Cited by 100Cancer Immunotherapy and BiomarkersColorectal Cancer Treatments and StudiesFerroptosis and cancer prognosis

Rise of PD-L1 expression during metastasis of colorectal cancer: Implications for immunotherapy

Wang, Huan Bin, Yao, Han, Li, Chu Shu, Liang, Lun Xi, Zhang, Yao, Chen, Ying Xuan, Fang, Jing‐Yuan, Xu, Jie·2017·Journal of Digestive Diseases

Abstract

OBJECTIVE: Programmed death‐ligand 1 (PD‐L1) expression in colorectal cancer (CRC) was implicated in predicting anti‐PD‐1/PD‐L1 therapy efficacy. However, therapeutic response has also been found in patients without PD‐L1 expression in the primary tumor. In the present study, we aimed to clarify the prevalence of PD‐L1 in primary and metastatic CRC. METHODS: The expression of PD‐L1 was determined by immunohistochemistry in matched primary and metastatic CRC. RESULTS: PD‐L1 expression was significantly more prevalent in metastatic CRCs than in primary tumors, and the expression of PD‐L1 in primary CRC may not represent the tumors that spread to distant organs. Positive expression of PD‐L1 was found in 81.8% of metastatic CRC, being significantly more prevalent than in primary CRC (40.9%; P = 0.012, Fisher’s exact test). While comparing the primary and metastatic lesions of the same patients, we found that PD‐L1 expression frequently increased during the metastatic process. However, PD‐L1 expression was rarely decreased in metastatic lesions. Intratumoral heterogeneity expression of PD‐L1 was found in both metastatic CRC (22.2%) and primary CRCs (33.3%). PD‐L1 was prevalently expressed in metastatic CRC, and increased PD‐L1 expression was frequently found in metastatic CRC as compared to primary tumors. CONCLUSION: PD‐L1 expression in metastatic CRC should be considered as an independent factor while evaluating the suitability of patients for immunotherapy.

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Crossref · 10.1111/1751-2980.12538

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Authors
Wang, H. B., Yao, H., Li, C. S., Liang, L. X., Zhang, Y., Chen, Y. X., Fang, J., & Xu, J.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease Shanghai China
Corresponding author
Xu, Jie
Venue
Journal of Digestive Diseases
Publisher
Wiley
Published
2017-10
Volume
18
Issue
10
Pages
574-581
ISSN
  • 1751-2972 (ISSN-L)
  • 1751-2980
OpenAlex
W2752071552
Cited by
100
References
34
Citations by year
2026: 3 · 2025: 10 · 2024: 16 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 17 · 2019: 11 · 2018: 11
FWCI
4.70
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Digestive Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81572326, 81322036, 81272383, 81602518, 81502015, 81572303, 81530072, 81421001, 81320108024)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords
PD-L1 expression, colorectal cancer, metastasis, primary tumor, intratumoral heterogeneity, PD-1/PD-L1 blockade, predictive biomarkers, tumor immune evasion
MeSH terms
Aged, Female, Humans, Immunohistochemistry, Immunotherapy, Male, Middle Aged, Neoplasm Metastasis, Colorectal Neoplasms, B7-H1 Antigen

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