Diet, microorganisms and their metabolites, and colon cancer
Open accessAbstract
Colorectal cancer is one of the so-called westernized diseases and the second leading cause of cancer death worldwide. On the basis of global epidemiological and scientific studies, evidence suggests that the risk of colorectal cancer is increased by processed and unprocessed meat consumption but suppressed by fibre, and that food composition affects colonic health and cancer risk via its effects on colonic microbial metabolism. The gut microbiota can ferment complex dietary residues that are resistant to digestion by enteric enzymes. This process provides energy for the microbiota but culminates in the release of short-chain fatty acids including butyrate, which are utilized for the metabolic needs of the colon and the body. Butyrate has a remarkable array of colonic health-promoting and antineoplastic properties: it is the preferred energy source for colonocytes, it maintains mucosal integrity and it suppresses inflammation and carcinogenesis through effects on immunity, gene expression and epigenetic modulation. Protein residues and fat-stimulated bile acids are also metabolized by the microbiota to inflammatory and/or carcinogenic metabolites, which increase the risk of neoplastic progression. This Review will discuss the mechanisms behind these microbial metabolite effects, which could be modified by diet to achieve the objective of preventing colorectal cancer in Western societies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Short-chain fatty acids maintain gut health by promoting intestinal barrier integrity, mucus production, and supporting a tolerogenic response over inflammation.
“SCFAs maintain gut health by promoting intestinal barrier integrity, mucus production, and supporting a tolerogenic response over inflammation (49, 50, 98, 99).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,271 · see citing works
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927 · see citing works
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,520 · see citing works
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
Origins and evolution of the Western diet: health implications for the 21st century1,2
Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397 · see citing works
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works
Xu, D., He, X., Chang, Y., Sun, S., Xu, C., & Lin, J. (2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977 · see citing works
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works
Wang, D., & DuBois, R. N. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2809 · Cited by 1,794 · see citing works
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771 · see citing works
Benefits of polyphenols on gut microbiota and implications in human health
Cardona, F., Andrés‐Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.05.001 · Cited by 1,615 · see citing works
Position of the American Dietetic Association
Marlett, J. A., McBurney, M. I., & Slavin, J. L. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90228-2 · Cited by 1,468 · see citing works
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287 · see citing works
Willett, W. C., Stampfer, M. J., Colditz, G. A., ROSNER, B. A., & Speizer, F. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012133232404 · Cited by 1,239 · see citing works
Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon
Roediger, W. E. W. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80339-9 · Cited by 1,201 · see citing works
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works
Aune, D., Chan, D. S. M., Lau, R., Vieira, R., Greenwood, D. C., Kampman, E., & Norat, T. (2011) · BMJ · doi:10.1136/bmj.d6617 · Cited by 1,146 · see citing works
Simopoulos, A. P. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.080 · Cited by 1,143 · see citing works
Berg, D., Davidson, N. M., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M. W., & Rennick, D. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118861 · Cited by 1,125 · see citing works
Collado, M. C., Rautava, S., Aakko, J., Isolauri, E., & Salminen, S. (2016) · Scientific Reports · doi:10.1038/srep23129 · Cited by 1,098 · see citing works
Links between diet, gut microbiota composition and gut metabolism
Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2015) · Proceedings of the Nutrition Society · doi:10.1017/s0029665114001463 · Cited by 1,020 · see citing works
Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W., & Bultman, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.033 · Cited by 993 · see citing works
Fat, fibre and cancer risk in African Americans and rural Africans
O’Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7342 · Cited by 982 · see citing works
Self-citationBacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970 · see citing works
Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941 · see citing works
Lack of Effect of a Low-Fat, High-Fiber Diet on the Recurrence of Colorectal Adenomas
Schatzkin, A. G., Lanza, E., Corle, D. K., Lance, P., Iber, F. L., Caan, B. J., Shike, M., Weissfeld, J. L., Burt, R. W., Cooper, M. R., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004203421601 · Cited by 928 · see citing works
