Novel computational linguistic measures, dialogue system and the development of SOPHIE: standardized online patient for healthcare interaction education
Open accessAbstract
In this article, we describe the iterative participatory design of SOPHIE, an online virtual patient for feedback-based practice of sensitive patient-physician conversations, and discuss an initial qualitative evaluation of the system by professional end users. The design of SOPHIE was motivated from a computational linguistic analysis of the transcripts of 383 patient-physician conversations from an essential office visit of late stage cancer patients with their oncologists. We developed methods for the automatic detection of two behavioral paradigms, lecturing and positive language usage patterns (sentiment trajectory of conversation), that are shown to be significantly associated with patient prognosis understanding. These automated metrics associated with effective communication were incorporated into SOPHIE, and a pilot user study identified that SOPHIE was favorably reviewed by a user group of practicing physicians.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Digital clinical empathy requires intentional strategies (timely acknowledgment, authenticity, appropriate boundary setting, contextual responsiveness) and may be best sustained through hybrid models combining AI-enabled support with human oversight.
“Studies measuring cancer-related live chat environments and simulation-based systems highlight that digital clinical empathy requires intentional strategies (ie, timely acknowledgment, authenticity, appropriate boundary setting, and contextual responsiveness) and may be best sustained through hybrid models that combine AI-enabled support with human oversight [34-36].”
From Empathic AI for Patient-Centered Cancer Care: A Scoping Review of Patient Navigation, Support, and Clinical Practice (2026) · cites this paper as [36]
Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
VADER: a parsimonious rule-based model for sentiment analysis of social media text
Hutto, C., & Gilbert, E. (2014) · Proceedings of the International AAAI Conference on Web and Social Media · doi:10.1609/icwsm.v8i1.14550 · Cited by 6,087 · see citing works
McGreevey, J. D., Hanson, C. W., & Koppel, R. (2020) · JAMA · doi:10.1001/jama.2020.2724 · Cited by 112 · see citing works
Flagged first, then by citations
Research works printed but not linked: 45
- [2][2] Mohammad Rafayet Ali, Taylan Sen, Dev Crasta, Viet-Duy Nguyen, Ronald Rogge, and Mohammed Ehsan Hoque. 2018. The what, when, and why of facial expressions: An objective analysis of conversational skills in speed-dating videos. In 2018 13th IEEE International Conference on Automatic Face & Gesture Recognition (FG 2018) . IEEE, 203-209. -
- [3][3] Daniel Angus, Bernadette Watson, Andrew Smith, Cindy Gallois, and Janet Wiles. 2012. Visualising conversation structure across time: Insights into effective doctor-patient consultations. PloS one 7, 6 (2012). -
- [4][4] Anthony L Back, Robert M Arnold, Walter F Baile, James A Tulsky, and Kelly Fryer-Edwards. 2005. Approaching difficult communication tasks in oncology 1. CA: a cancer journal for clinicians 55, 3 (2005), 164-177. -
- [5][5] Walter F Baile, Robert Buckman, Renato Lenzi, Gary Glober, Estela A Beale, and Andrzej P Kudelka. 2000. SPIKESâĂŤa six-step protocol for delivering bad news: application to the patient with cancer. The oncologist 5, 4 (2000), 302-311. -
- [6][6] Rainer S Beck, Rebecca Daughtridge, and Philip D Sloane. 2002. Physician-patient communication in the primary care office: a systematic review. The Journal of the American Board of Family Practice 15, 1 (2002), 25-38. -
- [7][7] William F Bond, Teresa J Lynch, Matthew J Mischler, Jessica L Fish, Jeremy S McGarvey, Jason T Taylor, Dipen M Kumar, Kyle M Mou, Rebecca A Ebert-Allen, Dilip N Mahale, et al. 2019. Virtual Standardized Patient Simulation: Case Development and Pilot Application to High-Value Care. Simulation in Healthcare 14, 4 (2019), 241-250. -
