Cited by 192Neuroscience and Neural EngineeringNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Simultaneous measurement of intracellular calcium and electrical activity from patterned neural networks in culture

Jimbo, Y., Robinson, H.P.C., Kawana, A.·1993·IEEE Transactions on Biomedical Engineering

DOI 10.1109/10.238465

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Abstract

Multisite extracellular electrical activity and intracellular calcium were recorded simultaneously. Electrical signals were measured using microelectrode array substrates. A novel cell positioning technique was combined with a method for controlling neurite outgrowth, which allowed cell-electrode contacts to be established easily, thus facilitating the electrical recording. Intracellular calcium was measured optically using the indicator fluo 3. Under low-magnesium conditions, cultured rat cortical neurons showed periodic transients of fluo-3 fluorescence, which were synchronized with the periodic bursting observed electrically. The intervals between bursts could be determined by electrical stimulation through the substrate electrodes. The results suggest that functional synaptic connections are formed in the culture system.

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“Early work in this field was done by Jimbo et al. (1993) .”
Background
Properties of the Evoked Spatio-Temporal Electrical Activity in Neuronal Assemblies
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“At present, this technique is being developed in several laboratories [3, 4], including ours [5], and shows great promise to become a new powerful tool for in vitro testing of experimental conditions somehow related to in vivo ones .”
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Background
Parallel multipoint recording of aligned and cultured neurons on micro channel array toward cellular network analysis
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MethodSelf-citation
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BackgroundMethod
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Background
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“The same group later reported the simultaneous recording of electrical activity and intracellular [Ca2+] using fluorescent dyes, showing the combination of optical and electrical techniques (Jimbo et al. (1993)). www.intechopen.com”
Method
Bioassay using living cells integrated on a chip
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Method
Development of a Neural Interface for PNS Motor Control
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“Generally speaking, these techniques can be divided into two groups based on mechanism: 1) mechanically-based techniques, in which the topography of the electrode itself is in some way modified to cause directed cell adhesion or neurite outgrowth [81, 84] and 2) chemically-based techniques, in which chemical guidance…”
BackgroundMethod
Site-selective Electrical Recording from Small Neuronal Circuits using Spray Patterning Method and Mobile Microelectrodes
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Background
Vitroid - a robot with link between living neuronal network in vitro and robot body
Kudoh, S. N., Tokuda, M., Kiyohara, A., Hosokawa, C., Taguchi, T., & Hayashi, I. (2008) · IEEE International Conference on Mechatronics and Automation (ICMA) · doi:10.1109/icma.2008.4798783 · Cited by 2
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Method
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“Chip preparation followed previous protocol [22], [23].”
Electrical recordings with gold coated microelectrode arrays that permit the control of neuronal attachment
Nam, Y., Wheeler, B. C., & Brewer, G. (2002) · Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology · doi:10.1109/iembs.2002.1053200 · Cited by 1
A study on culturing of neurons on micro-electrode array in hybrid retinal implant
Ito, Y., Yagi, T., Kanda, H., Tanaka, S., Watanabe, M., & Ushikawa, Y. (1999) · ICONIP'99. ANZIIS'99 & ANNES'99 & ACNN'99. 6th International Conference on Neural Information Processing. Proceedings (Cat. No.99EX378) · doi:10.1109/iconip.1999.844018 · Cited by 1
“of axons were emulated along the ditches which were fabricated on an electrode array [ 8 ].”
Method
Des cellules et des puces
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Background
Site-Selective Recording of Spontaneous Activity from Cultured Small Neuronal Circuits by Means of Spray-Patterning and a Mobile Microelectrode
Moriguchi, H., Tamai, N., Takayama, Y., Kurashima, T., & Jimbo, Y. (2007) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.127.1562 · Cited by 1
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Self-citation
Emergence of Deviance Detection in Cortical Cultures Through Maturation, Criticality, and Early Experience
Zhang, Z. D., Yaron, A., Akita, D., Shiramatsu, T., Chao, Z. C., & Takahashi, H. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70706
“…Scientific), horse serum (Cytiva, Marlborough, MA, USA), GlutaMAX (Thermo Fisher Scientific), and sodium pyruvate (Thermo Fisher Scientific), as described previously (Jimbo et al. 1993; Potter and DeMarse 2001; Yada et al. 2016, 2017; Kubota et al. 2019; Ikeda et al. 2025; Zhang et al. 2025).”
Hardware Acceleration of a Dielectrophoresis System for Achieving a Single-Neuron-Per-Electrode Arrangement in Microelectrode Arrays
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Discussion about “synthetic intelligence” in dissociated culture system
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Authors: Jimbo, Y., Robinson, H. P. C., & Kawana, A.
Affiliations: NTT (Japan) (JP)
ORCID: Jimbo, Y.
Robinson, H.P.C.
Venue: IEEE Transactions on Biomedical Engineering
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Published: 1993
Volume: 40
Issue: 8
Pages: 804-810
ISSN: 0018-9294 (ISSN-L)
DOI: 10.1109/10.238465
OpenAlex: W2051002031
Cited by: 192
References: 0
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 1 · 2014: 5 · 2013: 8 · 2012: 3
FWCI: 1.43
Type: journal article
Language: en
Open access: closed
Licence: ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations: IEEE Transactions on Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: intracellular calcium, microelectrode arrays, fluo-3, cortical neurons, neuronal bursting, electrical stimulation, cell positioning, synaptic connectivity, simultaneous recording
MeSH terms: Animals, Calcium, Cells, Cultured, Cerebral Cortex, Cytological Techniques, Electric Stimulation, Electrophysiology, Embryo, Mammalian, Equipment Design, Magnesium, Microelectrodes, Nerve Net, Neurons, Semiconductors, Rats

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Simultaneous measurement of intracellular calcium and electrical activity from patterned neural networks in culture

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