Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Arriola Apelo, Sebastian I., Neuman, Joshua C., Baar, Emma L., Syed, Faizan A., Cummings, Nicole E., Brar, Harpreet K., Pumper, Cassidy P., Kimple, Michelle E., Lamming, Dudley W.·2016·Aging Cell

DOI 10.1111/acel.12405

Cited by (181)

Items 101–181 of 181

Dynamic modeling of signal transduction by mTOR complexes in cancer
Mohammadreza Dorvash, Mohammad Farahmandnia, Pouria Mosaddeghi, Mitra Farahmandnejad, Hosein Saber, Mohammadhossein Khorraminejad‐Shirazi, Amir Azadi, Iman Tavassoly · 2019 · Journal of Theoretical Biology
Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model
Kaitrin Kramer, Jingwen Yang, W. Benton Swanson, Satoru Hayano, Masako Toda, Haichun Pan, Jin Koo Kim, Paul H. Krebsbach, Yuji M. Mishina · 2018 · genesis
Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan
Francesca Matteini, Sara Montserrat‐Vazquez, Maria Carolina Florian · 2024 · FEBS Letters
Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin
Christian J. Elliehausen, Dennis M. Minton, Alexander D. Nichol, Adam R. Konopka · 2021 · Experimental Gerontology
Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats
Andrea Di Francesco, Alberto Díaz‐Ruiz, Rafael de Cabo, Michel Bernier · 2018 · The Journals of Gerontology Series A
Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury
Qingyu Stephanie Zhou, Justin Doherty, Antonina M. Akk, Luke E. Springer, Ping Fan, Ivan Spasojević, Ganesh V. Halade, Huanghe Yang, Christine T. N. Pham, Samuel A. Wickline et al. · 2022 · Nanomaterials
Rapamycin impairs bone accrual in young adult mice independent of Nrf2
Stephen A. Martin, Ruben Riordan, Rong Wang, Zhentao Yu, Allan M. Aguirre-Burk, Carmen P. Wong, Dawn A. Olson, Adam J. Branscum, Russell T. Turner, Urszula T. Iwaniec et al. · 2021 · Experimental Gerontology
Rapamycin increases the incidence of neuropsychiatric illness in kidney transplant patients through the suppression of neural stem cells
Yangsik Kim, Jung Sun Lee, Yeon Ho Joo · 2020 · Translational Psychiatry
Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study
Victor N. Rivas, Joanna L. Kaplan, Susan A. Kennedy, Stuart Fitzgerald, Amanda E. Crofton, Aisling Farrell, Louise Grubb, Carina E. Jauregui, Gabriela Grigorean, Eunju April Choi et al. · 2023 · Animals
Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies
Joseph Kofi Abankwah, Ying Wang, Jida Wang, Ogbe Susan Enechojo, Lisa Dal Pozzo, XiaoQian Chu, Yuhong Bian · 2024 · Heliyon
Pharmacologic inhibition of mTORC1 mimics dietary protein restriction in a mouse model of lactation
Virginia L. Pszczolkowski, Steven J. Halderson, Emma J. Meyer, Amy Lin, Sebastian I. Arriola Apelo · 2020 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
The effects of macronutrients metabolism on cellular and organismal aging
Jamil Nehme, Abdullah Altulea, Teodora Gheorghe, Marco Demaria · 2023 · Biomedical Journal
mTOR inhibitors for treatment of low-risk prostate cancer
Michael Andre Liss, Lanette Rickborn, John DiGiovanni, Dean J. Bacich, Linda A. deGraffenried, Manish Parihar, Ian Murchie Thompson, Zelton Dave Sharp · 2018 · Medical Hypotheses
The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
Phillip E. MacCallum, Jacqueline J. Blundell · 2020 · Psychopharmacology
Nutrition and energetics in rodent longevity research
Victoria K. Gibbs, Daniel L. Smith · 2016 · Experimental Gerontology
Effects of combined treatment with blood flow restriction and low-current electrical stimulation on muscle hypertrophy in rats
Madoka Yoshikawa, Takeshi Morifuji, Tomohiro Matsumoto, Noriaki Maeshige, Minoru Tanaka, Hidemi Fujino · 2019 · Journal of Applied Physiology
Superior cancer preventive efficacy of low versus high dose of mTOR inhibitor in a mouse model of prostate cancer
