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Cited by 60Prenatal Substance Exposure EffectsNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment

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Vetreno, Ryan P., Yaxley, Richard, Paniagua, Beatriz, Johnson, G. Allan, Crews, Fulton T.·2017·Addiction Biology
DOI 10.1111/adb.12364PMC PMC4969224
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Abstract

Human studies have established that adolescence is a period of brain maturation that parallels the development of adult behaviors. However, little is known regarding cortical development in the adult rat brain. We used magnetic resonance imaging (MRI) and histology to assess the impact of age on adult Wistar rat cortical thickness on postnatal day (P)80 and P220 as well as the effect of adolescent binge ethanol exposure on adult (P80) cortical thickness. MRI revealed changes in cortical thickness between P80 and P220 that differ across cortical region. The adult P220 rat prefrontal cortex increased in thickness whereas cortical thinning occurred in both the cingulate and parietal cortices relative to young adult P80 rats. Histological analysis confirmed the age‐related cortical thinning. In the second series of experiments, an animal model of adolescent intermittent ethanol (AIE; 5.0 g/kg, intragastrically, 20 percent ethanol w/v, 2 days on/2 days off from P25 to P55) was used to assess the effects of alcohol on cortical thickness in young adult (P80) rats. MRI revealed that AIE resulted in region‐specific cortical changes. A small region within the prefrontal cortex was significantly thinner whereas medial cortical regions were significantly thicker in young adult (P80) AIE‐treated rats. The observed increase in cortical thickness was confirmed by histology. Thus, the rat cerebral cortex continues to undergo cortical thickness changes into adulthood, and adolescent alcohol exposure alters the young adult cortex that could contribute to brain dysfunction in adulthood.

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  • Increased thickness in the anterior cingulate and increased volume of the orbital FC have been observed in adult rodents exposed to alcohol during adolescence.

    “Conversely, increased thickness in the anterior cingulate and increased volume of the orbital FC has also been observed in adult rodents exposed to alcohol during adolescence (Coleman et al. 2014; Vetreno et al. 2017).”

    From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Vetreno et al. 2017

    The Discussion reports reduced thickness in the anterior cingulate cortex after adolescent intermittent ethanol exposure, not the claimed increase. It locates the increase in the posterior cingulate and retrosplenial cortices; the passages do not report increased orbital frontal cortex volume. (LLM, conf=0.90)

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  • Rodent models suggest that alterations in FC morphology following adolescent exposure to alcohol may be persistent, as rats exposed to chronic intermittent alcohol during adolescence had a bilateral reduction in prefrontal cortex thickness and basal forebrain volume as adults.

    “Rodent models suggest that alterations in FC morphology following adolescent exposure to alcohol may be persistent, as rats exposed to chronic intermittent alcohol exposure during the adolescent period had a bilateral reduction in prefrontal cortex thickness and basal forebrain volume as adults (Coleman et al. 2011; Vetreno et al. 2017).”

    From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Vetreno et al. 2017

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Cited by

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Authors
Vetreno, R. P., Yaxley, R., Paniagua, B., Johnson, G. A., & Crews, F. T.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Duke Medical Center (US)
Corresponding author
Vetreno, Ryan P.
ORCID
Venue
Addiction Biology
Publisher
Wiley
Published
2016-02
Volume
22
Issue
3
Pages
712-723
ISSN
  • 1355-6215 (ISSN-L)
  • 1369-1600
DOI
10.1111/adb.12364
PMC
PMC4969224
OpenAlex
W2322340227
Cited by
60
References
6
Citations by year
2026: 1 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 15 · 2018: 7 · 2017: 8 · 2016: 3
FWCI
12.80
Type
journal article
Language
en
Open access
Licence
Locations
  • Addiction Biology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (AA019767, AA11605, AA007573, AA021040)
  • National Institute on Alcohol Abuse and Alcoholism (AA020023, AA020024, AA020022)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
cortical thickness, adolescent intermittent ethanol exposure, binge ethanol, brain maturation, adult rat brain, prefrontal cortex, cingulate cortex, parietal cortex, cortical thinning, adolescent alcohol exposure
MeSH terms
Age Factors, Ethanol, Animals, Cerebral Cortex, Disease Models, Animal, Magnetic Resonance Imaging, Male, Rats, Sprague-Dawley, Rats, Binge Drinking

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