The DrugAge Database of Aging-Related Drugs
Open accessAbstract
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
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Enrichment analysis on the DrugAge database showed that GSH is among the most common targets of lifespan-prolonging drugs.
“Indeed, enrichment analysis research performed on the DrugAge database, a repository of compounds known to extend life, showed that GSH is among the most common targets of lifespan prolonging drugs [196].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [196]
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A multidimensional systems biology analysis of cellular senescence in aging and disease
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- Authors
- Barardo, D., Thornton, D., Thoppil, H., Walsh, M., Sharifi, S., Ferreira, S., Anžič, A., Fernandes, M., Monteiro, P., Grum, T., Cordeiro, R., De-Souza, E. A., Budovsky, A., Araujo, N., Gruber, J., Petrascheck, M., Fraifeld, V. E., Zhavoronkov, A., Moskalev, A., & de Magalhães, J. P.
- Affiliations
- University of Liverpool (GB)
- ETH Zurich (CH)
- Department of Biophysics; Federal University of São Paulo; São Paulo Brazil
- Ben-Gurion University of the Negev (IL)
- National University of Singapore (SG)
- Scripps Research Institute (US)
- Pharmaceutical Artificial Intelligence Research Division; Emerging Technology Centers; Insilico Medicine, Inc; Johns Hopkins University at Eastern; B301, 1101 33rd Street Baltimore MD 21218 USA
- Engelhardt Institute of Molecular Biology (RU)
- Integrative Genomics of Ageing Group; Institute of Ageing and Chronic Disease; University of Liverpool; Liverpool UK
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2017-03-16
- Volume
- 16
- Issue
- 3
- Pages
- 594-597
- ISSN
- 1474-9718 (ISSN-L)
- PMC
- PMC5418190
- OpenAlex
- W2595793016
- Cited by
- 173
- References
- 6
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 21 · 2023: 24 · 2022: 18 · 2021: 21 · 2020: 13 · 2019: 13 · 2018: 15 · 2017: 5 · 2015: 1
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Aging Cell (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection (cc-by)
- Funders
- Wellcome Trust (104978/Z/14/Z)
- Israel Ministry of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, model organisms, drug-gene interactions, therapeutic target, functional enrichment, glutathione, antioxidant activity, ion transport, metabolism, aging-related genes, longevity
- MeSH terms
- Aging, Animals, Antioxidants, Drosophila melanogaster, Geriatrics, Humans, Saccharomyces cerevisiae, User-Computer Interface, Caenorhabditis elegans, Computational Biology, Membrane Transport Modulators, Mice, Metabolic Networks and Pathways, Databases, Pharmaceutical
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