Marina P. Antoch, Michelle M. Wrobel, Bryan M. Gillard, Karen K. Kuropatwinski, Ilia A. Toshkov, Anatoli S. Gleiberman, Ellen Karasik, Michael T. Moser, Barbara A. Foster, Ekaterina L. Andrianova et al. · 2020 · Oncotarget
Common targets for a deadly duo of diabetes mellitus and colon cancer: Catching two fish with one worm
Saumitra Gajjar, Bhoomika M. Patel · 2020 · European Journal of Pharmacology
Clinical impact and economic burden of post-transplant infections following heart transplantation: A retrospective nationwide cohort study
Suk‐Chan Jang, Byeong-Chan Oh, Jin Hyun Nam, Eui‐Kyung Lee, Hye‐Lin Kim, Sun‐Hong Kwon · 2022 · The Journal of Heart and Lung Transplantation
Effects of low-dose rapamycin on lymphoid organs of mice prone and resistant to accelerated senescence
Rafael dos Santos Barros, Luiz A. D. Queiroz, Josiane Betim de Assis, Kamilla Costa Pantoja, Sofia Xavier Bustia, Emanuella Sarmento Alho de Sousa, Stephen Fernandes Rodrigues, Eliana Hiromi Akamine, Anderson Sá‐Nunes, Joilson Oliveira Martins · 2024 · Frontiers in Immunology
Restored autophagy is protective against PAK3-induced cardiac dysfunction
Andrea Ruiz‐Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser hawimel o Alatawi, Jessica M. Miller, Riham Abouleisa, Qinghui Ou, Xiangjun Zhao et al. · 2023 · iScience
Hungering for Immortality.
Joel C. Eissenberg · 2018 · Europe PMC (PubMed Central)
Rapamycin does not alter bone microarchitecture or material properties quality in young-adult and aged female C57BL/6 mice
Connor Devine, Kenna C Brown, Kat O Paton, Chelsea M. Heveran, Stephen A Martin · 2024 · JBMR Plus
Peripheral tissular analysis of rapamycin’s effect as a neuroprotective agent in vivo
Alfredo González-Alcocer, Yareth Gopar‐Cuevas, Adolfo Soto‐Domínguez, María de Jesús Loera‐Arias, Odila Saucedo Cárdenas, Roberto Montes‐de‐Oca‐Luna, Humberto Rodríguez‐Rocha, Aracely García‐García · 2022 · Naunyn-Schmiedeberg s Archives of Pharmacology
Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR
Cihan Süleyman Erdogan, Benni Winding Hansen, Ole Vang · 2016 · Mechanisms of Ageing and Development
Silk fibroin/dual drugs eluting polydioxanone monofilament braided ureteral stent with antibacterial and anti-stenotic functions
Lirong Duan, Jing Wang, Zhijun Miao, Dulin Zuo, Weiwei Sun, Lu Li, Fanlei Yang, Chao Deng, Feng Li, Gang Shen et al. · 2025 · International Journal of Biological Macromolecules
Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice
Christian J. Elliehausen, Szczepan S. Olszewski, Carolyn G. Shult, Aditya R. Ailiani, Michaela E. Trautman, Reji Babygirija, Dudley W. Lamming, Troy Alan Hornberger, Dennis M. Minton, Adam R. Konopka · 2025 · Aging Cell
Semisynthesis of 3‐Hydroxyoxindole Rapamycin Analogues Through Site‐ and Stereoselective Trapping of Oxonium Ylides in RhII‐Catalyzed Three‐Component Reactions
Lin Qiu, Meng Su, Zhongqing Wen, Xiangcheng Zhu, Yanwen Duan, Yong Ping Huang · 2019 · European Journal of Organic Chemistry
Geroprotectors and Skeletal Health: Beyond the Headlines
Alexandra Rayson, Maya Boudiffa, Maneeha Naveed, Jon Griffin, Enrico Dall’Ara, Ilaria Bellantuono · 2022 · Frontiers in Cell and Developmental Biology
Pyrans and Benzo Derivatives: Applications
Dainis Kaldre · 2020 · Elsevier eBooks
Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice
Luiz A. D. Queiroz, Rafael Santos de Barros, Josiane Betim de Assis, Camille Cristine Caldeira Silva, Walter Miguel Turato, Sofia Xavier Bustia, Stephen Fernandes Rodrigues, Anderson Sá‐Nunes, Joilson Oliveira Martins · 2025 · Frontiers in Immunology
Effects of Rapamycin on Insulin Brain Endothelial Cell Binding and Blood–Brain Barrier Transport
Steven Nguyen, William A. Banks, Elizabeth M. Rhea · 2021 · Medical Sciences
