice
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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
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Metadata
- Authors
- Levine, B.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-10-01
- Volume
- 115
- Issue
- 10
- Pages
- 2679-2688
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2145206598
- Cited by
- 1,676
- References
- 16
- FWCI
- 64.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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