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The bHLH Transcription Factor HBI1 Mediates the Trade-Off between Growth and Pathogen-Associated Molecular Pattern–Triggered Immunity in Arabidopsis
Open accessAbstract
The trade-off between growth and immunity is crucial for survival in plants. However, the mechanism underlying growth-immunity balance has remained elusive. The PRE-IBH1-HBI1 tripartite helix-loop-helix/basic helix-loop-helix module is part of a central transcription network that mediates growth regulation by several hormonal and environmental signals. Here, genome-wide analyses of HBI1 target genes show that HBI1 regulates both overlapping and unique targets compared with other DNA binding components of the network in Arabidopsis thaliana, supporting a role in specifying network outputs and fine-tuning feedback regulation. Furthermore, HBI1 negatively regulates a subset of genes involved in immunity, and pathogen-associated molecular pattern (PAMP) signals repress HBI1 transcription. Constitutive overexpression and loss-of-function experiments show that HBI1 inhibits PAMP-induced growth arrest, defense gene expression, reactive oxygen species production, and resistance to pathogen. These results show that HBI1, as a component of the central growth regulation circuit, functions as a major node of crosstalk that mediates a trade-off between growth and immunity in plants.
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Cites
BRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling
Nam, K. H., & Li, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00814-0 · Cited by 1,217
Santiago, J., Henzler, C., & Hothorn, M. (2013) · Science · doi:10.1126/science.1242468 · Cited by 357
Cited by
Evolution of Hormone Signaling Networks in Plant Defense
Berens, M. L., Berry, H. M., Mine, A., Argueso, C. T., & Tsuda, K. (2017) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080516-035544 · Cited by 563
Transcriptional networks in plant immunity
Tsuda, K., & Somssich, I. E. (2015) · New Phytologist · doi:10.1111/nph.13286 · Cited by 552
A single transcription factor promotes both yield and immunity in rice
Wang, J., Zhou, L., Shi, H., Chern, M., Yu, H., Yi, H., He, M., Yin, J., Zhu, X., Li, Y., et al. (2018) · Science · doi:10.1126/science.aat7675 · Cited by 493
Liu, S., Kracher, B., Ziegler, J., Birkenbihl, R. P., & Somssich, I. E. (2015) · eLife · doi:10.7554/elife.07295 · Cited by 292
Trade-off between growth and immunity: role of brassinosteroids
Lozano-Durán, R., & Zipfel, C. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2014.09.003 · Cited by 262
Metadata
- Authors
- Fan, M., Bai, M.-Y., Kim, J.-G., Wang, T., Oh, E., Chen, L., Park, C. H., Son, S.-H., Kim, S.-K., Mudgett, M. B., & Wang, Z.-Y.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-02-01
- Volume
- 26
- Issue
- 2
- Pages
- 828-841
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2120746999
- Cited by
- 237
- References
- 2
- FWCI
- 24.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fan, M., Bai, M.-Y., Kim, J.-G., Wang, T., Oh, E., Chen, L., Park, C. H., Son, S.-H., Kim, S.-K., Mudgett, M. B., & Wang, Z.-Y. (2014). The bHLH Transcription Factor HBI1 Mediates the Trade-Off between Growth and Pathogen-Associated Molecular Pattern–Triggered Immunity in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.113.121111
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