The relationship of transepidermal water loss to skin temperature in psoriasis and eczema
Open accessAbstract
Transepidermal water losses (TEWL) from psoriatic and eczematous skin were measured while skin temperature was varied between 29 degrees C and 37 degrees C. The relationship of TEWL to skin temperature in these diseases is different from that obtaining in normal skin. These differences are thought to be due to the altered filtration properties of diseased stratum corneum. Formulae were devised to allow TEWL rates in psoriasis and eczema to be expressed at a standard temperature for comparative purposes.
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Low humidity environments can lead to increased transepidermal water loss, skin dryness, and barrier dysfunction worsening conditions such as atopic dermatitis and psoriasis.
“In low humidity environments it can lead to increased transepidermal water loss, skin dryness, and barrier dysfunction worsening conditions such as atopic dermatitis and psoriasis [45,46].”
From The Environmental Determinants of Skin Health: Linking Climate Change, Air Pollution, and the Dermatologic Disease Burden (2025) · cites this paper as [46]
The Results report higher transepidermal water loss in psoriatic and eczematous skin than in normal skin, and the Discussion describes altered properties of the diseased stratum corneum (page numbers unavailable). Materials and Methods records room humidity but does not test whether low humidity causes increased water loss, dryness, barrier dysfunction, or worsening of either condition. (LLM, conf=0.86)
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Cites
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Self-citationTRANSEPIDERMAL WATER LOSS IN PATIENTS WITH DERMATITIS
SHAHIDULLAG, M., Raffle, E. J., & Frain-Bell, W. (1969) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1969.tb15931.x · Cited by 94 · see citing works
Skin water loss and accidental hypothermia in psoriasis, ichthyosis, and erythroderma.
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Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
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Moisturizers: Reality and the skin benefits
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The impact of temperature on the skin barrier and atopic dermatitis
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Zieneldien, T., Ma, S., Tan, I. J., Kim, J., Busot, D., & Cohen, B. A. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22121820 · Cited by 7 · see citing works
“In low humidity environments it can lead to increased transepidermal water loss, skin dryness, and barrier dysfunction worsening conditions such as atopic dermatitis and psoriasis [45,46].”
- Authors
- Grice, K., Sattar, H., Baker, H., & Sharratt, M.
- Affiliations
- Royal London Hospital (GB)
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 1975-05
- Volume
- 64
- Issue
- 5
- Pages
- 313-315
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2074646119
- Semantic Scholar
- e137937ea48f15e8f72a4c0c1417ce1c66687e75
- Cited by
- 65
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- transepidermal water loss, skin temperature, psoriasis, atopic dermatitis, stratum corneum, skin barrier function
- MeSH terms
- Eczema, Humans, Models, Biological, Psoriasis, Skin Temperature, Water Loss, Insensible
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