Deep brain stimulation for chronic pain investigated with magnetoencephalography
Open accessAbstract
Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain.
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When the stimulator was turned off, worsening symptoms were associated with reduced activity in the same areas.
“when the stimulator was turned off, worsening symptoms were associated with reduced activity in the same areas”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [59]
During DBS of PVG/PAG for chronic phantom limb pain, subjective symptom relief was correlated with significantly increased activity in the left midanterior orbitofrontal cortex and right subgenual cingulate cortex.
“During stimulation, subjective symptom relief was correlated with significantly increased activity in the left midanterior orbitofrontal cortex and right subgenual cingulate cortex”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [59]
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- Authors
- Kringelbach, M. L., Jenkinson, N., Green, A. L., Owen, S. L. F., Hansen, P. C., Cornelissen, P. L., Holliday, I. E., Stein, J., & Aziz, T. Z.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Newcastle University (GB)
- Aston University (GB)
- Corresponding author
- Kringelbach, Morten L.
- Aziz, Tipu Z.
- ORCID
- Venue
- NeuroReport
- Published
- 2007-02-12
- Volume
- 18
- Issue
- 3
- Pages
- 223-228
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1964099314
- Cited by
- 101
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 10 · 2014: 6 · 2013: 6 · 2012: 10
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, chronic pain, phantom limb pain, magnetoencephalography, orbitofrontal cortex, subgenual anterior cingulate cortex, treatment-resistant pain, surgical targets
- MeSH terms
- Brain, Brain Mapping, Chronic Disease, Gyrus Cinguli, Humans, Functional Laterality, Male, Middle Aged, Nerve Net, Pain, Intractable, Intractable Pain, Phantom Limb, Predictive Value of Tests, Magnetoencephalography, Treatment Outcome, Prefrontal Cortex, Deep Brain Stimulation
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