Cited by 1,913COVID-19 diagnosis using AIArtificial Intelligence in Healthcare and EducationSARS-CoV-2 detection and testing

The DOI matches its Crossref record; 64 of the 72 references it cites were found in a registry or an index; none of the 21 sources its claims cite is checked for support yet.

Can AI Help in Screening Viral and COVID-19 Pneumonia?

Open access

Abstract

Coronavirus disease (COVID-19) is a pandemic disease, which has already caused thousands of causalities and infected several millions of people worldwide. Any technological tool enabling rapid screening of the COVID-19 infection with high accuracy can be crucially helpful to the healthcare professionals. The main clinical tool currently in use for the diagnosis of COVID-19 is the Reverse transcription polymerase chain reaction (RT-PCR), which is expensive, less-sensitive and requires specialized medical personnel. X-ray imaging is an easily accessible tool that can be an excellent alternative in the COVID-19 diagnosis. This research was taken to investigate the utility of artificial intelligence (AI) in the rapid and accurate detection of COVID-19 from chest X-ray images. The aim of this paper is to propose a robust technique for automatic detection of COVID-19 pneumonia from digital chest X-ray images applying pre-trained deep-learning algorithms while maximizing the detection accuracy. A public database was created by the authors combining several public databases and also by collecting images from recently published articles. The database contains a mixture of 423 COVID-19, 1485 viral pneumonia, and 1579 normal chest X-ray images. Transfer learning technique was used with the help of image augmentation to train and validate several pre-trained deep Convolutional Neural Networks (CNNs). The networks were trained to classify two different schemes: i) normal and COVID-19 pneumonia; ii) normal, viral and COVID-19 pneumonia with and without image augmentation. The classification accuracy, precision, sensitivity, and specificity for both the schemes were 99.7%, 99.7%, 99.7% and 99.55% and 97.9%, 97.95%, 97.9%, and 98.8%, respectively. The high accuracy of this computer-aided diagnostic tool can significantly improve the speed and accuracy of COVID-19 diagnosis. This would be extremely useful in this pandemic where disease burden and need for preventive measures are at odds with available resources.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

This paper proposes transfer learning with pre-trained CNNs to detect COVID-19 pneumonia from chest X-ray images, using a newly assembled public database of 423 COVID-19, 1,485 viral pneumonia, and 1,579 normal images. It reports very high classification performance, especially for DenseNet201 with image augmentation in the three-class task.

Key findings

  • For two-class classification (normal vs. COVID-19 pneumonia), the reported accuracy, precision, sensitivity, and specificity were 99.7%, 99.7%, 99.7%, and 99.55%, respectively.
  • For three-class classification (normal, viral pneumonia, and COVID-19 pneumonia), the reported accuracy, precision, sensitivity, and specificity were 97.9%, 97.95%, 97.9%, and 98.8%, respectively.
  • CheXNet achieved the highest two-class accuracy of 99.4% without augmentation and 99.7% with augmentation; DenseNet201 outperformed other models in the three-class scheme when image augmentation was used.
  • In the DenseNet201 confusion matrix with augmentation, only 3 of 423 COVID-19 images were misclassified as normal in the two-class problem, and only 1 COVID-19 image was misclassified as normal in the three-class problem.

Methods

  • The authors created a public database by combining several public sources and collecting images from published articles: 423 COVID-19, 1,485 viral pneumonia, and 1,579 normal chest X-ray images.
  • Eight pre-trained CNNs were trained, validated, and tested using transfer learning: MobileNetv2, SqueezeNet, ResNet18, ResNet101, DenseNet201, CheXNet, Inceptionv3, and VGG19.
  • Two classification schemes were evaluated with and without image augmentation: two-class (normal vs. COVID-19) and three-class (normal, viral pneumonia, and COVID-19), using stratified 5-fold cross-validation with 80% training and 20% test splits.

Limitations

  • The paper does not include a dedicated limitations section; it states that three COVID-19 images were misclassified and that cases without evident light-focus edge features in deep layers “have to be confirmed by other techniques.”
  • The paper notes that results reported on smaller databases in the literature should be evaluated on a large dataset to be generalizable.
  • Evident from the text: the study uses a retrospectively assembled public/image-article dataset rather than a prospective clinical cohort, and no external validation cohort or full reader study is described; only three misclassified images were evaluated by three practicing radiologists.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1109/access.2020.3010287

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Verification

Claims the paper makes

0 of 21 cited sources checked · 0 supported · 0 flagged

Show all 35 claims

  • It may state two separate claims as one. 34
  • The quote only partly states this claim. 1
  • Probably not a substantial claim. 11
41 of 41
  • The paper relies on this without support.

    Deep convolutional neural networks typically perform better with a larger dataset than a smaller one.

    “Deep convolutional neural networks typically perform better with a larger dataset than a smaller one.”
  • The paper relies on this without support.

    The number of chest X-ray images publicly available online is small and scattered.

    “Although there are a large number of COVID-19 patients infected worldwide, the number of chest X-ray images publicly available online are small and scattered.”
  • The paper relies on this without support.

    COVID-19 X-ray images are significantly different from normal images.

    “as the COVID-19 images are significantly different from normal images all the tested networks are performing well.”
  • The paper relies on this without support.

    Images of various viral pneumonias are similar and overlap with other infectious and inflammatory lung diseases.

    “the images of various viral pneumonias are similar and they overlap with other infectious and inflammatory lung diseases.”
  • The paper relies on this without support.

