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Gene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses
Open accessAbstract
Previously, it was shown that the upper leaves of plants infected with nepoviruses and caulimoviruses are symptom free and contain reduced levels of virus. These leaves are said to be recovered. Recovery is associated with RNA-mediated cross-protection against secondary virus infection. Here, by analyzing plants infected with viruses that are quite distinct from the nepovirus or caulimovirus groups, we demonstrate that this RNA-mediated defense is a general response to virus infection. Upon infection with a tobravirus, plants exhibited RNA-mediated cross-protection and recovery, as occurs in nepovirus-infected plants. However, upon infection with a potexvirus, plants exhibited RNA-mediated cross-protection without recovery. In both instances, a transient gene expression assay showed that RNA-mediated cross-protection was functionally equivalent to post-transcriptional gene silencing. Combined, these data provide direct evidence that post-transcriptional gene silencing of nuclear genes is a manifestation of a natural defense mechanism that is induced by a wide range of viruses.
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Cited by
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345
Noncoding RNAs in Retrovirus Replication
Duchon, A. A., & Musier-Forsyth, K. (2018) · Retrovirus-Cell Interactions · doi:10.1016/b978-0-12-811185-7.00012-1 · Cited by 1
Metadata
- Authors
- Ratcliff, F. G., MacFarlane, S. A., & Baulcombe, D. C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07
- Volume
- 11
- Issue
- 7
- Pages
- 1207-1215
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2162396822
- Cited by
- 476
- References
- 0
- FWCI
- 49.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Ratcliff, F. G., MacFarlane, S. A., & Baulcombe, D. C. (1999). Gene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses. The Plant Cell. https://doi.org/10.1105/tpc.11.7.1207
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