The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Multiple SVM-RFE for Gene Selection in Cancer Classification With Expression Data
Abstract
This paper proposes a new feature selection method that uses a backward elimination procedure similar to that implemented in support vector machine recursive feature elimination (SVM-RFE). Unlike the SVM-RFE method, at each step, the proposed approach computes the feature ranking score from a statistical analysis of weight vectors of multiple linear SVMs trained on subsamples of the original training data. We tested the proposed method on four gene expression datasets for cancer classification. The results show that the proposed feature selection method selects better gene subsets than the original SVM-RFE and improves the classification accuracy. A Gene Ontology-based similarity assessment indicates that the selected subsets are functionally diverse, further validating our gene selection method. This investigation also suggests that, for gene expression-based cancer classification, average test error from multiple partitions of training and test sets can be recommended as a reference of performance quality.
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Cites
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Cited by
Gromski, P. S., Muhamadali, H., Ellis, D. I., Xu, Y., Correa, E., Turner, M. L., & Goodacre, R. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.02.012 · Cited by 905
Feature selection and analysis on correlated gas sensor data with recursive feature elimination
Yan, K., & Zhang, D. (2015) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2015.02.025 · Cited by 516
Schütte, M., Risch, T., Abdavi-Azar, N., Boehnke, K., Schumacher, D., Keil, M., Yildiriman, R., Jandrasits, C., Borodina, T., Amstislavskiy, V., et al. (2017) · Nature Communications · doi:10.1038/ncomms14262 · Cited by 339
SVM-RFE With MRMR Filter for Gene Selection
Mundra, P. A., & Rajapakse, J. C. (2010) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2009.2035284 · Cited by 332
Self-citationFeature selection methods for big data bioinformatics: A survey from the search perspective
Wang, L., Wang, Y., & Chang, Q. (2016) · Methods · doi:10.1016/j.ymeth.2016.08.014 · Cited by 331
Metadata
- Authors
- Duan, K.-B., Rajapakse, J. C., Wang, H., & Azuaje, F.
- Venue
- IEEE Transactions on Nanobioscience
- Published
- 2005-09
- Volume
- 4
- Issue
- 3
- Pages
- 228-234
- ISSN
- 1536-1241 (ISSN-L)
- OpenAlex
- W2103291381
- Cited by
- 468
- References
- 20
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
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