Application of a null-beamformer to source localisation in MEG data of deep brain stimulation
Abstract
In this paper, we present an analysis of magnetoencephalography (MEG) signals from a patient with whole-body chronic pain in order to investigate changes in neural activity induced by DBS. The patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). Using MEG to reconstruct the neural activity of interest is challenging because of interference to the signal from the DBS device. We demonstrate that a null-beamformer can be used to localise neural activity despite artefacts caused by the presence of DBS electrodes and stimulus pulses. We subsequently verified the accuracy of our source localisation by correlating the predicted DBS electrode positions with their actual positions, previously identified using anatomical imaging. We also demonstrated increased activity in pain-related regions including the pre-supplementary motor area, brainstem periaqueductal gray and medial prefrontal areas when the patient was in pain compared to when the patient experienced pain relief.
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DBS of the anterior cingulate cortex in chronic pain produced stimulation-specific relief of symptoms accompanied by diffuse functional connectivity changes in the pre-supplementary motor area, brainstem periaqueductal gray matter, rostral anterior cingulate, and medial prefrontal areas.
“DBS of the anterior cingulate cortex in chronic pain produced stimulation-specific relief of symptoms that was accompanied by diffuse functional connectivity changes in the pre-supplementary motor area, brainstem periaqueductal gray matter, rostral anterior cingulate, and medial prefrontal areas.70”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [70]
Stimulating the anterior cingulate cortex can be an effective DBS target for a range of conditions, including depression and OCD.
“which can be an effective DBS target for a range of conditions, including depression and obsessivecompulsive disorder.”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [70]
Cites
Deep brain stimulation for chronic pain investigated with magnetoencephalography
Kringelbach, M. L., Jenkinson, N., Green, A. L., Owen, S. L. F., Hansen, P. C., Cornelissen, P. L., Holliday, I. E., Stein, J., & Aziz, T. Z. (2007) · NeuroReport · doi:10.1097/wnr.0b013e328010dc3d · Cited by 101 · see citing works
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Hart, M. G., Ypma, R. J. F., Romero-Garcia, R., Price, S. J., & Suckling, J. (2016) · Journal of Neurosurgery · doi:10.3171/2015.4.jns142683 · Cited by 74 · see citing works
Balancing the Brain: Resting State Networks and Deep Brain Stimulation
Kringelbach, M. L., Green, A. L., & Aziz, T. Z. (2011) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2011.00008 · Cited by 72 · see citing works
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- Authors
- Mohseni, H. R., Kringelbach, M. L., Smith, P. P., Green, A. L., Parsons, C. E., Young, K. S., Brittain, J.-S., Hyam, J. A., Schweder, P. M., Stein, J. F., & Aziz, T. Z.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- ORCID
- Venue
- 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
- Publisher
- IEEE
- Published
- 2010-08
- Volume
- 2010
- Pages
- 4120-4123
- ISSN
- 2375-7477 (ISSN-L)
- OpenAlex
- W2080920443
- Cited by
- 22
- References
- 1
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 4 · 2018: 1 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 23.74
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (WT 088877/Z/09/Z)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Physical Sciences › Computer Science › Signal Processing › Direction-of-Arrival Estimation Techniques
- Keywords
- source localization, magnetoencephalography, deep brain stimulation, anterior cingulate cortex, chronic pain, pre-supplementary motor area, periaqueductal gray, medial prefrontal cortex, analgesia
- MeSH terms
- Electrodes, Humans, Male, Middle Aged, Magnetoencephalography, Deep Brain Stimulation
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