Mirvish, S. S. (1995) · Cancer Letters · doi:10.1016/0304-3835(95)03786-v · Cited by 916 · see citing works
Scientific Opinion on Dietary Reference Values for carbohydrates and dietary fibre
EFSA Panel on Dietetic Products, N. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1462 · Cited by 912 · see citing works
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · see citing works
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Beyaz, S., Mana, M., Roper, J., Kedrin, D., Saadatpour, A., Hong, S., Bauer-Rowe, K. E., Xifaras, M. E., Akkad, A., Arias, E., et al. (2016) · Nature · doi:10.1038/nature17173 · Cited by 840 · see citing works
Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775 · see citing works
The Gut Microbiome Modulates Colon Tumorigenesis
Zackular, J. P., Baxter, N. T., Iverson, K. D., Sadler, W. D., Petrosino, J. F., Chen, G., & Schloss, P. D. (2013) · mBio · doi:10.1128/mbio.00692-13 · Cited by 717 · see citing works
Relevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692 · see citing works
Comparison of fermentation reactions in different regions of the human colon
Macfarlane, G. T., Gibson, G. R., & Cummings, J. H. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb04882.x · Cited by 676 · see citing works
Queipo-Ortuño, M. I., Boto-Ordóñez, M., Murri, M., Gomez-Zumaquero, J. M., Clemente-Postigo, M., Estruch, R., Cardona Diaz, F., Andrés-Lacueva, C., & Tinahones, F. J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027847 · Cited by 671 · see citing works
<i>Fusobacterium nucleatum</i> and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works
Position of the American Dietetic Association: Health Implications of Dietary Fiber
(2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.08.007 · Cited by 654 · see citing works
Ou, J., Carbonero, F., Zoetendal, E. G., DeLany, J. P., Wang, M., Newton, K., Gaskins, H. R., & O’Keefe, S. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.056689 · Cited by 646 · see citing works
Self-citationWaldecker, M., Kautenburger, T., Daumann, H., Busch, C., & Schrenk, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.002 · Cited by 615 · see citing works
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614 · see citing works
Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients
Rafter, J. J., Bennett, M., Caderni, G., Clune, Y., Hughes, R., Karlsson, P. C., Klinder, A., O'Riordan, M., O’Sullivan, G. C., Pool-Zobel, B. L., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.488 · Cited by 591 · see citing works
Microbiota of Human Breast Tissue
Urbaniak, C., Cummins, J., Brackstone, M., Macklaim, J. M., Gloor, G. B., Baban, C. K., Scott, L., O'Hanlon, D. M., Burton, J. P., Francis, K. P., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00242-14 · Cited by 552 · see citing works
Hinnebusch, B. F., Meng, S., Wu, J. T., Archer, S. Y., & Hodin, R. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.1012 · Cited by 546 · see citing works
Microbial Dysbiosis Is Associated with Human Breast Cancer
Xuan, C., Shamonki, J. M., Chung, A., DiNome, M. L., Chung, M., Sieling, P. A., & Lee, D. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083744 · Cited by 543 · see citing works
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Inan, M. S., Rasoulpour, R. J., Yin, L., Hubbard, A. K., Rosenberg, D. W., & Giardina, C. A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70142-9 · Cited by 502 · see citing works
Prevalence of obesity among adults: United States, 2011-2012.
Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2013) · PubMed · Cited by 502 · see citing works
Donohoe, D. R., Holley, D., Collins, L. B., Montgomery, S. A., Whitmore, A. C., Hillhouse, A., Curry, K. P., Renner, S. W., Greenwalt, A., Ryan, E. P., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0501 · Cited by 479 · see citing works
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Surendra, A., Kumar, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.051 · Cited by 473 · see citing works
<i>Fusobacterium</i> in Colonic Flora and Molecular Features of Colorectal Carcinoma
Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H.-O., Sugai, T., An, B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1865 · Cited by 465 · see citing works
A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01494.x · Cited by 454 · see citing works
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
Schulz, M. D., Atay, Ç., Heringer, J., Romrig, F., Schwitalla, S., Aydın, B., Ziegler, P. K., Varga, J., Reindl, W., Pommerenke, C., et al. (2014) · Nature · doi:10.1038/nature13398 · Cited by 452 · see citing works
Meat‐related mutagens/carcinogens in the etiology of colorectal cancer
Cross, A. J., & Sinha, R. R. (2004) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20030 · Cited by 439 · see citing works
Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility
Uronis, J. M., Mühlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S., & Jobin, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006026 · Cited by 425 · see citing works
