Prolapse and sexual function in women with benign joint hypermobility syndrome
Abstract
Objective: To determine whether pelvic organ prolapse (POP) and sexual dysfunction are more severe in women with benign joint hypermobility syndrome (BJHS) than in the normal population. Design: Case–control study. Setting: K ing's C ollege H ospital NHS Foundation Trust, L ondon, UK and U niversity C ollege H ospital, L ondon, UK. Population: Women diagnosed with BJHS (n = 60) at U niversity C ollege H ospital. Control participants (n = 60) recruited from K ing's C ollege H ospital NHS Foundation Trust. Methods: Objective assessment of POP was undertaken using the Pelvic Organ Prolapse Quantification System (POP‐Q). Both groups were asked to complete the Prolapse quality of life (P‐QOL) and pelvic organ prolapse/urinary incontinence sexual (PISQ‐12) questionnaires. Main outcome measures: Comparison of vaginal anatomy using POP‐Q between the two groups. Comparison of P‐QOL and PISQ‐12 quality of life scores between the two groups. Results: In all, 120 women (60 in Study group, 60 in Control group) were recruited. All women in the study group were matched with healthy control women according to age, parity and ethnicity. There was a statistically significant difference between points A a, B a, A p, B p and C in study and control groups showing that prolapse is objectively more severe in those with BJHS. Significantly more women with BJHS felt that POP interfered with sex and defecation compared with the control group. The impact of prolapse symptoms on quality of life was statistically different in almost all nine P‐QOL domains. Conclusions: A large number of women with BJHS have prolapse symptoms, which significantly affect their quality of life. POP is more severe in women with BJHS.
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These individuals were more likely to experience symptoms of obstructive defecation on questioning (23% vs 5%, P = 0.007).
“These individuals were also more likely to experience symptoms of obstructive defecation on questioning (23% vs 5%, P = 0.007). 31”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [31]
Pelvic organ prolapse occurs about twice as often in patients with HSD/hEDS compared with non-HSD/hEDS individuals.
“Pelvic organ prolapse : This occurs about twice as often in patients with HSD/hEDS compared with non‐HSD/hEDS individuals.”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [31]
In a case-control study of 60 females referred to a tertiary hypermobility clinic, 73% had clinically significant prolapse compared with 35% of age- and sex-matched healthy controls (P < 0.001).
“For example, in a case–control study of 60 females referred to a tertiary hypermobility clinic, 73% had clinically‐significant prolapse compared with 35% of the age‐matched and sex‐matched healthy controls (P < 0.001). 31”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [31]
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- Authors
- Mastoroudes, H., Giarenis, I., Cardozo, L., Srikrishna, S., Vella, M., Robinson, D., Kazkaz, H., & Grahame, R.
- Affiliations
- King's College Hospital NHS Foundation Trust (GB)
- University College Hospital (GB)
- Corresponding author
- Mastoroudes, H
- ORCID
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2012-12-14
- Volume
- 120
- Issue
- 2
- Pages
- 187-192
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W1993692625
- Cited by
- 38
- References
- 29
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- King's College Hospital Trust (2010-11)
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- benign joint hypermobility syndrome, pelvic organ prolapse, sexual dysfunction, quality of life, pelvic floor, POP-Q, PISQ-12, defecation symptoms, women
- MeSH terms
- Adolescent, Adult, Ehlers-Danlos Syndrome, Female, Health Surveys, Humans, Middle Aged, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Sexual Dysfunction, Physiological, Syndrome, Prevalence, Case-Control Studies, Young Adult, Pelvic Organ Prolapse
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