The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
bZIP28 and NF-Y Transcription Factors Are Activated by ER Stress and Assemble into a Transcriptional Complex to Regulate Stress Response Genes in Arabidopsis
Open accessAbstract
Stress agents known to elicit the unfolded protein response in Arabidopsis thaliana upregulate the expression of a constellation of genes dependent on the membrane-associated basic domain/leucine zipper (bZIP) transcription factor, bZIP28. Among the stress-activated genes, a consensus promoter sequence corresponding to the endoplasmic reticulum (ER) stress-responsive element I (ERSE-I), CCAAT-N10-CACG, was identified. Disruption of either the CCAAT or CACG subelement in ERSE-I resulted in reduction of the transcriptional response to ER stress. bZIP28 forms homo- and heterodimers with other bZIP TF family members (in subgroup D) and interacts with CCAAT box binding factors, heterotrimeric factors composed of NF-Y subunits. Arabidopsis encodes 36 NF-Y subunits, and it was found that subunits NF-YB3 and -YC2 interact with bZIP28 and NF-YA4, respectively, in a yeast three-hybrid system. A transcriptional complex containing bZIP28 and the above-mentioned three NF-Y subunits was assembled in vitro on DNA containing ERSE-I. bZIP28, on its own, binds to the CACG subelement in ERSE-I to form a smaller complex I, and in combination with the NF-Y subunits above, bZIP28 assembles into a larger transcriptional complex (complex II). bZIP28 was shown to interact with NF-Y subunits in vivo in bimolecular fluorescence complementation analyses and in coimmunoprecipitation assays. Treatment of seedlings with ER stress agents led to the upregulation of NF-YC2 and the relocation of NF-YB3 from the cytoplasm to the nucleus. Thus, in response to ER stress, bZIP28 is mobilized by proteolysis and recruits NF-Y subunits to form a transcriptional complex that upregulates the expression of ER stress-induced genes.
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Cites
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Cited by
Breeze, E., Harrison, E., McHattie, S., Hughes, L., Hickman, R., Hill, C., Kiddle, S., Kim, Y.-S., Penfold, C. A., Jenkins, D., et al. (2011) · The Plant Cell · doi:10.1105/tpc.111.083345 · Cited by 868
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Howell, S. H. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120053 · Cited by 560
Self-citationCCAAT-box binding transcription factors in plants: Y so many?
Laloum, T., De Mita, S., Gamas, P., Baudin, M., & Niebel, A. (2013) · Trends in Plant Science · doi:10.1016/j.tplants.2012.07.004 · Cited by 381
Perspectives on deciphering mechanisms underlying plant heat stress response and thermotolerance
Bokszczanin, K. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00315 · Cited by 353
Cao, S., Kumimoto, R. W., Gnesutta, N., Calogero, A. M., Mantovani, R., & Holt, B. F. (2014) · The Plant Cell · doi:10.1105/tpc.113.120352 · Cited by 294
Metadata
- Authors
- Liu, J.-X., & Howell, S. H.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-01
- Volume
- 22
- Issue
- 3
- Pages
- 782-796
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2120074831
- Cited by
- 408
- References
- 58
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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