Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

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Neurodegenerative Diseases Target Large-Scale Human Brain Networks

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Aggresomes: A Cellular Response to Misfolded Proteins

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Mice devoid of PrP are resistant to scrapie

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Aβ Oligomers – a decade of discovery

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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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Transmission and spreading of tauopathy in transgenic mouse brain

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Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

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MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins

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Unfolding the role of protein misfolding in neurodegenerative diseases

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Alzheimer’s disease β-amyloid peptides are released in association with exosomes

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Amyloid pores from pathogenic mutations

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Propagation of Tau Misfolding from the Outside to the Inside of a Cell

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Amyloid β-Protein Fibrillogenesis

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Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

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Cells release prions in association with exosomes

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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

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Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

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Amyloid β-Protein and the Genetics of Alzheimer's Disease

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In Vitro Generation of Infectious Scrapie Prions

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Prion-like transmission of protein aggregates in neurodegenerative diseases

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Prions hijack tunnelling nanotubes for intercellular spread

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Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans

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α‐Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

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Alternative conformations of amyloidogenic proteins govern their behavior

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Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

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Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease

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Iatrogenic Creutzfeldt–Jakob disease at the millennium

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Transmission of prion diseases by blood transfusion

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Prions: Protein Aggregation and Infectious Diseases

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Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease

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Assembly of Aβ Amyloid Protofibrils: An in Vitro Model for a Possible Early Event in Alzheimer's Disease

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Alzheimer disease models and human neuropathology: similarities and differences

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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

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The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

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Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein

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Evidence for Seeding of β-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in β-Amyloid Precursor Protein-Transgenic Mice

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Prefibrillar Amyloid Protein Aggregates Share Common Features of Cytotoxicity

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Protein Misfolding and Neurodegeneration

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Protein misfolding and disease; protein refolding and therapy

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Insights into prion strains and neurotoxicity

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Detection of prions in blood

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Mouse models of Huntington's disease

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Seeding induced by α‐synuclein oligomers provides evidence for spreading of α‐synuclein pathology

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Transmissibility of systemic amyloidosis by a prion-like mechanism

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Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

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In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers

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Animal models of Parkinson’s disease progression

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Observation of sequence specificity in the seeding of protein amyloid fibrils

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Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay

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Prions in Skeletal Muscles of Deer with Chronic Wasting Disease

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Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of α-Synuclein

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The Genetics of the Amyloidoses

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Islet Amyloid Polypeptide (IAPP) Transgenic Rodents as Models for Type 2 Diabetes

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Transmission and Detection of Prions in Feces

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Autophagy and misfolded proteins in neurodegeneration

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Extracellular amyloid formation and associated pathology in neural grafts

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Protein misfolding disorders and macroautophagy

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Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease

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Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease

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Detection of infectious prions in urine

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Protein Misfolding and Disease

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Transmission of Mouse Senile Amyloidosis

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Exosomes: A Bubble Ride for Prions?

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Subcellular Localization of Disease-Associated Prion Protein in the Human Brain

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Tunnelling nanotubes

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Paracrine Diffusion of PrPC and Propagation of Prion Infectivity by Plasma Membrane-Derived Microvesicles

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Variant Creutzfeldt–Jakob disease and its transmission by blood

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Prion Protein Transgenes and the Neuropathology in Prion Diseases

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Transmission of Amyloidosis in Offspring of Mice with AApoAII Amyloidosis

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ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures

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Transmission of circulating cell-free AA amyloid oligomers in exosomes vectors via a prion-like mechanism

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Generation of prions in vitro and the protein-only hypothesis

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Hen or Egg?

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Exploring prion protein biology in flies

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Spreading of prions from the immune to the peripheral nervous system: a potential implication of dendritic cells

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Cellular prion protein released on exosomes from macrophages binds to Hsp70

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Genetic dissection of primary neurodegenerative diseases

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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

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Stem cell aging: mechanisms, regulators and therapeutic opportunities

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Traumatic Brain Injury Induces Tau Aggregation and Spreading

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Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

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Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

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Tunneling nanotubes: The transport highway for astrocyte-neuron communication in the central nervous system

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

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