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A method for normalizing histology slides for quantitative analysis

Macenko, Marc, Niethammer, Marc, Marron, J. S., Borland, David, Woosley, John T., Xiaojun Guan, Schmitt, Charles, Thomas, Nancy E.·2009·2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro

DOI 10.1109/isbi.2009.5193250

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Abstract

Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to enable improved quantitative analysis.

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Authors: Macenko, M., Niethammer, M., Marron, J. S., Borland, D., Woosley, J. T., Guan, X., Schmitt, C., & Thomas, N. E.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Niethammer, Marc
Marron, J. S.
Borland, David
Woosley, John T.
Xiaojun Guan
Schmitt, Charles
Thomas, Nancy E.
Venue: 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Publisher: IEEE
Published: 2009-06
Pages: 1107-1110
DOI: 10.1109/isbi.2009.5193250
OpenAlex: W2132162500
Cited by: 1,482
References: 10
Citations by year: 2026: 170 · 2025: 198 · 2024: 208 · 2023: 182 · 2022: 190 · 2021: 149 · 2020: 114 · 2019: 91 · 2018: 57 · 2017: 41 · 2016: 28 · 2015: 21 · 2014: 14 · 2013: 6 · 2012: 5
FWCI: 2.81
Type: conference paper
Language: en
Open access: closed
Locations: IEEE International Symposium on Biomedical Imaging (ISBI) (publishedVersion)
Topics: Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Digital Imaging for Blood Diseases
Keywords: quantitative histology, image normalization, histological image analysis

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A method for normalizing histology slides for quantitative analysis

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