- [8][8] Norman Cliff. 1993. Dominance statistics: Ordinal analyses to answer ordinal questions. Psychological bulletin 114, 3 (1993), 494. -
- [9][9] David DeVault, Ron Artstein, Grace Benn, Teresa Dey, Ed Fast, Alesia Gainer, Kallirroi Georgila, Jon Gratch, Arno Hartholt, Margaux Lhommet, et al. 2014. SimSensei Kiosk: A virtual human interviewer for healthcare decision support. In Proceedings of the 2014 international conference on Autonomous agents and multi-agent systems . International Foundation for Autonomous Agents and Multiagent Systems, 1061-1068. -
- [10][10] Zelda Di Blasi, Elaine Harkness, Edzard Ernst, Amanda Georgiou, and Jos Kleijnen. 2001. Influence of context effects on health outcomes: a systematic review. The Lancet 357, 9258 (2001), 757-762. -
- [11][11] Cezanne M Elias, Cleveland G Shields, Jennifer J Griggs, Kevin Fiscella, Sharon L Christ, Joseph Colbert, Stephen G Henry, Beth G Hoh, Haslyn ER Hunte, Mary Marshall, et al. 2017. The social and behavioral influences (SBI) study: study design and rationale for studying the effects of race and activation on cancer pain management. BMC cancer 17, 1 (2017), 575. -
- [12][12] Ronald M Epstein, Paul R Duberstein, Joshua J Fenton, Kevin Fiscella, Michael Hoerger, Daniel J Tancredi, Guibo Xing, Robert Gramling, Supriya Mohile, Peter Franks, et al. 2017. Effect of a patient-centered communication intervention on oncologist-patient communication, quality of life, and health care utilization in advanced cancer: the VOICE randomized clinical trial. JAMA oncology 3, 1 (2017), 92-100. -
- [13][13] Linda A Fogarty, Barbara A Curbow, John R Wingard, Karen McDonnell, and Mark R Somerfield. 1999. Can 40 seconds of compassion reduce patient anxiety? Journal of Clinical Oncology 17, 1 (1999), 371-371. -
- [14][14] Robert Gramling, Kevin Fiscella, Guibo Xing, Michael Hoerger, Paul Duberstein, Sandy Plumb, Supriya Mohile, Joshua J Fenton, Daniel J Tancredi, Richard L Kravitz, et al. 2016. Determinants of patient-oncologist prognostic discordance in advanced cancer. JAMA oncology 2, 11 (2016), 1421-1426. -
- [15][15] Liz Gwyther and Fiona Rawlinson. 2007. Palliative medicine teaching program at the University of Cape Town: Integrating palliative care principles into practice. Journal of pain and symptom management 33, 5 (2007), 558-562. -
- [16][16] Jennifer Hill, W Randolph Ford, and Ingrid G Farreras. 2015. Real conversations with artificial intelligence: A comparison between human-human online conversations and human-chatbot conversations. Computers in human behavior 49 (2015), 245-250. -
- [17][17] Michael Hoerger, Ronald M Epstein, Paul C Winters, Kevin Fiscella, Paul R Duberstein, Robert Gramling, Phyllis N Butow, Supriya G Mohile, Paul R Kaesberg, Wan Tang, et al. 2013. Values and options in cancer care (VOICE): study design and rationale for a patientcentered communication and decision-making intervention for physicians, patients with advanced cancer, and their caregivers. BMC cancer 13, 1 (2013), 188. -
- [19][19] Emmanuel S Kamonyo. 2018. The palliative care journey in Kenya and Uganda. Journal of pain and symptom management 55, 2 (2018), S46-S54. -
- [21][21] Bennett Kleinberg, Maximilian Mozes, and Isabelle van der Vegt. 2018. Identifying the sentiment styles of YouTube's vloggers. CoRR abs/1808.09722 (2018). arXiv:1808.09722 http://arxiv.org/abs/1808.09722 - · arXiv
- [22][22] Andrea Kleinsmith, Diego Rivera-Gutierrez, Glen Finney, Juan Cendan, and Benjamin Lok. 2015. Understanding empathy training with virtual patients. Computers in human behavior 52 (2015), 151-158. -
- [23][23] Chunfeng Liu, Karen M Scott, Renee L Lim, Silas Taylor, and Rafael A Calvo. 2016. EQClinic: a platform for learning communication skills in clinical consultations. Medical education online 21, 1 (2016), 31801. -
- [24][24] Stuart Lloyd. 1982. Least squares quantization in PCM. IEEE transactions on information theory 28, 2 (1982), 129-137. -
