Cited by 192Medical Imaging and AnalysisMedical Image Segmentation TechniquesAdvanced Neural Network Applications

Detecting Anatomical Landmarks From Limited Medical Imaging Data Using Two-Stage Task-Oriented Deep Neural Networks

Open access
Zhang, Jun, Liu, Mingxia, Shen, Dinggang·2017·IEEE Transactions on Image Processing

Abstract

One of the major challenges in anatomical landmark detection, based on deep neural networks, is the limited availability of medical imaging data for network learning. To address this problem, we present a two-stage task-oriented deep learning method to detect large-scale anatomical landmarks simultaneously in real time, using limited training data. Specifically, our method consists of two deep convolutional neural networks (CNN), with each focusing on one specific task. Specifically, to alleviate the problem of limited training data, in the first stage, we propose a CNN based regression model using millions of image patches as input, aiming to learn inherent associations between local image patches and target anatomical landmarks. To further model the correlations among image patches, in the second stage, we develop another CNN model, which includes a) a fully convolutional network that shares the same architecture and network weights as the CNN used in the first stage and also b) several extra layers to jointly predict coordinates of multiple anatomical landmarks. Importantly, our method can jointly detect large-scale (e.g., thousands of) landmarks in real time. We have conducted various experiments for detecting 1200 brain landmarks from the 3D T1-weighted magnetic resonance images of 700 subjects, and also 7 prostate landmarks from the 3D computed tomography images of 73 subjects. The experimental results show the effectiveness of our method regarding both accuracy and efficiency in the anatomical landmark detection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1109/tip.2017.2721106

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 41 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Zhang, J., Liu, M., & Shen, D.
Affiliations
University of North Carolina at Chapel Hill (US)
Venue
IEEE Transactions on Image Processing
Published
2017-10
Volume
26
Issue
10
Pages
4753-4764
ISSN
  • 1057-7149 (ISSN-L)
  • 1941-0042
OpenAlex
W2724710774
Cited by
192
References
41
Citations by year
2026: 10 · 2025: 14 · 2024: 11 · 2023: 16 · 2022: 31 · 2021: 29 · 2020: 29 · 2019: 20 · 2018: 26 · 2017: 6
FWCI
9.98
Type
journal article
Language
en
Open access
Locations
  • IEEE Transactions on Image Processing (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • UNC Libraries
Funders
NIH (EB006733, EB008374, EB009634, MH100217, AG041721, AG049371, AG042599)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
Keywords
anatomical landmark detection, limited training data, convolutional neural networks, fully convolutional network, 3D medical images, T1-weighted imaging, CT images

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review