Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and toll-like receptors in the adult prefrontal cortex
Open accessAbstract
Adolescence is a critical developmental stage of life during which the prefrontal cortex (PFC) matures, and binge drinking and alcohol abuse are common. Recent studies have found that ethanol increases neuroinflammation via upregulated high-mobility group box 1 (HMGB1) signaling through Toll-like receptors (TLRs). HMGB1/TLR 'danger signaling' induces multiple brain innate immune genes that could alter brain function. To determine whether adolescent binge drinking persistently increases innate immune gene expression in the PFC, rats (P25-P55) were exposed to adolescent intermittent ethanol (AIE [5.0 g/kg, 2-day on/2-day off schedule]). On P56, HMGB1/TLR danger signaling was assessed using immunohistochemistry (i.e., +immunoreactivity [+IR]). In a separate group of subjects, spatial and reversal learning on the Barnes maze was assessed in early adulthood (P64-P75), and HMGB1/TLR danger signaling was measured using immunohistochemistry for +IR and RT-PCR for mRNA in adulthood (P80). Immunohistochemical assessment at P56 and 24 days later at P80 revealed increased frontal cortical HMGB1, TLR4, and TLR3 in the AIE-treated rats. Adolescent intermittent ethanol treatment did not alter adult spatial learning on the Barnes maze, but did cause reversal learning deficits and increased perseverative behavior. Barnes maze deficits correlated with the expression of danger signal receptors in the PFC. Taken together, these findings provide evidence that adolescent binge drinking leads to persistent upregulation of innate immune danger signaling in the adult PFC that correlates with adult neurocognitive dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous adolescent ethanol exposure did not impact acquisition of the Barnes maze but did disrupt reversal learning in adulthood, with alcohol exposed mice exhibiting longer latencies to find the new escape hole and spending a longer time in the previously learned hole location when compared to controls.
“They found that previous adolescent ethanol exposure did not impact acquisition of the Barnes maze but did disrupt reversal learning in adulthood, with alcohol exposed mice exhibiting longer latencies to find the new escape hole and spending a longer time in the previously learned hole location when compared to controls.”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Vetreno and Crews 2012
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredCertain aspects of HC-dependent learning and memory, such as spatial learning and memory, were not impacted following adolescent alcohol exposure but were in adults.
“Although there is evidence for persistent neurological and cognitive deficits in HC function, it is important to note that certain aspects of HC-dependent learning and memory, such as spatial learning and memory, were not impacted following adolescent exposure (Coleman et al. 2011; Vetreno and Crews 2012) but were in adults (Cippitelli et al. 2010).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Vetreno and Crews 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Monitoring the Future: National Results on Adolescent Drug Use: Overview of Key Findings
Johnston, L. D., O’Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2003) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1037/e560352009-001 · Cited by 6,930 · see citing works
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Self-citationPark, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works
HMGB1 and RAGE in Inflammation and Cancer
Sims, G. P., Rowe, D. C., Rietdijk, S. T., Herbst, R., & Coyle, A. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132603 · Cited by 1,436 · see citing works
Correlates of college student binge drinking.
Wechsler, H., Dowdall, G. W., Davenport, A. E., & Castillo, S. (1995) · American Journal of Public Health · doi:10.2105/ajph.85.7.921 · Cited by 787 · see citing works
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579 · see citing works
Neurocognitive Functioning of Adolescents: Effects of Protracted Alcohol Use
Brown, S. A., Tapert, S. F., Granholm, E. L., & Delis, D. C. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04586.x · Cited by 575 · see citing works
Qin, L., He, J., Hanes, R. N., Pluzarev, O., Hong, J.-S., & Crews, F. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-10 · Cited by 532 · see citing works
Self-citationIncreased MCP-1 and microglia in various regions of the human alcoholic brain
He, J., & Crews, F. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.11.017 · Cited by 516 · see citing works
Self-citationCrews, F. T., Braun, C. J., Hoplight, B., Switzer, R. C., & Knapp, D. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb01973.x · Cited by 504 · see citing works
Self-citationImmunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation
Garg, A. D., Nowis, D., Gołąb, J., Vandenabeele, P., Krysko, D. V., & Agostinis, P. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.003 · Cited by 498 · see citing works
Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
Hanke, M. L., & Kielian, T. (2011) · Clinical Science · doi:10.1042/cs20110164 · Cited by 493 · see citing works
Toll-Like Receptors in Neurodegeneration
Okun, E., Griffioen, K., Lathia, J., Tang, S.-C., Mattson, M., & Arumugam, T. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.001 · Cited by 459 · see citing works
Vezzani, A., Maroso, M., Balosso, S., Sanchez, M.-A., & Bartfai, T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.018 · Cited by 402 · see citing works
Pascual, M., Blanco, A. M., Cauli, O., Miñarro, J., & Guerri, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05298.x · Cited by 385 · see citing works
Critical role of TLR4 response in the activation of microglia induced by ethanol
Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373 · see citing works
MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365 · see citing works
Paull, T. T., Haykinson, M. J., & Johnson, R. C. (1993) · Genes & Development · doi:10.1101/gad.7.8.1521 · Cited by 332 · see citing works
Early drinking onset and its association with alcohol use and problem behavior in late adolescence
Gruber, E., DiClemente, R. J., Anderson, M. M., & Lodico, M. (1996) · Preventive Medicine · doi:10.1006/pmed.1996.0059 · Cited by 324 · cited 1× · see citing works
“In addition to the involvement of danger signal receptors in neuroinflammation, these receptors also modulate cognitive and emotive functioning (Dantzer et al., 2008; Okun et al., 2010; Hanke and Kielian, 2011; Yirmiya and Goshen, 2011).”
