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Large deformation diffeomorphic metric mapping of vector fields

Open access
Yan Cao, Miller, M.I., Winslow, R.L., Younes, L.·2005·IEEE Transactions on Medical Imaging

Abstract

In large-deformation diffeomorphic metric mapping (LDDMM), the diffeomorphic matching of images are modeled as evolution in time, or a flow, of an associated smooth velocity vector field v controlling the evolution. The initial momentum parameterizes the whole geodesic and encodes the shape and form of the target image. Thus, methods such as principal component analysis (PCA) of the initial momentum leads to analysis of anatomical shape and form in target images without being restricted to small-deformation assumption in the analysis of linear displacements. We apply this approach to a study of dementia of the Alzheimer type (DAT). The left hippocampus in the DAT group shows significant shape abnormality while the right hippocampus shows similar pattern of abnormality. Further, PCA of the initial momentum leads to correct classification of 12 out of 18 DAT subjects and 22 out of 26 control subjects.

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Metadata

Authors
Cao, Y., Miller, M. I., Winslow, R. L., & Younes, L.
Venue
IEEE Transactions on Medical Imaging
Published
2005-09
Volume
24
Issue
9
Pages
1216-1230
ISSN
0278-0062 (ISSN-L)
OpenAlex
W2145138920
Cited by
180
References
9
FWCI
11.17
Type
journal article
Language
en
Open access
green

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Cao, Y., Miller, M. I., Winslow, R. L., & Younes, L. (2005). Large deformation diffeomorphic metric mapping of vector fields. IEEE Transactions on Medical Imaging. https://doi.org/10.1109/tmi.2005.853923

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