Digestion and physiological properties of resistant starch in the human large bowel
Cummings, J. H., Beatty, E. R., Kingman, S. M., Bingham, S. A., & Englyst, H. N. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960177 · Cited by 409 · see citing works
Macfarlane, G. T., & Macfarlane, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31822fecfe · Cited by 406 · see citing works
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396 · see citing works
Schauber, J. (2003) · Gut · doi:10.1136/gut.52.5.735 · Cited by 383 · see citing works
Evidence That Hydrogen Sulfide Is a Genotoxic Agent
Attene‐Ramos, M. S., Wagner, E. D., Plewa, M. J., & Gaskins, H. R. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0126 · Cited by 363 · see citing works
The COGENT Consortium, Houlston, R. S., The CORGI Consortium, The COIN Collaborative Group, The COINB Collaborative Group, Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., et al. (2010) · Nature Genetics · doi:10.1038/ng.670 · Cited by 360 · see citing works
A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate
Fung, K. Y. C., Cosgrove, L. J., Lockett, T. J., Head, R. J., & Topping, D. L. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001948 · Cited by 357 · see citing works
Carcinogenicity of deoxycholate, a secondary bile acid
Bernstein, C., Holubec, H., Bhattacharyya, A. K., Nguyen, H., Payne, C. M., Zaitlin, B., & Bernstein, H. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0648-7 · Cited by 351 · see citing works
Scharlau, D., Borowicki, A., Habermann, N., Hofmann, T., Klenow, S., Miene, C., Munjal, U., Stein, K., & Glei, M. (2009) · Mutation research · doi:10.1016/j.mrrev.2009.04.001 · Cited by 346 · see citing works
Nosho, K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.557 · Cited by 344 · see citing works
Rook, G. A. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04133.x · Cited by 332 · see citing works
Chen, H.-M., Yu, Y.-N., Wang, J.-L., Lin, Y.-W., Kong, X., Yang, C.-Q., Yang, L., Liu, Z.-J., Yuan, Y.-Z., Liu, F., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.046607 · Cited by 321 · see citing works
Pischon, T., Nöthlings, U., & Boeing, H. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108006976 · Cited by 320 · see citing works
Bingham, S. A., Pignatelli, B., Pollock, J. R. A., Ellul, A., MALAVEILLE, C., Gross, G., Runswick, S. A., Cummings, J. H., & O'Neill, I. K. (1996) · Carcinogenesis · doi:10.1093/carcin/17.3.515 · Cited by 312 · see citing works
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats
Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.012 · Cited by 308 · see citing works
The gut microbiome and obesity
John, G. K., & Mullin, G. E. (2016) · Current Oncology Reports · doi:10.1007/s11912-016-0528-7 · Cited by 304 · see citing works
Cancer-promoting effects of microbial dysbiosis
Sheflin, A. M., Whitney, A. K., & Weir, T. L. (2014) · Current Oncology Reports · doi:10.1007/s11912-014-0406-0 · Cited by 301 · see citing works
Baxter, N. T., Zackular, J. P., Chen, G. Y., & Schloss, P. D. (2014) · Microbiome · doi:10.1186/2049-2618-2-20 · Cited by 299 · see citing works
Gressley, T. F., Hall, M. B., & Armentano, L. E. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-3460 · Cited by 289 · see citing works
Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal
Bui, T. P. N., Ritari, J., Boeren, S. A., de Waard, P., Plugge, C. M., & de Vos, W. M. (2015) · Nature Communications · doi:10.1038/ncomms10062 · Cited by 272 · see citing works
Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers.
Venter, C. S., Vorster, H., & Cummings, J. H. (1990) · PubMed · Cited by 269 · see citing works
Ungar, P. S., & Sponheimer, M. (2011) · Science · doi:10.1126/science.1207701 · Cited by 269 · see citing works
Starch utilization by the human large intestinal microflora
Macfarlane, G. T., & Englyst, H. N. (1986) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1986.tb01073.x · Cited by 265 · see citing works
Effect of resistant starch on colonic fermentation, bile acid metabolism, and mucosal proliferation
van Munster, I. P., Tangerman, A., & Nagengast, F. M. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087431 · Cited by 253 · see citing works
Resistant starch lowers fecal concentrations of ammonia and phenols in humans
Birkett, A., Muir, J. G., Phillips, J. R., Jones, G., & O’Dea, K. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.766 · Cited by 241 · see citing works
Hylla, S., Gostner, A., Dusel, G., Anger, H. J. W., Bartram, H.-P., Christl, S., Kasper, H., & Scheppach, W. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.1.136 · Cited by 241 · see citing works
Diet and cell growth modulation by ammonia
Visek, W. J. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.10.s216 · Cited by 237 · see citing works
Hu, S., Dong, T. S., Dalal, S. R., Wu, F., Bissonnette, M., Kwon, J. H., & Chang, E. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016221 · Cited by 231 · see citing works
Dietary patterns and colorectal cancer
Magalhães, B. M. B. D. S., Peleteiro, B., & Lunet, N. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3283472241 · Cited by 224 · see citing works
Does butyrate protect from colorectal cancer?
