Balancing the Brain: Resting State Networks and Deep Brain Stimulation
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Over the last three decades, large numbers of patients with otherwise treatment-resistant disorders have been helped by deep brain stimulation (DBS), yet a full scientific understanding of the underlying neural mechanisms is still missing. We have previously proposed that efficacious DBS works by restoring the balance of the brain's resting state networks. Here, we extend this proposal by reviewing how detailed investigations of the highly coherent functional and structural brain networks in health and disease (such as Parkinson's) have the potential not only to increase our understanding of fundamental brain function but of how best to modulate the balance. In particular, some of the newly identified hubs and connectors within and between resting state networks could become important new targets for DBS, including potentially in neuropsychiatric disorders. At the same time, it is of essence to consider the ethical implications of this perspective.
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DBS has been used for psychiatric conditions, but its mechanism of action is poorly understood, and the effects are capricious.
“Deep brain stimulation (DBS) has been used for psychiatric conditions, but its mechanism of action is poorly understood, and the effects are capricious.58”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [58]
The ‘Balancing Resting State Networks in Disease’ section says DBS is an emerging treatment for neuropsychiatric disorders and that its mechanisms there are less well mapped than in Parkinson’s disease. It also describes reversible induction of severe depression during DBS for Parkinson’s disease, but does not establish that DBS effects are generally capricious. The indexed passages provide section labels but no page numbers. (LLM, conf=0.85)
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- Authors
- Kringelbach, M. L., Green, A. L., & Aziz, T. Z.
- Affiliations
- Aarhus University (DK)
- University of Oxford (GB)
- Corresponding author
- Kringelbach, Morten L.
- Venue
- Frontiers in Integrative Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2011
- Volume
- 5
- Pages
- 8-8
- ISSN
- 1662-5145 (ISSN-L)
- PMC
- PMC3088866
- OpenAlex
- W1974098862
- Cited by
- 72
- References
- 66
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 14 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Integrative Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Scopus (Elsevier) (submittedVersion)
- Funders
- Fondation pour la Recherche Médicale
- TrygFonden
- Norman Collisson Foundation
- Medical Research Council
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- deep brain stimulation, resting-state networks, brain network hubs, Parkinson's disease, neuropsychiatric disorders, treatment-resistant disorders
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