The Role of S6K1 in Aging and Alzheimer’s Disease: Mechanistic Insights and Therapeutic Potential
Salvatore Oddo, Marika Lanza, Giovanna Casili, Antonella Caccamo · 2025 · International Journal of Molecular Sciences
A novel rapalog shows improved safety vs. efficacy in a human organoid model of polycystic kidney disease
Ramila E. Gulieva, Parvaneh Ahmadvand, Benjamin Freedman · 2025 · Stem Cell Reports
Innovations in Vascular Repair from Mechanical Intervention to Regenerative Therapies
Hye-min Park, Chae-lin Kim, Dasom Kong, Seon-Hee Heo, Hyun‐Ji Park · 2025 · Tissue Engineering and Regenerative Medicine
Insulin Resistance, Secretion and Clearance –Taming the Three Effector Encounter of Type 2 Diabetes
Jacob Bar‐Tana · 2021 · Frontiers in Endocrinology
Chronic rapamycin pretreatment modulates arginase/inducible nitric oxide synthase balance attenuating aging-dependent susceptibility to Trypanosoma cruzi infection and acute myocarditis
Margarida P. Santos, Elda Gonçalves-Santos, Matheus Augusto Souza, Ivo Santana Caldas, Graziela Domingues de Almeida Lima, Reggiani Vilela Gonçalves, Rômulo Dias Novaes · 2021 · Experimental Gerontology
Neuroprotection of Everolimus Against Focal Cerebral Ischemia-Reperfusion Injury in Rats
Fatemeh Forouzanfar, Payam Razavi Ebrahimi, Hamid Reza Sadeghnia · 2022 · Journal of Stroke and Cerebrovascular Diseases
Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
Andrzej Gałat · 2017 · Biomolecules
Is rapamycin a rapalog?
David J. Glass, Dudley W. Lamming · 2018 · Nutrition and Healthy Aging
Individual dietary amino acid restrictions induce distinct metabolic and chromatin states
Spencer A. Haws, Yang Liu, Cara L. Green, Krittisak Chaiyakul, Pragyan Mishra, Reji Babygirija, Eric A. Armstrong, Anusha T. Mehendale, Irene M. Ong, Dudley W. Lamming et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
The rationale for testing drug combinations in aging intervention studies
Sharma, Kavita, Wang, Juan, Jiang, Zhou, Klug, Jenna, Darvas, Martin, M. Imai, Denise, Snider, Timothy, Niedernhofer, Laura, Ladiges, Warren · 2019 · Aging Pathobiology and Therapeutics
Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin
David A. Barzilai · 2025 · Aging
The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
Shima Shirzad, Farzaneh Vafaee, Fatemeh Forouzanfar · 2023 · Cellular and Molecular Neurobiology
Rapamycin and rapalogs
Dudley W. Lamming · 2023 · Elsevier eBooks
Commentary: Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia–Reperfusion With Increased Blood–Brain Barrier Disruption
Daniel J. Beard, Gina Hadley, Brad A. Sutherland, Alastair Mitchell Buchan · 2021 · Frontiers in Physiology
Interactions Among mTORC, AMPK and SIRT A Computational Model for Cell Energy Balance and Metabolism
Mehrshad Sadria, Anita T. Layton · 2020 · Research Square
mTOR signaling contributes to system-driven rhythmic gene expression in mouse liver
Aishwarya Sahasrabudhe, Chanté R. Guy, Audrey Jacq, Chieh-Wen Ho, Ben J. Greenwell, Jérôme S. Menet · 2026 · Science Advances
Nutrient regulation of inflammatory signalling in obesity and vascular disease
Timothy M. Palmer, Ian P. Salt · 2021 · Clinical Science
CD73-expressing endometrial regenerative cell-derived exosomes mitigate acute cardiac allograft rejection through regulating adenosine metabolism in mice
Chenglu Sun, Dejun Kong, Hong Qin, Shilong Li, Conglin Wang, Shaohua Ren, Yini Xu, Hongda Wang, Hao Wang · 2025 · Stem Cell Research & Therapy
Impact of Rapamycin on Longevity: Updated Insights
Mehdi Sanati, Amir R. Afshari, Samaneh Aminyavari, Maciej Banach, Amirhossein Sahebkar · 2024 · Archives of Medical Science
Chemical Proteomics Reveals that the Anticancer Drug Everolimus Affects the Ubiquitin–Proteasome System
