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Average protein density is a molecular‐weight‐dependent function
Open accessAbstract
The mass density of proteins is a relevant basic biophysical quantity. It is also a useful input parameter, for example, for three‐dimensional structure determination by protein crystallography and studies of protein oligomers in solution by analytic ultracentrifugation. We have performed a critical analysis of published, theoretical, and experimental investigations about this issue and concluded that the average density of proteins is not a constant as often assumed. For proteins with a molecular weight below 20 kDa, the average density exhibits a positive deviation that increases for decreasing molecular weight. A simple molecular‐weight‐depending function is proposed that provides a more accurate estimate of the average protein density.
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Research works printed but not linked: 16
- 10.1107/S0907444995008754 · DOI
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Cited by
Luo, W., & Hong, M. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9096219 · Cited by 90
Santamaria, F., Gonzalez, J., Augustine, G. J., & Raghavachari, S. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000780 · Cited by 53
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Integrative characterization of the near‐minimal bacterium Mesoplasma florum
Matteau, D., Lachance, J., Grenier, F., Gauthier, S., Daubenspeck, J. M., Dybvig, K., Garneau, D., Knight, T. F., Jacques, P., & Rodrigue, S. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209844 · Cited by 16
“…According to typical ranges found in bacteria, the dry mass fraction ( DF ) and the dry mass specific density ( D DM ) were estimated to be between 20 – 30% and 1.3 – 1.5 g/ml, respectively (Bakken & Olsen, 1983; Bratbak & Dundas, 1984; Bratbak, 1985; Fischer et al , 2009; Bionumbers, 2015).”
InfluentialSingappuli-Arachchige, D., Feng, S., Wang, L., Palo, P. E., Shobade, S. O., Thomas, M., & Nilsen-Hamilton, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810305 · Cited by 8
Metadata
- Authors
- Fischer, H., Polikarpov, I., & Craievich, A. F.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 2004-10
- Volume
- 13
- Issue
- 10
- Pages
- 2825-2828
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2114225171
- Cited by
- 697
- References
- 0
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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