A Programmable Implantable Microstimulator SoC With Wireless Telemetry: Application in Closed-Loop Endocardial Stimulation for Cardiac Pacemaker
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A low-power, wireless, and implantable microstimulator system on chip with smart powering management, immediate neural signal acquisition, and wireless rechargeable system is proposed. A system controller with parity checking handles the adjustable stimulus parameters for the stimulated objective. In the current paper, the rat's intra-cardiac electrogram is employed as the stimulated model in the animal study, and it is sensed by a low-voltage and low-power monitoring analog front end. The power management unit, which includes a rectifier, battery charging and detection, and a regulator, is used for the power control of the internal circuits. The stimulation data and required clock are extracted by a phase-locked-loop-based phase shift keying demodulator from an inductive AC signal. The full chip, which consumes 48 μW only, is fabricated in a TSMC 0.35 μm 2P4M standard CMOS process to perform the monitoring and pacing functions with inductively powered communication in the in vivo study.
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Inductive power transfer introduces bioengineering challenges due to Specific Absorption Rate limits and minimal size capacity for device implantation.
“However, inductive power transfer introduces numerous bioengineering challenges due to Specific Absorption Rate (SAR) limits and minimal size capacity for device implantation.”
From Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system (2017) · cites this paper as [17]
Cites
A low-power low-noise cmos for amplifier neural recording applications
Harrison, R. R., & Charles, C. (2003) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2003.811979 · Cited by 1,695 · see citing works
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Powering implantable and ingestible electronics
Yang, S., Sencadas, V., You, S. S., Jia, N. Z., Srinivasan, S. S., Huang, H., Ahmed, A. E., Liang, J. Y., & Traverso, G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009289 · Cited by 183 · see citing works
A 0.7-V 17.4-/spl mu/W 3-Lead Wireless ECG SoC
Khayatzadeh, M., Zhang, X., Tan, J., Liew, W.-S., & Lian, Y. (2013) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2013.2279398 · Cited by 73 · see citing works
Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system
Abiri, P., Abiri, A., Packard, R. R. S., Ding, Y., Yousefi, A., Ma, J., Bersohn, M., Nguyen, K.-L., Markovic, D., Moloudi, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06493-5 · Cited by 67 · see citing works
- Authors
- Lee, S.-Y., Su, M. Y., Liang, M.-C., Chen, Y.-Y., Hsieh, C.-H., Yang, C.-M., Lai, H.-Y., Lin, J.-W., & Fang, Q.
- Affiliations
- National Chung Cheng University (TW)
- National Yang Ming University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- Melbourne Institute of Technology (AU)
- Venue
- IEEE Transactions on Biomedical Circuits and Systems
- Published
- 2011-12
- Volume
- 5
- Issue
- 6
- Pages
- 511-522
- ISSN
- 1932-4545 (ISSN-L)
- 1940-9990
- OpenAlex
- W2031790846
- Cited by
- 102
- References
- 1
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 15 · 2014: 3 · 2013: 13 · 2012: 5
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Locations
- IEEE Transactions on Biomedical Circuits and Systems (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- RMIT University
- Johnson and Johnson
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Biomedical Engineering › Wireless Body Area Networks
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- system-on-chip, cardiac pacemaker, wireless telemetry, inductive power transfer, wireless charging, power management, phase-locked loop demodulation, phase-shift keying, low-power analog front-end, parity check, rat model
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