Anna A. Lobas, Amir Ata Saei, Hezheng Lyu, Roman A. Zubarev, Mikhail V. Gorshkov · 2024 · ACS Pharmacology & Translational Science
An mTOR inhibitor discovery system using drug-sensitized yeast
Andrew Breen, Sarah Ann Thomas, David Beckett, Matthew Agsalud, Graham Gingras, J. Andrew Williams, Brian M. Wasko · 2025 · GeroScience
Rapamycin’s Role in Periodontal Health and Therapeutics: A Scoping Review
Vinayak Joshi, S. B. Gururaj, Vivek Thumbigere‐Math, Manohar Suresh Kugaji, Eswar Kandaswamy · 2025 · JDR Clinical & Translational Research
Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice
Alia Saeed Albawardi, Dhanya Saraswathiamma, Charu Sharma, Abdulghani S. Elomami, Abdul‐Kader Souid, Saeeda Saleh Almarzooqi · 2023 · International Journal of Molecular Sciences
Atrial myocyte senescence as a driver of atrial fibrillation: mechanisms and therapeutic implications
Zhaoyang Wei, Zhixiong Li, Nanhu Quan · 2026 · Frontiers in Cell and Developmental Biology
Fasting-mimicking diets as a strategy to reprogram tumor metabolism: a systematic review
Irislene Costa Pereira, Jorddam Almondes Martins, Dallyla Jennifer Morais de Sousa, Maria Shelda de Oliveira Neres, RODRIGO SOARES PEREIRA LIMA, Jheniffer da Silva Sousa, Rebeca Lima Monteiro, Felipe Cavalcanti Carneiro da Silva, Juliana Soares Severo, Francisco Leonardo Torres‐Leal · 2026 · European Journal of Nutrition
Bench to bedside: is rapamycin headed for the docTOR?
Dudley W. Lamming · 2026 · GeroScience
An All-in-One Photothermal Nanocomposite Hydrogel for Controlling Inducible Transgene Expression
Rodrigo Serrano-Yamba, Clara Escudero-Duch, Cristina Yus, Marı́a Recuero, Daniel López, Laura Saldaña, Manuel Arruebo, Nuria E. Vilaboa · 2026 · ACS Applied Materials & Interfaces
Rapamycin did not prevent the excessive exercise-induced hepatic fat accumulation
Ana P. Pinto, Alisson Luiz da Rocha, Giovana Rampazzo Teixeira, Rafael L. Rovina, Allice Santos Cruz Veras, Fabiani Gai Frantz, José Rodrigo Pauli, Leandro Pereira de Moura, Dennys E. Cintra, Eduardo Rochete Ropelle et al. · 2022 · Life Sciences
Sirolimus treatment induces dose-dependent involution of the thymus with elevated cellular respiration in BALB/c mice.
Saeeda Saleh Almarzooqi, Charu Sharma, Dhanya Saraswathiamma, Ahmed R. Alsuwaidi, Noura Hadid, Abdul‐Kader Souid, Alia Saeed Albawardi · 2022 · PubMed Central
Rapamycin does not compromise physical performance or muscle hypertrophy after PoWeR while intermittent rapamycin alleviates glucose disruptions by frequent rapamycin
Christian J. Elliehausen, Szczepan S. Olszewski, Carolyn G. Shult, Aditya R. Ailiani, Michaela E. Trautman, Reji Babygirija, Dudley W. Lamming, Troy Alan Hornberger, Dennis M. Minton, Adam R. Konopka · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Paradigmenwechsel in der Anti-Aging- Medizin: Hormesis, Target-of-Rapamycin-Komplex und erste Anti-Aging-Pillen
Alexander Römmler · 2016 · Journal für Kardiologie (Krause & Pachernegg GmbH)
Paradigmenwechsel in der Anti-Aging- Medizin: Hormesis, Target-of-Rapamycin-Komplex und erste Anti-Aging-Pillen
Alexander Römmler · 2016
Bone Marrow-Derived Stem Cells as a Cytotherapy for Sirolimus-Induced Periodontal Ligament and Alveolar Bone Injury in a Rat Model
Rasha Mohamed Taha, Heba Elsaied · 2019 · Egyptian Dental Journal /Egyptian Dental Journal
The conductors of the metabolic orchestra
Tomas Koltai, Stephan J. Reshkin, Fátima Baltazar, Larry Fliegel · 2021 · Elsevier eBooks
Mecanismos moleculares relacionados ao aumento do conteúdo hepático de gordura em resposta ao excesso de exercício físico
Ana Paula Pinto · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
Faculty Opinions recommendation of mTOR at the nexus of nutrition, growth, ageing and disease.
