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Observation of sequence specificity in the seeding of protein amyloid fibrils
Open accessAbstract
It is well established that the rate of formation of fibrils by amyloidogenic proteins is enhanced by the addition of preformed fibrils, a phenomenon known as seeding. We show that the efficiency of seeding fibril formation from solutions of hen lysozyme by a series of other proteins depends strongly on the similarity of their sequences. This observation is consistent with the importance of long‐range interactions in stabilizing the core structure of amyloid fibrils and may be associated with the existence of a species barrier observed in the transmissible spongiform encephalopathies. In addition, it is consistent with the observation of a single dominant type of protein in the deposits associated with each form of amyloid disease.
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Cites
Protein folding and misfolding
Dobson, C. M. (2003) · Nature · doi:10.1038/nature02261 · Cited by 4,791
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Perutz, M. F., & Windle, A. H. (2001) · Nature · doi:10.1038/35084141 · Cited by 199
Cited by
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Gade Malmos, K., Blancas-Mejia, L. M., Weber, B., Buchner, J., Ramirez-Alvarado, M., Naiki, H., & Otzen, D. (2017) · Amyloid · doi:10.1080/13506129.2017.1304905 · Cited by 445
Jan, A., Gokce, O., Luthi-Carter, R., & Lashuel, H. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803159200 · Cited by 291
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Metadata
- Authors
- Krebs, M. R. H., Morozova‐Roche, L. A., Daniel, K., Robinson, C. V., & Dobson, C. M.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 13
- Issue
- 7
- Pages
- 1933-1938
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2104849621
- Cited by
- 228
- References
- 2
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Krebs, M. R. H., Morozova‐Roche, L. A., Daniel, K., Robinson, C. V., & Dobson, C. M. (2004). Observation of sequence specificity in the seeding of protein amyloid fibrils. Protein Science. https://doi.org/10.1110/ps.04707004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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