Sengupta, S., Muir, J. G., & Gibson, P. R. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04213.x · Cited by 219 · see citing works
Nutrition and colonic health: the critical role of the microbiota
O’Keefe, S. J. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f323f3 · Cited by 217 · see citing works
Self-citationDietary patterns and colorectal cancer
Tayyem, R., Bawadi, H. A., Shehadah, I., Agraib, L. M., AbuMweis, S. S., Al‐Jaberi, T., Al-Nusairr, M., Bani-Hani, K. E., & Heath, D. D. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.04.029 · Cited by 209 · see citing works
Comalada, M., Bailón, E., de Haro, O., Lara‐Villoslada, F., Xaus, J., Zarzuelo, A., & Gálvez, J. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0092-x · Cited by 207 · see citing works
Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities
Kemperman, R., Bolca, S., Roger, L. C., & Vaughan, E. E. (2010) · Microbiology · doi:10.1099/mic.0.042127-0 · Cited by 202 · see citing works
Colnot, S., Niwa‐Kawakita, M., Hamard, G., Godard, C., Plénier, S. L., Houbron, C., Romagnolo, B., Berrebi, D. D., Giovannini, M., & Perret, C. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700180 · Cited by 197 · see citing works
Importance of colonic support for energy absorption as small-bowel failure proceeds
Nordgaard, I., Hansen, B. S., & Mortensen, P. B. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.2.222 · Cited by 192 · see citing works
Role of colonic microbiota in colorectal carcinogenesis: A systematic review
Borges‐Canha, M. (2015) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2015.3830/2015 · Cited by 192 · see citing works
Hu, S., Liu, L., Chang, E. B., Wang, J., & Raufman, J. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0450-x · Cited by 185 · see citing works
The Gut Microbiota and Developmental Programming of the Testis in Mice
Al-Asmakh, M., Stukenborg, J.-B., Reda, A., Anuar, F., Strand, M.-L., Hedin, L., Pettersson, S., & Söder, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103809 · Cited by 173 · see citing works
D-Lactic Acidosis: An Underrecognized Complication of Short Bowel Syndrome
Kowlgi, G. N., & Chhabra, L. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/476215 · Cited by 169 · see citing works
Cancer prevention with freeze-dried berries and berry components
STONER, G., Wang, L., Zikri, N. N., Chen, T., Hecht, S. S., Huang, C., Sardo, C. L., & Lechner, J. F. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.05.001 · Cited by 169 · see citing works
Hu, Y. C., Leu, R. K. L., Christophersen, C. T., Somashekar, R., Conlon, M. A., Meng, X. Q., Winter, J. M., Woodman, R. J., McKinnon, R. A., & Young, G. P. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw019 · Cited by 168 · see citing works
Why Do African Americans Get More Colon Cancer than Native Africans?
O’Keefe, S. J., Chung, D., Mahmoud, N., Sepulveda, A. R., Manafe, M., Arch, J. E., Adada, H., & van der Merwe, T. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.175s · Cited by 167 · see citing works
Self-citationMartin, C. R., Zhang, Y., Tonelli, C., & Petroni, K. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120142 · Cited by 167 · see citing works
Products of the Colonic Microbiota Mediate the Effects of Diet on Colon Cancer Risk ,
O’Keefe, S. J., Ou, J., Aufreiter, S., O’Connor, D. L., Sharma, S. K., Sepulveda, J. L., Fukuwatari, T., Shibata, K., & Mawhinney, T. P. (2009) · Journal of Nutrition · doi:10.3945/jn.109.104380 · Cited by 161 · see citing works
Self-citationBultman, S. J. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2483 · Cited by 157 · see citing works
Wells, J. E., & Hylemon, P. B. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.3.1107-1113.2000 · Cited by 154 · see citing works
Perdue, D. G., Haverkamp, D. S., Perkins, C. I., Daley, C. M., & Provost, E. M. (2014) · American Journal of Public Health · doi:10.2105/ajph.2013.301654 · Cited by 138 · see citing works
Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model
D’Argenio, G., Cosenza, V., Cave, M. D., Iovino, P., Valle, N. D., Lombardi, G., & Mazzacca, G. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964397 · Cited by 136 · see citing works
Guertin, K. A., Loftfield, E., Boca, S. M., Sampson, J. N., Moore, S. C., Xiao, Q., Huang, W.-Y., Xiong, X., Freedman, N. D., Cross, A. J., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.096099 · Cited by 134 · see citing works
McCall, I. C., Betanzos, A., Weber, D. A., Nava, P., Miller, G. W., & Parkos, C. A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.08.002 · Cited by 133 · see citing works
Alberts, D. S., Ritenbaugh, C., Story, J. A., Aickin, M. G., Rees-McGee, S., Buller, M. K., Atwood, J. R., Phelps, J., Ramanujam, P. S., Bellapravalu, S., et al. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.81 · Cited by 132 · see citing works
Bordonaro, M., Lazarova, D. L., & Sartorelli, A. C. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5818 · Cited by 130 · see citing works
Dietary fibre for the prevention of colorectal adenomas and carcinomas