    The symptoms of COVID-19 are similar to those of viral pneumonia.

    “The symptoms of COVID-19 being similar to that of viral pneumonia”
  • The paper relies on this without support.

    CheXNet was originally trained on a very large X-ray image dataset.

    “CheXNet was originally trained one a very large X-ray image dataset.”
    “CheXNet was pre-trained on a large X-ray database”
  • The paper relies on this without support.

    There is a large degree of variability in the input images from X-ray machines due to variations in the expertise of the radiologist.

    “Moreover, there is a large degree of variability in the input images from the X-ray machines due to the variations of expertise of the radiologist.”
  • The paper relies on this without support.

    The evaluations of the three practicing radiologists are reliable for identifying signs of COVID-19 in the miss-classified images.

    “These three images were evaluated by three practicing radiologists to identify what is their evaluations for these three images.”
  • The paper relies on this without support.

    Doctor's time is limited because a large number of patients attend out-door or emergency.

    “Since a large number of patients attending out-door or emergency, doctor's time is limited”
9 of 9

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Citation [51] does not identify the Khan study

    Minor

    The text cites [51] for Khan et al.'s study, but reference [51] lists Ucar and Korkmaz; the Khan et al. paper is listed at [56].

  • Thread-reader dataset cites an unrelated reference

    Minor

    The dataset description cites [64] for the Spanish physician's thread-reader images, but reference [64] is a ChestX-ray8 database paper.

  • Citation [47] does not identify the Ucar study

    Minor

    The text cites [47] for Ucar et al.'s SqueezeNet work, but reference [47] is a paper by Zhang et al.; the Ucar and Korkmaz paper is listed at [51].

  • COVID-CAPS is attributed to the wrong reference

    Minor

    The text cites [43] for COVID-CAPS, whereas reference [43] is by Apostolopoulos and Mpesiana; the COVID-CAPS paper appears at [49].

  • Citation [39] does not identify the Ioannis study

    Minor

    The text attributes a COVID-19 classification study to Ioannis et al. at [39], but reference [39] is a paper by Lakhani and Sundaram on tuberculosis.

5 of 5

Citations

Cites

Flagged first, then by citations

Show all 72 references

8 of the 72 references couldn’t be matched to a known paper.

Research works printed but not linked: 18

  1. weinstock, 2020, Chest X-ray findings in 636 ambulatory patients with COVID-19 presenting to an urgent care center: A normal chest X-ray is no guarantee, J Urgent Care Med, 14, 8
  2. gershgorn, 2017, The Data that Transformed AI Research-and Possibly the World
  3. muhammad, 2020, COVID-19 Chest X-Ray Database
  4. monteral, 2020, COVID-Chestxray Database
  5. radiology, 2020, COVID-19 Database
  6. 2020, Radiopedia
  7. imaging, 2020, This is a Thread of COVID-19 CXR (All SARS-CoV-2 PCR+) From my Hospital (Spain) I Hope it Could Help
  8. 10.1109/cvpr.2017.369 · DOI · Paper page
  9. mooney, 2018, Chest X-Ray Images (Pneumonia)
  10. 2020, Inception Understanding Various Architectures of Convolutional Networks
  11. 2020, Coronavirus Disease 2019 (COVID-19
  12. 2020, WHO Director-General’s Opening Remarks at the Media Briefing on COVID-19–11 March 2020
  13. medicine, 2020, Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)
  14. 2020, Global COVID-19 Report
  15. news, 2020, Bangladesh Scientists Create 3 Kit Can it Help Detect COVID-19
  16. news, 2020, India’s Poor Testing Rate May Have Masked Coronavirus Cases
  17. wetsman, 2020, Coronavirus Testing Shouldn’T Be This Complicated
  18. joaquin, 2020, Using Deep Learning to Detect Pneumonia Caused by NCOV-19 From X-Ray Images

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Metadata

Authors
Chowdhury, M. E. H., Rahman, T., Khandakar, A., Mazhar, R., Kadir, M. A., Mahbub, Z. B., Islam, K. R., Khan, M. S., Iqbal, A., Emadi, N. A., Reaz, M. B. I., & Islam, M. T.
Affiliations
  • Qatar University (QA)
  • University of Dhaka (BD)
  • Hamad General Hospital (QA)
  • North South University (BD)
  • University of Engineering and Technology Peshawar (PK)
  • National University of Malaysia (MY)
Venue
IEEE Access
Published
2020
Volume
8
Pages
132665-132676
ISSN
2169-3536 (ISSN-L)
OpenAlex
W3013277995
Cited by
1,913
References
72
Citations by year
2026: 122 · 2025: 188 · 2024: 276 · 2023: 364 · 2022: 432 · 2021: 424 · 2020: 107
FWCI
161.58
Type
journal article
Language
en
Open access
Locations
  • IEEE Access (publishedVersion, cc-by)
  • arXiv (Cornell University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • Qatar University QSpace (Qatar University) (submittedVersion)
  • arXiv (Cornell University)
Funders
Qatar National Research Fund, a member of Qatar Foundation, Doha, Qatar (NPRP12S-0227-190164)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › COVID-19 diagnosis using AI
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords
COVID-19 pneumonia, viral pneumonia, chest radiography, computer-aided diagnosis, COVID-19 screening, transfer learning, convolutional neural networks, image augmentation, medical image classification, COVID-19 diagnosis

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