Lamming, Dudley W.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 3,796

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,199

Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 950

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Yilmaz, Ö. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., et al. (2012) · Nature

PI3K/AKT/mTOR signaling in cancerGenetics, Aging, and Longevity in Model Organisms

Cited by 753

Molecular mechanisms of dietary restriction promoting health and longevity

Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 714

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 648

The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism

PI3K/AKT/mTOR signaling in cancerGenetics, Aging, and Longevity in Model Organisms

Cited by 544

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 531

Decreased consumption of branched-chain amino acids improves metabolic health

Fontana, L., Cummings, N. E., Arriola Apelo, S. I., Neuman, J. C., Kasza, I., Schmidt, B. A., Cava, E., Spelta, F., Tosti, V., Syed, F. A., et al. (2016) · Cell Reports

Diet, Metabolism, and DiseaseDietary Effects on Health

Cited by 466

Targeting the biology of aging with mTOR inhibitors

Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 372

Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., et al. (2016) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 362

Calorie restriction in humans inhibits the PI 3 K/AKT pathway and induces a younger transcription profile

Mercken, E. M., Crosby, S. D., Lamming, D. W., JeBailey, L., Krzysik‐Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., et al. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Cited by 261

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Arriola Apelo, S. I., Neuman, J. C., Baar, E. L., Syed, F. A., Cummings, N. E., Brar, H. K., Pumper, C. P., Kimple, M. E., & Lamming, D. W. (2016) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 182

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 171

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

Lamming, D. W., Cummings, N. E., Rastelli, A. L., Gao, F., Cava, E., Bertozzi, B., Spelta, F., Pili, R., & Fontana, L. (2015) · Oncotarget

PI3K/AKT/mTOR signaling in cancerDietary Effects on Health

Cited by 69

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

Liu, Y., Diaz, V., Fernandez, E., Strong, R., Ye, L., Baur, J. A., Lamming, D. W., Richardson, A., & Salmon, A. B. (2014) · Aging

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 68

Resistance exercise protects mice from protein-induced fat accretion

Trautman, M. E., Braucher, L. N., Elliehausen, C., Zhu, W. G., Zelenovskiy, E., Green, M., Sonsalla, M. M., Yeh, C.-Y., Hornberger, T. A., Konopka, A. R., et al. (2023) · eLife

Muscle metabolism and nutritionMuscle Physiology and Disorders

Cited by 8

Resistance exercise protects mice from protein-induced fat accretion

Trautman, M. E., Braucher, L. N., Elliehausen, C., Zhu, W. G., Zelenovskiy, E., Green, M., Sonsalla, M. M., Yeh, C.-Y., Hornberger, T. A., Konopka, A. R., et al. (2023) · eLife

Muscle metabolism and nutritionMuscle Physiology and Disorders

Cited by 1

Resistance exercise protects mice from protein-induced fat accretion

Trautman, M. E., Braucher, L. N., Elliehausen, C., Zhu, W. G., Zelenovskiy, E., Green, M., Sonsalla, M. M., Yeh, C.-Y., Hornberger, T. A., Konopka, A. R., et al. (2023) · eLife

Muscle metabolism and nutritionMuscle Physiology and Disorders

Cited by 0

Resistance exercise protects mice from protein-induced fat accretion

Trautman, M. E., Braucher, L. N., Elliehausen, C., Zhu, W. G., Zelenovskiy, E., Green, M., Sonsalla, M. M., Yeh, C.-Y., Hornberger, T. A., Konopka, A. R., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Muscle metabolism and nutritionMuscle Physiology and Disorders

Cited by 0