- [25][25] Pam Malloy, Juli Boit, Allison Tarus, Joyce Marete, Betty Ferrell, and Zipporah Ali. 2017. Providing palliative care to patients with cancer: Addressing the needs in Kenya. Asia-Pacific journal of oncology nursing 4, 1 (2017), 45. -
- [26][26] Lynda Millard, Christine Hallett, and Karen Luker. 2006. Nurse-patient interaction and decision-making in care: patient involvement in community nursing. Journal of Advanced Nursing 55, 2 (2006), 142-150. -
- [28][28] Julian Oates, W Wayne Weston, and John Jordan. 2000. The impact of patient-centered care on outcomes. Fam Pract 49, 9 (2000), 796-804. -
- [29][29] Emanuel Parzen. 1962. On estimation of a probability density function and mode. The annals of mathematical statistics 33, 3 (1962), 1065-1076. -
- [30][30] Monica Peddle, Lisa Mckenna, Margaret Bearman, and Debra Nestel. 2019. Development of non-technical skills through virtual patients for undergraduate nursing students: an exploratory study. Nurse education today 73 (2019), 94-101. -
- [31][31] Seyedeh Zahra Razavi, Mohammad Rafayet Ali, Tristram H Smith, Lenhart K Schubert, and Mohammed Ehsan Hoque. 2016. The LISSA virtual human and ASD teens: An overview of initial experiments. In International Conference on Intelligent Virtual Agents . Springer, 460-463. -
- [34][34] Andrew J Reagan, Lewis Mitchell, Dilan Kiley, Christopher M Danforth, and Peter Sheridan Dodds. 2016. The emotional arcs of stories are dominated by six basic shapes. EPJ Data Science 5, 1 (2016), 31. -
- [35][35] Rachel A Rodenbach, Kim Brandes, Kevin Fiscella, Richard L Kravitz, Phyllis N Butow, Adam Walczak, Paul R Duberstein, Peter Sullivan, Beth Hoh, Guibo Xing, et al. 2017. Promoting end-of-life discussions in advanced cancer: effects of patient coaching and question prompt lists. Journal of Clinical Oncology 35, 8 (2017), 842. -
- [36][36] Peter J Rousseeuw. 1987. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. Journal of computational and applied mathematics 20 (1987), 53-65. -
- [37][37] Gideon Schwarz et al. 1978. Estimating the dimension of a model. The annals of statistics 6, 2 (1978), 461-464. -
- [38][38] Taylan Sen, Mohammad Rafayet Ali, Mohammed Ehsan Hoque, Ronald Epstein, and Paul Duberstein. 2017. Modeling doctor-patient communication with affective text analysis. In 2017 Seventh International Conference on Affective Computing and Intelligent Interaction (ACII) . IEEE, 170-177. -
- [39][39] Claude Elwood Shannon. 2001. A mathematical theory of communication. ACM SIGMOBILE mobile computing and communications review 5, 1 (2001), 3-55. -
- [40][40] Daniel E Shapiro, Stephen R Boggs, Barbara G Melamed, and John Graham-Pole. 1992. The effect of varied physician affect on recall, anxiety, and perceptions in women at risk for breast cancer: an analogue study. Health Psychology 11, 1 (1992), 61. -
- [41][41] Cleveland G Shields, Jennifer J Griggs, Kevin Fiscella, Cezanne M Elias, Sharon L Christ, Joseph Colbert, Stephen G Henry, Beth G Hoh, Haslyn ER Hunte, Mary Marshall, et al. 2019. The Influence of Patient Race and Activation on Pain Management in Advanced Lung Cancer: a Randomized Field Experiment. Journal of general internal medicine 34, 3 (2019), 435-442. -
- [42][42] Laura A Siminoff, Peter Ravdin, Natalie Colabianchi, and Christina M Saunders Sturm. 2000. Doctor-patient communication patterns in breast cancer adjuvant therapy discussions. Health expectations 3, 1 (2000), 26-36. -
- [43][43] Mark Stoltenberg, Dingle Spence, Bethany-Rose Daubman, Natalie Greaves, Rebecca Edwards, Brittany Bromfield, Pedro E Perez-Cruz, Eric L Krakauer, M Austin Argentieri, and Alexandra E Shields. 2020. The central role of provider training in implementing resourcestratified guidelines for palliative care in low-income and middle-income countries: Lessons from the Jamaica Cancer Care and Research Institute in the Caribbean and Universidad Católica in Latin America. Cancer 126 (2020), 2448-2457. -
- [44][44] Alexandre Trilla and Francesc Alias. 2012. Sentence-based sentiment analysis for expressive text-to-speech. IEEE transactions on audio, speech, and language processing 21, 2 (2012), 223-233. -
