The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment
Abstract
Gut microbiota constitute the largest reservoir of the human microbiome and are an abundant and stable ecosystem—based on its diversity, complexity, redundancy, and host interactions This ecosystem is indispensable for human development and health. The integrity of the intestinal mucosal barrier depends on its interactions with gut microbiota. The commensal bacterial community is implicated in the pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC). The dysbiosis of microbes is characterized by reduced biodiversity, abnormal composition of gut microbiota, altered spatial distribution, as well as interactions among microbiota, between different strains of microbiota, and with the host. The defects in microecology, with the related metabolic pathways and molecular mechanisms, play a critical role in the innate immunity of the intestinal mucosa in UC. Fecal microbiota transplantation (FMT) has been used to treat many diseases related to gut microbiota, with the most promising outcome reported in antibiotic‐associated diarrhea, followed by IBD. This review evaluated the results of various reports of FMT in UC. The efficacy of FMT remains highly controversial, and needs to be regularized by integrated management, standardization of procedures, and individualization of treatment.
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Cites
Diet rapidly and reproducibly alters the human gut microbiome
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BackgroundMulti-omics of the gut microbial ecosystem in inflammatory bowel diseases
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“and Escherichia coli) play a crucial role in maintaining the network function and homeostasis.(14,65)”
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Cited by
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments
Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63
Metadata
- Authors
- Guo, X. Y., Liu, X. J., & Hao, J. Y.
- Venue
- Journal of Digestive Diseases
- Publisher
- Wiley
- Published
- 2020-03
- Volume
- 21
- Issue
- 3
- Pages
- 147-159
- ISSN
- 1751-2972 (ISSN-L)
- 1751-2980
- OpenAlex
- W3006550824
- Cited by
- 336
- References
- 157
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guo, X. Y., Liu, X. J., & Hao, J. Y. (2020). Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment. Journal of Digestive Diseases. https://doi.org/10.1111/1751-2980.12849
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