Shawn M. Ferguson · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Disrupted cellular quality control mechanisms in aging
Cristina Carvalho, Joana F. Pires, Paula Isabel Moreira, Nuno Raimundo · 2022 · Elsevier eBooks
Combination of Volasertib and Rapamycin Inhibits the Regrowth of TSC2-Deficient Tumors
Matthildi Valianou, Erik Y. Zhang, Daniel L. Johnson, Rhett Meyers, Maciej M. Markiewski, Magdalena Karbowniczek, Lawrence M. Pfeffer, Jane J. Yu, John J. Bissler, Aristotelis Astrinidis · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
O efeito do tratamento com rapamicina em órgãos linfoides de camundongos propensos à senescência acelerada
Rafael dos Santos Barros · 2023 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
An mTOR Inhibitor Discovery System Using the Growth of Drug-Sensitized Yeast Strains
Anna K. Breen, Sarah Ann Thomas, David Beckett, Matthew Agsalud, Graham Gingras, J. Andrew Williams, Brian M. Wasko · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Electrical alternans of the Q-T interval and fatal arrhythmias caused by neonatal cardiac tumor: a case report
Ge Wang, Jin Ding, Hongmei Wu, Yanhong Chen, Xiaoqi Deng, Hairui Li, Haiying Li · 2025 · Frontiers in Cardiovascular Medicine
Additional file 3 of Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism
Mehrshad Sadria, Layton, Anita T. · 2021 · Figshare
Abstract 052 | What is the impact of late-life rapamycin on exercise adaptations in older mice?
Adam R. Konopka · 2026 · European Journal of Translational Myology
Revisiting old drugs and drug combinations for polycythemia vera and related neoplasms
Gökhan Mergen, Hans Carl Hasselbalch · 2026 · Frontiers in Hematology
Phase II Trial of Encapsulated Rapamycin to Reduce Polyp Burden Associated with Familial Adenomatous Polyposis
Joseph C Broderick, Niloy Jewel Samadder, Elena M. Stoffel, John C. Fang, Peter P. Stanich, Paul E. Wise, Randy P. Wright, Guy Travis Clifton, George Earl Peoples, Carol Ann Burke · 2026 · Clinical Cancer Research
From lifespan extension to hallmark-informed gerotherapeutic prioritization: A bibliometric-guided, strategy-oriented review of anti-aging drug research
Zhen Liu, Ainikaer Abulaiti, Deyu Li, Jiashun Li, Paerhati Wahafu, Yu Zhang, Maerdan Maimaitiming, S Y Li, Guohua Li, Maihemuti Yakufu · 2026 · Ageing Research Reviews
Mathematical and Computational Models of Biochemical Reactions and Cell Signaling—From Ordinary Differential Equations to Machine Learning
Grzegorz Matyszczak · 2026 · International Journal of Molecular Sciences
Molecular mechanisms of cellular senescence and targeted intervention with natural bioactive compounds
Silu Zhang, Shijing Ma, Hailong Li, Yuchen Pang, Yangyan Dai, Xiaomeng Liu, Tiantian Zhao, Bin Liu, Huixiong Chen · 2026 · Journal of Dermatologic Science and Cosmetic Technology
The polycentric aging framework: epigenetic regulation as a dominant lifespan-limiting center in human aging
Michał Bartoszewicz, Mariusz Niemczyk · 2026 · Aging