Asano, T. K., & McLeod, R. S. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003430 · Cited by 129 · see citing works
Rodríguez‐Cabezas, M. E., Gálvez, J., Lorente, M., Concha, Á., Camuesco, D., Azzouz, S., Osuna, A., Redondo, L., & Zarzuelo, A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.11.3263 · Cited by 128 · see citing works
Microbial Induction of Immunity, Inflammation, and Cancer
Greer, J. B., & O’Keefe, S. J. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2010.00168 · Cited by 126 · see citing works
Self-citationLanza, E., Hartman, T. J., Albert, P. S., Shields, R., Slattery, M. L., Caan, B. J., Paskett, E. D., Iber, F. L., Kikendall, J. W., Lance, P., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.7.1896 · Cited by 122 · see citing works
Humphreys, K. J., Cobiac, L., Leu, R. K. L., der Hoek, M. B. V., & Michael, M. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21879 · Cited by 117 · see citing works
Modulation of Wnt/ -catenin signaling pathway by bioactive food components
Tarapore, R. S., Siddiqui, I. A., & Mukhtar, H. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr305 · Cited by 117 · see citing works
Evidence for dietary change but not landscape use in South African early hominins
Balter, V., Braga, J., Télouk, P., & Thackeray, F. (2012) · Nature · doi:10.1038/nature11349 · Cited by 116 · see citing works
The microbiota and its metabolites in colonic mucosal health and cancer risk
Vipperla, K., & O'Keefe, S. J. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612452012 · Cited by 116 · see citing works
Self-citationBoever, P. D., Wouters, R., Verschaeve, L., Berckmans, P., Schoeters, G. E. R., & Verstraete, W. (2000) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000330 · Cited by 116 · see citing works
Woodworth, H. L., McCaskey, S., Duriancik, D. M., Clinthorne, J. F., Langohr, I. M., Gardner, E. M., & Fenton, J. I. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1396 · Cited by 115 · see citing works
Diet, microbiota, and dysbiosis: a ‘recipe’ for colorectal cancer
Vipperla, K., & O’Keefe, S. J. (2016) · Food & Function · doi:10.1039/c5fo01276g · Cited by 115 · see citing works
Self-citationToden, S., Bird, A. R., Topping, D. L., & Conlon, M. A. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.3.2382 · Cited by 113 · see citing works
Dietary Manipulation of Oncogenic MicroRNA Expression in Human Rectal Mucosa: A Randomized Trial
Humphreys, K. J., Conlon, M. A., Young, G. P., Topping, D. L., Hu, Y. C., Winter, J. M., Bird, A. R., Cobiac, L., Kennedy, N. A., Michael, M., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0053 · Cited by 113 · see citing works
Rarity of Colon Cancer in Africans Is Associated With Low Animal Product Consumption, Not Fiber
O’Keefe, S. J., Kidd, M. S., Espitalier-Noël, G., & Owira, P. M. O. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01089.x · Cited by 109 · see citing works
Self-citationBeyer-Sehlmeyer, G., Glei, M., Hartmann, E., Hughes, R., Persin, C., Böhm, V., Schubert, R., Jahreis, G., & Pool-Zobel, B. L. (2003) · British Journal Of Nutrition · doi:10.1079/bjn20031003 · Cited by 108 · see citing works
Does digestibility of meat protein help explain large bowel cancer risk?
Silvester, K. R., & Cummings, J. H. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514417 · Cited by 107 · see citing works
Eid, N. M. S., Osmanova, H., Natchez, C., Walton, G., Costabile, A., Gibson, G. R., Rowland, I. R., & Spencer, J. P. E. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002780 · Cited by 103 · see citing works
Giménez‐Bastida, J. A., Larrosa, M., González‐Sarrías, A., Tomás-Barberán, F. A., Espı́n, J. C., & García‐Conesa, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300290f · Cited by 97 · see citing works
Bersamin, A., Luick, B. R., King, I. B., Stern, J. S., & Zidenberg‐Cherr, S. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.10.046 · Cited by 97 · see citing works
Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer
Figueiredo, J. C., Hsu, L., Hutter, C. M., Lin, Y., Campbell, P. T., Baron, J. A., Berndt, S. I., Jiao, S., Casey, G., Fortini, B. K., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004228 · Cited by 97 · see citing works
Clinton, S. K., Bostwick, D. G., OLSON, L. M., Mangian, H. J., & Visek, W. J. (1988) · PubMed · Cited by 97 · see citing works
Higashimura, Y., Naito, Y., Takagi, T., Uchiyama, K., Mizushima, K., Ushiroda, C., Ohnogi, H., Kudo, Y., Yasui, M., Inui, S., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00324.2015 · Cited by 97 · see citing works
Taira, T., Yamaguchi, S., Takahashi, A., et al. (2015) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-15 · Cited by 96 · see citing works
Doll and Peto's Quantitative Estimates of Cancer Risks: Holding Generally True for 35 Years
Blot, W. J., & Tarone, R. E. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv044 · Cited by 95 · see citing works
Park, H., Kim, M., Kwon, G. T., Lim, D. Y., Yu, R., Sung, M., Lee, K. W., Daily, J. W., & Park, J. H. Y. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20856 · Cited by 95 · see citing works
