The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The BTB/POZ Domain of the Arabidopsis Disease Resistance Protein NPR1 Interacts with the Repression Domain of TGA2 to Negate Its Function
Open accessAbstract
TGA2 and NONEXPRESSER OF PR GENES1 (NPR1) are activators of systemic acquired resistance (SAR) and of the SAR marker gene pathogenesis-related-1 (PR-1) in Arabidopsis thaliana. TGA2 is a transcriptional repressor required for basal repression of PR-1, but during SAR, TGA2 recruits NPR1 as part of an enhanceosome. Transactivation by the enhanceosome requires the NPR1 BTB/POZ domain. However, the NPR1 BTB/POZ domain does not contain an autonomous transactivation domain; thus, its molecular role within the enhanceosome remains elusive. We now show by gel filtration analyses that TGA2 binds DNA as a dimer, tetramer, or oligomer. Using in vivo plant transcription assays, we localize the repression domain of TGA2 to the N terminus and demonstrate that this domain is responsible for modulating the DNA binding activity of the oligomer both in vitro and in vivo. We confirm that the NPR1 BTB/POZ domain interacts with and negates the molecular function of the TGA2 repression domain by excluding TGA2 oligomers from cognate DNA. These data distinguish the NPR1 BTB/POZ domain from other known BTB/POZ domains and establish its molecular role in the context of the Arabidopsis PR-1 gene enhanceosome.
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Citations
Cites
Sequence and structural analysis of BTB domain proteins
Stogios, P. J., Downs, G. S., Jauhal, J. J., Nandra, S. K., & Privé, G. G. (2005) · Genome Biology · doi:10.1186/gb-2005-6-10-r82 · Cited by 694 · cited 2×
“Stogios, P.J., Downs, G.S., Jauhal, J.J., Nandra, S.K., and Prive, G.G. (2005).”
Cited by
Argout, X., Salse, J., Aury, J.-M., Guiltinan, M. J., Droc, G., Gouzy, J., Allegre, M., Chaparro, C., Legavre, T., Maximova, S. N., et al. (2011) · Nature Genetics · doi:10.1038/ng.736 · Cited by 746
CRISPR/Cas9-Mediated SlNPR1 mutagenesis reduces tomato plant drought tolerance
Li, R., Liu, C., Zhao, R., Wang, L., Chen, L., Yu, W., Zhang, S., Sheng, J., & Shen, L. (2019) · BMC Plant Biology · doi:10.1186/s12870-018-1627-4 · Cited by 266
BLADE-ON-PETIOLE genes: Setting boundaries in development and defense
Khan, M., Xu, H., & Hepworth, S. R. (2014) · Plant Science · doi:10.1016/j.plantsci.2013.10.019 · Cited by 81
Metadata
- Authors
- Boyle, P., Le Su, E., Rochon, A., Shearer, H. L., Murmu, J., Chu, J. Y., Fobert, P. R., & Després, C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-11-01
- Volume
- 21
- Issue
- 11
- Pages
- 3700-3713
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2165346074
- Cited by
- 176
- References
- 1
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Boyle, P., Le Su, E., Rochon, A., Shearer, H. L., Murmu, J., Chu, J. Y., Fobert, P. R., & Després, C. (2009). The BTB/POZ Domain of the Arabidopsis Disease Resistance Protein NPR1 Interacts with the Repression Domain of TGA2 to Negate Its Function. The Plant Cell. https://doi.org/10.1105/tpc.109.069971
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