In vitro fermentation and prebiotic potential of novel low molecular weight polysaccharides derived from agar and alginate seaweeds
Abstract
Fermentation properties and prebiotic potential of novel low molecular weight polysaccharides (LMWPs) derived from agar and alginate bearing seaweeds was investigated. Ten LMWPs were supplemented to pH, temperature controlled anaerobic batch cultures inoculated with human feces from three donors, in triplicate. Microbiota changes were monitored using Fluorescent in-situ hybridization and short chain fatty acids, the fermentation end products were analysed using gas chromatography. Of the ten LMWPs tested, Gelidium seaweed CC2253 of molecular weight 64.64 KDa showed a significant increase in bifidobacterial populations from log(10) 8.06 at 0 h to log(10) 8.55 at 24 h (p = 0.018). For total bacterial populations, alginate powder CC2238 produced a significant increase from log(10) 9.01 at 0 h to log(10) 9.58 at 24 h (p = 0.032). No changes were observed in the other bacterial groups tested viz. Bacteroides, Lactobacilli/Enterococci, Eubacterium rectale/Clostridium coccoides and Clostridium histolyticum. The polysaccharides also showed significant increases in total SCFA production, particularly acetic and propionic acids, indicating that they were readily fermented. In conclusion, some LMWPs derived from agar and alginate bearing seaweeds were fermented by gut bacteria and exhibited potential to be used a novel source of prebiotics.
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Most seaweed polysaccharides cannot be digested by humans and can be considered dietary fiber, constituting 33%-75% of total composition; soluble fractions account for 50%-85% of total dietary fiber content.
“One of the most important nutritionally relevant components of seaweeds are polysaccharides, most of them cannot be digested by humans, and thus, they can be considered as dietary fiber (33%–75% of the total composition) [96,97]. In turn, soluble fractions account between 50% and 85% of total dietary fiber content [96].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [97]
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- Authors
- Ramnani, P., Chitarrari, R., Tuohy, K., Grant, J., Hotchkiss, S., Philp, K., Campbell, R., Gill, C., & Rowland, I.
- Affiliations
- University of Reading (GB)
- Fondazione Edmund Mach (IT)
- CyberColloids (IE)
- University of Ulster (GB)
- Corresponding author
- Ramnani, Priya
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 18
- Issue
- 1
- Pages
- 1-6
- ISSN
- 1075-9964 (ISSN-L)
- OpenAlex
- W2145123908
- Cited by
- 252
- References
- 32
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 21 · 2020: 26 · 2019: 20 · 2018: 16 · 2017: 21 · 2016: 19 · 2015: 13 · 2014: 13 · 2013: 6 · 2012: 9
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anaerobe (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (Fondazione Edmund Mach) (submittedVersion)
- Funders
- European Commission
- Research Executive Agency
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- low molecular weight polysaccharides, agar, alginate, seaweed, prebiotics, human fecal microbiota, short-chain fatty acids, Bifidobacterium, anaerobic batch culture, Gelidium, Bacteroides, Clostridium histolyticum
- MeSH terms
- Adult, Agar, Fatty Acids, Volatile, Feces, Female, Fermentation, Humans, Male, Molecular Weight, Polysaccharides, Seaweed, Time Factors, Gastrointestinal Tract, Metagenome, Prebiotics, Batch Cell Culture Techniques
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