Reddy, B. S., Simi, B., Patel, N. P., Aliaga, C. A., & Rao, C. V. (1996) · PubMed · Cited by 94 · see citing works
Coffee Consumption and the Risk of Colorectal Cancer
Schmit, S. L., Rennert, H. S., Rennert, G., & Gruber, S. B. (2016) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0924 · Cited by 94 · see citing works
Ye, H., Liu, J., Feng, P., et al. (2016) · Scientific Reports · doi:10.1038/srep20329 · Cited by 93 · see citing works
Dietary and biomarker estimates of fatty acids and risk of colorectal cancer
Hodge, A. M., Williamson, E., Bassett, J. K., MacInnis, R. J., Giles, G. G., & English, D. R. (2015) · International Journal of Cancer · doi:10.1002/ijc.29479 · Cited by 92 · see citing works
Molecular Binding of Black Tea Theaflavins to Biological Membranes: Relationship to Bioactivities
Sirk, T. W., Friedman, M., & Brown, E. F. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2006547 · Cited by 88 · see citing works
Shields, C. E. D., Meerbeke, S. W. V., Housseau, F., Wang, H., Huso, D. L., Casero, R. A., O’Hagan, H. M., & Sears, C. L. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw069 · Cited by 88 · see citing works
Zgouras, D., Wächtershäuser, A., Frings, D., & Stein, J. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02916-9 · Cited by 84 · see citing works
Preter, V. D., Geboes, K. P., Verbrugghe, K., Vuyst, L. D., Vanhoutte, T., Huys, G. R. B., Swings, J., Pot, B., & Verbeke, K. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041228 · Cited by 83 · see citing works
Wang, L.-S., Burke, C. A., Hasson, H., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0052 · Cited by 82 · see citing works
Matsuki, T., Pédron, T., Regnault, B., Mulet, C., Hara, T., & Sansonetti, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063053 · Cited by 79 · see citing works
Cancer among circumpolar populations: an emerging public health concern
Young, T. K., Kelly, J. J., Friborg, J., et al. (2016) · International Journal of Circumpolar Health · doi:10.3402/ijch.v75.29787 · Cited by 77 · see citing works
Guercio, B. J., Sato, K., Niedzwiecki, D., Ye, X., Saltz, L. B., Mayer, R. J., Mowat, R. B., Whittom, R., Hantel, A., Benson, A. B., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.5062 · Cited by 74 · see citing works
Inhibition by Resistant Starch of Red Meat–Induced Promutagenic Adducts in Mouse Colon
Winter, J. M., Nyskohus, L. S., Young, G. P., Hu, Y. C., Conlon, M. A., Bird, A. R., Topping, D. L., & Leu, R. K. L. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0176 · Cited by 74 · see citing works
Toden, S., Bird, A. R., Topping, D. L., & Conlon, M. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507336817 · Cited by 73 · see citing works
Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding
Chirakkal, H., Leech, S. H., Brookes, K. E., Prais, A. L., Waby, J. S., & Corfe, B. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209702 · Cited by 72 · see citing works
González‐Sarrías, A., Núñez‐Sánchez, M. Á., Garcı́a-Villalba, R., Tomás-Barberán, F. A., & Espı́n, J. C. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1131-7 · Cited by 72 · see citing works
Dietary polyphenols and colorectal cancer risk: The Fukuoka colorectal cancer study
Wang, Z.-J. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i17.2683 · Cited by 71 · see citing works
Núñez‐Sánchez, M. Á., Karmokar, A., González‐Sarrías, A., Garcı́a-Villalba, R., Tomás-Barberán, F. A., García‐Conesa, M., Brown, K., & Espı́n, J. C. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.03.011 · Cited by 71 · see citing works
Changes seen in gut bacteria content and distribution with obesity: causation or association?
Bell, D. S. H. (2015) · Postgraduate Medicine · doi:10.1080/00325481.2015.1098519 · Cited by 69 · see citing works
Prolonged Butyrate Treatment Inhibits the Migration and Invasion Potential of HT1080 Tumor Cells
Zeng, H., & Briske‐Anderson, M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.291 · Cited by 67 · see citing works
Malago, J. J., Koninkx, J. F. J. G., Tooten, P. C. J., van Liere, E. A., & van Dijk, J. E. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02810.x · Cited by 55 · see citing works
Kim, S., Sandler, D. P., Galanko, J., Martin, C. F., & Sandler, R. S. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq032 · Cited by 54 · see citing works
Elsheikh, W., Blackler, R. W., Flannigan, K. L., & Wallace, J. L. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.04.006 · Cited by 53 · see citing works
The Interrelationships of the Gut Microbiome and Inflammation in Colorectal Carcinogenesis
Cho, M., Carter, J., Harari, S. E., & Pei, Z. (2014) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2014.08.002 · Cited by 51 · see citing works
Kolar, S. S. N., Barhoumi, R., Callaway, E. S., Fan, Y.-Y., Wang, N., Lupton, J. R., & Chapkin, R. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00312.2007 · Cited by 50 · see citing works
Role of bile bacteria in gallbladder carcinoma.
