The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Functional ultrasound imaging of the brain: theory and basic principles
Abstract
Hemodynamic changes in the brain are often used as surrogates of neuronal activity to infer the loci of brain activity. A major limitation of conventional Doppler ultrasound for the imaging of these changes is that it is not sensitive enough to detect the blood flow in small vessels where the major part of the hemodynamic response occurs. Here, we present a μDoppler ultrasound method able to detect and map the cerebral blood volume (CBV) over the entire brain with an important increase in sensitivity. This method is based on imaging the brain at an ultrafast frame rate (1 kHz) using compounded plane wave emissions. A theoretical model demonstrates that the gain in sensitivity of the μDoppler method is due to the combination of 1) the high signal-to-noise ratio of the gray scale images, resulting from the synthetic compounding of backscattered echoes; and 2) the extensive signal averaging enabled by the high temporal sampling of ultrafast frame rates. This μDoppler imaging is performed in vivo on trepanned rats without the use of contrast agents. The resulting images reveal detailed maps of the rat brain vascularization with an acquisition time as short as 320 ms per slice. This new method is the basis for a real-time functional ultrasound (fUS) imaging of the brain.
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Cites
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What we can do and what we cannot do with fMRI
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Chronic optical access through a polished and reinforced thinned skull
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Cited by
Demene, C., Deffieux, T., Pernot, M., Osmanski, B.-F., Biran, V., Gennisson, J.-L., Sieu, L.-A., Bergel, A., Franqui, S., Correas, J.-M., et al. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2428634 · Cited by 983
Self-citationA gut-derived metabolite alters brain activity and anxiety behaviour in mice
Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature · doi:10.1038/s41586-022-04396-8 · Cited by 489
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Self-citationUltrasound Small Vessel Imaging With Block-Wise Adaptive Local Clutter Filtering
Song, P., Manduca, A., Trzasko, J. D., & Chen, S. (2017) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2016.2605819 · Cited by 258
Functional ultrasound imaging of brain activity in human newborns
Demene, C., Baranger, J., Bernal, M., Delanoe, C., Auvin, S., Biran, V., Alison, M., Mairesse, J., Harribaud, E., Pernot, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah6756 · Cited by 207
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Metadata
- Authors
- Mace, E., Montaldo, G., Osmanski, B.-F., Cohen, I., Fink, M., & Tanter, M.
- Venue
- IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
- Published
- 2013-03
- Volume
- 60
- Issue
- 3
- Pages
- 492-506
- ISSN
- 0885-3010 (ISSN-L)
- OpenAlex
- W2111291288
- Cited by
- 327
- References
- 6
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
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