The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
Yeast lipid metabolism at a glance
Open accessAbstract
During the last decades, lipids have gained much attention due to their involvement in health and disease. Lipids are required for the formation of membranes and contribute to many different processes such as cell signaling, energy supply, and cell death. Various organelles such as the endoplasmic reticulum, mitochondria, peroxisomes, and lipid droplets are involved in lipid metabolism. The yeast Saccharomyces cerevisiae has become a reliable model organism to study biochemistry, molecular biology, and cell biology of lipids. The availability of mutants bearing defects in lipid metabolic pathways and the ease of manipulation by culture conditions facilitated these investigations. Here, we summarize the current knowledge about lipid metabolism in yeast. We grouped this large topic into three sections dealing with (1) fatty acids; (2) membrane lipids; and (3) storage lipids. Fatty acids serve as building blocks for the synthesis of membrane lipids (phospholipids, sphingolipids) and storage lipids (triacylglycerols, steryl esters). Phospholipids, sterols, and sphingolipids are essential components of cellular membranes. Recent investigations addressing lipid synthesis, degradation, and storage as well as regulatory aspects are presented. The role of enzymes governing important steps of the different lipid metabolic pathways is described. Finally, the link between lipid metabolic and dynamic processes is discussed.
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“Lipid droplets not only play an important role in overcoming the potential toxic effect of abnormal sterols and free fatty acids (FA), but also affect cellular energy homeostasis and lipid metabolism.”
From The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn (2016) · cites this paper as [51]
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Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae
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Metadata
- Authors
- Klug, L., & Daum, G.
- Affiliations
- Graz University of Technology (AT)
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-03-05
- Volume
- 14
- Issue
- 3
- Pages
- 369-388
- ISSN
- 1567-1356 (ISSN-L)
- OpenAlex
- W2004399350
- Cited by
- 349
- References
- 225
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 26 · 2023: 28 · 2022: 40 · 2021: 52 · 2020: 33 · 2019: 45 · 2018: 26 · 2017: 23 · 2016: 11 · 2015: 12 · 2014: 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- lipid metabolism, Saccharomyces cerevisiae, fatty acids, membrane lipids, storage lipids, phospholipids, sphingolipids, triglycerides, sterol esters, lipogenesis, lipid degradation, lipid metabolism enzymes, lipid metabolism regulation, lipid droplets, peroxisomes, endoplasmic reticulum, mitochondria
- MeSH terms
- Saccharomyces cerevisiae, Lipid Metabolism, Metabolic Networks and Pathways
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