An implantable multielectrode array with on-chip signal processing
Abstract
This active probe can be used for the long-term recording of extracellular neural biopotentials and as a basis for closed-loop neural prostheses. The probe incorporates on-chip circuitry for amplifying, multiplexing, and buffering neural signals recorded from ten recording electrodes spaced 100-/spl mu/m apart. It requires only three leads and operates from a single 5-V supply. On-chip self-test circuitry for testing electrode impedance levels is provided. The on-chip circuitry is fabricated in a die area of 1.3 mm/SUP 2/ using 6-/spl mu/m LOCOS enhancement-depletion NMOS technology, and dissipates 5 mW of power. The probe is 4.7 mm long and 15 /spl mu/m thick, and has a shank which tapers from 160 /spl mu/m near the base to less than 15 /spl mu/m near the tip.
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Silicon-based microdevices have the advantage of monolithic integration of electronic circuits for recording and signal processing.
“One advantage of siliconbased microdevices is the ability of monolithic integration of electronic circuits for recording and signal processing (Najafi and Wise, 1986; Ji et al., 1990)”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Najafi and Wise, 1986
The most common front-end amplifier for IC neural recordings was first proposed by Najafi and Wise and later refined by Harrison to its present circuit.
“The most common front-end amplifier for IC neural recordings was first proposed by Najafi and Wise [89] and then further refined by Harrison [52] to its present circuit shown in Fig. 4.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [89]
CNS-based neuroprostheses, or brain-machine interfaces, decode neural electrical activity to control robotic limbs or to stimulate muscles for restoring limb function.
“CNS-based neuroprostheses, or brain–machine interfaces (BMIs), are systems whereby neural electrical activities are decoded and used to control robotic limbs [76, 89, 105] or to stimulate muscles for restoring limb function [35].”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [89]
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References 14 · Cited by 310
- Authors
- Najafi, K., & Wise, K. D.
- Affiliations
- University of Michigan (US)
- Venue
- IEEE Journal of Solid-State Circuits
- Published
- 1986-12
- Volume
- 21
- Issue
- 6
- Pages
- 1035-1044
- ISSN
- 0018-9200 (ISSN-L)
- OpenAlex
- W2164072701
- Cited by
- 310
- References
- 14
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 13 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Journal of Solid-State Circuits (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › CCD and CMOS Imaging Sensors
- Keywords
- implantable neural probes, microelectrode arrays, on-chip signal processing, extracellular neural recording, signal amplification, signal multiplexing, low-power CMOS circuit, NMOS technology
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