- [45][45] Shaghayegh Vahdat, Leila Hamzehgardeshi, Somayeh Hessam, and Zeinab Hamzehgardeshi. 2014. Patient involvement in health care decision making: a review. Iranian Red Crescent Medical Journal 16, 1 (2014). -
- [46][46] Willemijn Y van der Plas, Stan Benjamens, and Schelto Kruijff. 2020. The increased need for palliative cancer care in Sub-Saharan Africa. European Journal of Surgical Oncology (2020). -
- [47][47] Mara van Osch, Milou Sep, Liesbeth M van Vliet, Sandra van Dulmen, and Jozien M Bensing. 2014. Reducing patientsâĂŹ anxiety and uncertainty, and improving recall in bad news consultations. Health Psychology 33, 11 (2014), 1382. -
- [48][48] Kurt Vonnegut. 1999. Palm Sunday: an autobiographical collage . Dial Press. -
- [49][49] Jane C Weeks, Paul J Catalano, Angel Cronin, Matthew D Finkelman, Jennifer W Mack, Nancy L Keating, and Deborah Schrag. 2012. Patients' expectations about effects of chemotherapy for advanced cancer. New England Journal of Medicine 367, 17 (2012), 1616-1625. Proc. ACM Meas. Anal. Comput. Syst., Vol. 37, No. 4, Article 111. Publication date: August 2018. Novel Computational Linguistic Measures, Dialogue System and the Development of SOPHIE: Standardized Online Patient for Healthcare Interaction Education · 111:21 -
- [50][50] Jane C Weeks, E Francis Cook, Steven J O'day, Lynn M Peterson, Neil Wenger, Douglas Reding, Frank E Harrell, Peter Kussin, Neil V Dawson, Alfred F Connors Jr, et al. 1998. Relationship between cancer patients' predictions of prognosis and their treatment preferences. Jama 279, 21 (1998), 1709-1714. -
- [51][51] Nabil Zary, Gunilla Johnson, Jonas Boberg, and Uno GH Fors. 2006. Development, implementation and pilot evaluation of a Web-based Virtual Patient Case Simulation environment-Web-SP. BMC medical education 6, 1 (2006), 10.
Cited by
Sorted by citations
Facing epistemic and complex uncertainty in serious illness: The role of mindfulness and shared mind
Epstein, R. M. (2021) · Patient Education and Counseling · doi:10.1016/j.pec.2021.07.030 · Cited by 31 · see citing works
Self-citationWhite, B. M., Aitken, G. L., Zink, J. A., Kheirkhah Rahimabad, P., Kumsa, F. A., Hashtarkhani, S., Rashid, R., Kheirinejad, S., Girdwood, T., Brett, C. L., et al. (2026) · JMIR Cancer · doi:10.2196/82336 · Cited by 2 · see citing works
“…systems highlight that digital clinical empathy requires intentional strategies (ie, timely acknowledgment, authenticity, appropriate boundary setting, and contextual responsiveness) and may be best sustained through hybrid models that combine AI-enabled support with human oversight [34-36].”
- Authors
- Ali, M. R., Sen, T., Kane, B., Bose, S., Carroll, T. M., Epstein, R., Schubert, L., & Hoque, E.
- Affiliations
- University of Rochester (US)
- University of Rochester Medicine (US)
- Department of Computer Science, University of Rochester, Rochester, NY, USA
- ORCID
- Venue
- IEEE Transactions on Affective Computing
- Published
- 2023-01-01
- Volume
- 14
- Issue
- 1
- Pages
- 223-235
- ISSN
- 1949-3045 (ISSN-L)
- 2371-9850
- OpenAlex
- W3088208299
- Cited by
- 40
- References
- 2
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 17 · 2021: 1
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Licence
- Locations
- IEEE Transactions on Affective Computing (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Science Foundation (#1449828)
- Defense Advanced Research Projects Agency (W911NF-19-1-0029)
- Army Research Office
- Topics
- Health Sciences › Health Professions › General Health Professions › Patient-Provider Communication in Healthcare
- Physical Sciences › Computer Science › Artificial Intelligence › Speech and dialogue systems
- Social Sciences › Psychology › Social Psychology › Social Robot Interaction and HRI
- Keywords
- Sophie, virtual patients, patient-physician communication, late-stage cancer, computational linguistics, sentiment analysis, positive language, prognosis understanding, dialogue systems, participatory design, physician training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review