The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ultrashort electrical pulses open a new gateway into biological cells
Abstract
An electrical model for biological cells predicts that for pulses with durations shorter than the charging time of the outer membrane, there is an increasing probability of electric field interactions with intracellular structures. Experimental studies in which human cells were exposed to pulsed electric fields of up to 300-kV/cm amplitude, with durations as short as 10 ns, have confirmed this hypothesis. The observed effects include the breaching of intracellular granule membranes without permanent damage to the cell membrane, abrupt rises in intracellular free calcium levels, and enhanced expression of genes. At increased electric fields, the application of submicrosecond pulses induces apoptosis (programmed cell death) in biological cells, an effect that has been shown to reduce the growth of tumors. Possible applications of the intracellular electroeffect are enhancing gene delivery to the nucleus, controlling cell functions that depend on calcium release (causing cell immobilization), and treating tumors.
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Cites
The permeability transition pore complex: another view
Halestrap, A. P., McStay, G. P., & Clarke, S. J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01375-5 · Cited by 709
An approach to electrical modeling of single and multiple cells
Gowrishankar, T. R., & Weaver, J. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0636434100 · Cited by 204
Cited by
Nanosecond pulsed electric fields cause melanomas to self-destruct
Nuccitelli, R., Pliquett, U., Chen, X., Ford, W., James Swanson, R., Beebe, S. J., Kolb, J. F., & Schoenbach, K. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.181 · Cited by 512
Self-citationPerspectives on external electric fields in molecular simulation: progress, prospects and challenges
English, N. J., & Waldron, C. J. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp00629e · Cited by 273
Zhang, Q., Zhuang, J., von Woedtke, T., Kolb, J. F., Zhang, J., Fang, J., & Weltmann, K.-D. (2014) · Applied Physics Letters · doi:10.1063/1.4895731 · Cited by 73
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Metadata
- Authors
- Schoenbach, K. H., Joshi, R. P., Kolb, J. F., Chen, N., Stacey, M., Blackmore, P. F., Buescher, E. S., & Beebe, S. J.
- Venue
- Proceedings of the IEEE
- Published
- 2004-07
- Volume
- 92
- Issue
- 7
- Pages
- 1122-1137
- ISSN
- 0018-9219 (ISSN-L)
- 1558-2256
- OpenAlex
- W1972708469
- Cited by
- 404
- References
- 2
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schoenbach, K. H., Joshi, R. P., Kolb, J. F., Chen, N., Stacey, M., Blackmore, P. F., Buescher, E. S., & Beebe, S. J. (2004). Ultrashort electrical pulses open a new gateway into biological cells. Proceedings of the IEEE. https://doi.org/10.1109/jproc.2004.829009
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