Fabrication of synthesized PCL‐PEG‐PCL tissue engineering scaffolds using an air pressure‐aided deposition system
Abstract
Purpose – Bone tissue engineering is an emerging field providing viable substitutes for bone regeneration. Poly(ε‐caprolactone) (PCL) is a good candidate for scaffold fabrication due to its high mechanical strength and excellent resistance under moist conditions, but its hydrophobicity causes cell‐attached difficulties, thus limiting its clinical application. The paper aims to develop an air pressure‐aided deposition system for fabricating scaffolds made of synthesized PCL‐PEG‐PCL copolymers and to validate the biocompatibility and hydrophilicity improvement of fabricated scaffolds.
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PEG is nontoxic and water-soluble and is often used for copolymerization or blending with PCL matrix to improve the hydrophilicity of PCL-based 3D printed scaffolds.
“As a nontoxic and water-soluble polymer, poly (ethylene glycol) (PEG) is often used for copolymerization or blending with PCL matrix to improve the hydrophilicity of PCL-based 3D printed scaffolds, and some interesting results have been achieved [35][36][37]”
From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [37]
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Method
- Authors
- Jiang, C., Huang, J., & Hsieh, M.
- Affiliations
- National Formosa University (TW)
- Chung Yuan Christian University (TW)
- Venue
- Rapid Prototyping Journal
- Publisher
- Emerald
- Published
- 2011-06-14
- Volume
- 17
- Issue
- 4
- Pages
- 288-297
- ISSN
- 1355-2546 (ISSN-L)
- OpenAlex
- W2079927716
- Cited by
- 38
- References
- 23
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 3
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rapid Prototyping Journal (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- tissue engineering scaffolds, bone tissue engineering, bone regeneration, polycaprolactone, biocompatibility, scaffold fabrication
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