Sharma, V. K., Chauhan, V. S., Nath, G., et al. (2007) · PubMed · Cited by 49 · see citing works
De Preter, V., Arijs, I., Windey, K., Vanhove, W., Vermeire, S., Schuit, F., Rutgeerts, P., & Verbeke, K. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22949 · Cited by 49 · see citing works
Enos, R. T., Velázquez, K. T., McClellan, J. L., Cranford, T. L., Nagarkatti, M., Nagarkatti, P. S., Davis, J. M., & Murphy, E. A. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00345.2015 · Cited by 49 · see citing works
Viggiano, E., Mollica, M. P., Lionetti, L., Cavaliere, G., Trinchese, G., Filippo, C. D., Chieffi, S., Gaita, M., Barletta, A., Luca, B. D., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00150 · Cited by 49 · see citing works
Hofmanov�, J., Vaculov�, A., Lojek, A., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0490-2 · Cited by 47 · see citing works
Bile acids are multifunctional modulators of the Barrett's carcinogenesis.
Burnat, G., Majka, J., & Konturek, P. C. (2010) · PubMed · Cited by 41 · see citing works
Verma, M. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328361dc70 · Cited by 38 · see citing works
Andoh, M. S. A. (2002) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-001-0239-1 · Cited by 35 · see citing works
Coffee Consumption and Risk of Colorectal Cancer: The Japan Collaborative Cohort Study
Yamada, H., Kawado, M., Aoyama, N., Hashimoto, S., Suzuki, K. A. O., Wakai, K., Suzuki, S., Watanabe, Y., & Tamakoshi, A. (2014) · Journal of Epidemiology · doi:10.2188/jea.je20130168 · Cited by 33 · see citing works
Dietary fatty acids, luminal modifiers, and risk of colorectal cancer
Kato, I., Majumdar, A. P. N., Land, S. J., Barnholtz‐Sloan, J. S., & Severson, R. K. (2009) · International Journal of Cancer · doi:10.1002/ijc.25103 · Cited by 32 · see citing works
Hydrogen sulfide-releasing anti-inflammatory drugs for chemoprevention and treatment of cancer
Ianaro, A., Cirino, G., & Wallace, J. L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.07.041 · Cited by 30 · see citing works
[Cancer in Japanese migrants to Hawaii: interaction between genes and environment].
Marchand, L. L., & Kolonel, L. N. (1992) · PubMed · Cited by 28 · see citing works
Goday, A., Barneto, I., García‐Almeida, J. M., Blasco, A., Lecube, A., Grávalos, C., de Icaya, P. M., Peñas, R. D. L., Monereo, S., Vázquez, L., et al. (2015) · Clinical & Translational Oncology · doi:10.1007/s12094-015-1306-y · Cited by 28 · see citing works
Rodríguez-Salvador, J., Armas-Pineda, C., Pérezpeña-Díazconti, M., Chico-Ponce de León, F., Sosa-Sáinz, G., Lezama, P., Targa, F. R., & Arenas‐Huertero, F. (2005) · PubMed · Cited by 23 · see citing works
Moreira, A. P. B., Sabarense, C. M., Dias, C. M. G. C., Lunz, W., Natali, A. J., Glória, M. B. A., & Pelúzio, M. D. C. G. (2009) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2009007500015 · Cited by 22 · see citing works
Li, C., Li, R. W., & Elsasser, T. H. (2010) · Genetics & Epigenetics · doi:10.4137/geg.s6144 · Cited by 11 · see citing works
Diseases of the Alimentary Tract and Western Diets
Burkitt, D. P. (2008) · Pathologia et Microbiologia · doi:10.1159/000162646 · Cited by 11 · see citing works
The african way of life and colon cancer risk
O’Keefe, S. J. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05296.x · Cited by 6 · see citing works
Self-citationThe colon as a metabolic organ.
O’Keefe, S. J. (1994) · PubMed · Cited by 5 · see citing works
Self-citationA.R.P. Walker Lecture. Food and the gut.
O’Keefe, S. J. (1995) · PubMed · Cited by 2 · see citing works
Self-citationSa1465 Obesity and Colon Cancer Risk: Is it the Fat?
Ou, J., Ridlon, J. M., DeLany, J. P., et al. (2012) · Gastroenterology · doi:10.1016/s0016-5085(12)61172-x · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works
The microbiome, cancer, and cancer therapy
Helmink, B. A., Khan, M. A. W., Hermann, A., Gopalakrishnan, V., & Wargo, J. A. (2019) · Nature Medicine · doi:10.1038/s41591-019-0377-7 · Cited by 1,200 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
The Intestinal Microbiota in Colorectal Cancer.
Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777 · see citing works
So, D., Whelan, K., Rossi, M., Morrison, M., Holtmann, G., Kelly, J. T., Shanahan, E. R., Staudacher, H. M., & Campbell, K. L. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy041 · Cited by 683 · see citing works
Nutrition, inflammation and cancer
Zitvogel, L., Pietrocola, F., & Kroemer, G. (2017) · Nature Immunology · doi:10.1038/ni.3754 · Cited by 446 · see citing works
Role of the gut microbiota in type 2 diabetes and related diseases
Yang, G., Wei, J., Liu, P., Zhang, Q., Tian, Y., Hou, G., Meng, L., Xin, Y., & Jiang, X. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154712 · Cited by 418 · see citing works
Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer
Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works
Diet and the human gut microbiome: An international review
Wilson, A. S., Koller, K. R., Ramaboli, M. C., Nesengani, L. T., Ocvirk, S., Chen, C., Flanagan, C. A., Sapp, F. R., Merritt, Z. T., Bhatti, F., et al. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06112-w · Cited by 369 · see citing works
Self-citationInteractions between probiotics and pathogenic microorganisms in hosts and foods: A review
Mousavi Khaneghah, A., Abhari, K., Eş, I., Soares, M. B., Oliveira, R. B. A., Hosseini, H., Rezaei, M., Balthazar, C. F., Silva, R., Cruz, A. G., et al. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.11.022 · Cited by 275 · see citing works
Kong, C., Liang, L., Liu, G., Du, L., Yang, Y., Liu, J., Shi, D., Li, X., & Ma, Y. (2023) · Gut · doi:10.1136/gutjnl-2022-327156 · Cited by 254 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Dysbiosis of the Gut Microbiome Is Associated With Tumor Biomarkers in Lung Cancer
Liu, F., Li, J., Guan, Y., Lou, Y., Chen, H., Xu, M., Deng, D., Chen, J., Ni, B., Zhao, L., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.35980 · Cited by 197 · see citing works
Oliver, A., Chase, A. B., Weihe, C., Orchanian, S. B., Riedel, S. F., Hendrickson, C. L., Lay, M., Sewall, J. M., Martiny, J. B. H., & Whiteson, K. (2021) · mSystems · doi:10.1128/msystems.00115-21 · Cited by 171 · see citing works
Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer
Zheng, X., Hur, J., Nguyen, L. H., Liu, J., Song, M., Wu, K., Smith-Warner, S. A., Ogino, S., Willett, W. C., Chan, A. T., et al. (2021) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djaa164 · Cited by 136 · see citing works
Food Design To Feed the Human Gut Microbiota
Ercolini, D., & Fogliano, V. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00456 · Cited by 146 · see citing works
Carcinogenesis and therapeutics: the microbiota perspective
Tsilimigras, M. C. B., Fodor, A., & Jobin, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.8 · Cited by 144 · see citing works
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice
Mendes, M. C. S., Paulino, D. S., Brambilla, S. R., Camargo, J. A., Persinoti, G. F., & Carvalheira, J. B. C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i18.1995 · Cited by 116 · see citing works
Rise of PD-L1 expression during metastasis of colorectal cancer: Implications for immunotherapy
Wang, H. B., Yao, H., Li, C. S., Liang, L. X., Zhang, Y., Chen, Y. X., Fang, J., & Xu, J. (2017) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12538 · Cited by 100 · see citing works
Alvandi, E., Wong, W. K. M., Joglekar, M. V., Spring, K. J., & Hardikar, A. A. (2022) · BMC Medicine · doi:10.1186/s12916-022-02529-4 · Cited by 101 · see citing works
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding
Jans, M., Kolata, M., Blancke, G., D’Hondt, A., Gräf, C., Ciers, M., Sze, M., Thiran, A., Petta, I., Andries, V., et al. (2024) · Nature · doi:10.1038/s41586-024-08135-z · Cited by 84 · see citing works
The microbiota: An underestimated actor in radiation-induced lesions?
Sokol, H., & Adolph, T. E. (2018) · Gut · doi:10.1136/gutjnl-2017-314279 · Cited by 52 · see citing works
Cai, J.-A., Zhang, Y.-Z., Yu, E.-D., Ding, W.-Q., Jiang, Q.-W., Cai, Q.-C., & Zhong, L. (2023) · Nutrients · doi:10.3390/nu15132940 · Cited by 9 · see citing works
Di Pierro, F., Sagheddu, V., Galletti, S., Casaroli, A., Labrini, E., Soldi, S., Cazzaniga, M., Bertuccioli, A., Matera, M., Cavecchia, I., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10522-5 · Cited by 5 · see citing works
- Authors
- O'Keefe, S. J. D.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2016-11-16
- Volume
- 13
- Issue
- 12
- Pages
- 691-706
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- PMC
- PMC6312102
- OpenAlex
- W2551647589
- Cited by
- 1,100
- References
- 186
- Citations by year
- 2026: 89 · 2025: 118 · 2024: 112 · 2023: 145 · 2022: 140 · 2021: 164 · 2020: 117 · 2019: 95 · 2018: 74 · 2017: 45
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA135379, R01CA204403)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- colorectal cancer, gut microbiota, microbial metabolites, diet, short-chain fatty acids, butyrate, dietary fiber, meat consumption, bile acids, colonic fermentation, inflammation, carcinogenesis, mucosal integrity, cancer prevention
- MeSH terms
- Diet, Healthy, Butyrates, Colonic Neoplasms, Diet, Dietary Fats, Dietary Fiber, Humans, Obesity, Risk Factors, Global Health, Phytochemicals, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review