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Recent developments in classical density modification

Open access
Cowtan, Kevin·2010·Acta Crystallographica Section D Biological Crystallography

Abstract

Classical density-modification techniques (as opposed to statistical approaches) offer a computationally cheap method for improving phase estimates in order to provide a good electron-density map for model building. The rise of statistical methods has lead to a shift in focus away from the classical approaches; as a result, some recent developments have not made their way into classical density-modification software. This paper describes the application of some recent techniques, including most importantly the use of prior phase information in the likelihood estimation of phase errors within a classical density-modification framework. The resulting software gives significantly better results than comparable classical methods, while remaining nearly two orders of magnitude faster than statistical methods.

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Metadata

Authors
Cowtan, K.
Venue
Acta Crystallographica Section D Biological Crystallography
Published
2010-03-24
Volume
66
Issue
4
Pages
470-478
ISSN
0907-4449 (ISSN-L)
OpenAlex
W2111482169
Cited by
420
References
1
FWCI
11.89
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Recent developments in classical density modification. https://app.cochat.ai/papers/10.1107/s090744490903947x
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Cowtan, K. (2010). Recent developments in classical density modification. Acta Crystallographica Section D Biological Crystallography. https://doi.org/10.1107/s090744490903947x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.