The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Possible Function of Structural Lipids in the Water-Holding Properties of the Stratum Corneum
Open accessAbstract
In order to clarify the possible role of lipids in the water-holding property of stratum corneum, the forearm skin of 6 healthy male volunteers was treated with acetone/ether (1/1) for 1, 5, 10, and 20 min. A prolonged treatment period of 5-20 min produced a chapped and scaly appearance of the stratum corneum without any inflammatory reactions. Under these conditions, there was a marked decrease in the water-holding capacity of the stratum corneum accompanied by a considerable and selective loss of intercellular lipids such as cholesterol, cholesterol esters, and phospholipids. These impairments persisted until day 4 after treatment. Electron microscopic observation of the altered stratum corneum revealed that naturally occurring intercellular materials were absent, leaving the area with the appearance of a vacant space. These findings suggest an additional and essential role of the specific structural lipids for the water-holding properties of the stratum corneum.
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Citations
Cites
Lipid composition and metabolism in normal and diseased epidermis
Yardley, H. J., & Summerly, R. (1981) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(81)90006-1 · Cited by 267
Cited by
Stratum corneum lipids: the effect of ageing and the seasons
Rogers, J., Harding, C., Mayo, A., Banks, J., & Rawlings, A. (1996) · Archives of Dermatological Research · doi:10.1007/bf02505294 · Cited by 415
Transepidermal water loss: the signal for recovery of barrier structure and function.
Grubauer, G., Elias, P. M., & Feingold, K. R. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38361-9 · Cited by 411
Ananthapadmanabhan, K. P., Moore, D. J., Subramanyan, K., Misra, M., & Meyer, F. (2004) · Dermatologic Therapy · doi:10.1111/j.1396-0296.2004.04s1002.x · Cited by 375
Structure of Water, Proteins, and Lipids in Intact Human Skin, Hair, and Nail
Gniadecka, M., Nielsen, O. F., Christensen, D. H., & Wulf, H. C. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00146.x · Cited by 351
Water temperature as a factor in handwashing efficacy
Michaels, B., Gangar, V., Schultz, A., Arenas, M., Curiale, M., Ayers, T., & Paulson, D. (2002) · Food Service Technology · doi:10.1046/j.1471-5740.2002.00043.x · Cited by 47
Metadata
- Authors
- Imokawa, G., & Hattori, M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 1985-04
- Volume
- 84
- Issue
- 4
- Pages
- 282-284
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2117193543
- Cited by
- 186
- References
- 1
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Imokawa, G., & Hattori, M. (1985). A Possible Function of Structural Lipids in the Water-Holding Properties of the Stratum Corneum. Journal of Investigative Dermatology. https://doi.org/10.1111/1523-1747.ep12265365
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