BackgroundThe Role of Orbitofrontal Cortex in Drug Addiction: A Review of Preclinical Studies
Schoenbaum, G. M., & Shaham, Y. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.003 · Cited by 314 · see citing works
Induction of innate immune genes in brain create the neurobiology of addiction
Crews, F. T., Zou, J., & Qin, L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.03.003 · Cited by 313 · see citing works
Self-citationNizri, E., Irony-Tur-Sinai, M., Lory, O., Orr‐Urtreger, A., Lavi, E., & Brenner, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902212 · Cited by 308 · see citing works
Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability
Riazi, K., Galic, M. A., & Pittman, Q. J. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.09.004 · Cited by 302 · see citing works
Crews, F. T., Qin, L., Sheedy, D. L., Vetreno, R. P., & Zou, J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.030 · Cited by 295 · see citing works
Self-citationQin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-5 · Cited by 290 · see citing works
Self-citationNeurogenesis in adolescent brain is potently inhibited by ethanol
Crews, F. T., Mdzinarishvili, A., Kim, D., He, J., & Nixon, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.090 · Cited by 265 · see citing works
Self-citationBlanco, A. M., Vallés, S. L., Pascual, M., & Guerri, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6893 · Cited by 258 · see citing works
Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats
Obernier, J., White, A. M., Swartzwelder, H. S., & Crews, F. T. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00715-3 · Cited by 257 · see citing works
Self-citationHMG1 and 2: architectural DNA-binding proteins
Thomas, J. O. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290395 · Cited by 254 · see citing works
Jurgens, H. A., Amancherla, K., & Johnson, R. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6389-11.2012 · Cited by 243 · see citing works
Hanson, K. L., Medina, K. L., Padula, C. B., Tapert, S. F., & Brown, S. A. (2011) · Journal of Child & Adolescent Substance Abuse · doi:10.1080/1067828x.2011.555272 · Cited by 235 · see citing works
Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis
Okun, E., Griffioen, K. J. S., Barak, B., Roberts, N. J., Castro, K., Pita, M. A., Cheng, A., Mughal, M. R., Wan, R., Ashery, U., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005807107 · Cited by 207 · see citing works
O’Malley, P. M., Johnston, L. D., & Bachman, J. G. (2000) · Choice Reviews Online · doi:10.5860/choice.37-3066 · Cited by 201 · see citing works
Coleman Jr, L. G., He, J., Lee, J., Styner, M., & Crews, F. T. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01385.x · Cited by 197 · see citing works
Self-citationHMGB1 in Development and Diseases of the Central Nervous System
Fang, P., Schachner, M., & Shen, Y.-Q. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8264-y · Cited by 193 · see citing works
BHT Blocks NF‐κB activation and Ethanol‐Induced Brain Damage
Crews, F. T., Nixon, K., Kim, D., Joseph, J. A., Shukitt‐Hale, B., Qin, L., & Zou, J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00239.x · Cited by 184 · see citing works
Self-citationWindle, M. T. (1999) · Sage eBooks · doi:10.4135/9781452233734 · Cited by 184 · see citing works
Regulation of cell migration by amphoterin
Fages, C., Nolo, R. M., Huttunen, H. J., Eskelinen, E., & Rauvala, H. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.4.611 · Cited by 166 · see citing works
Exercise reverses ethanol inhibition of neural stem cell proliferation
Crews, F. T., Nixon, K., & Wilkie, M. E. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.04.005 · Cited by 165 · see citing works
Self-citationZou, J., & Crews, F. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9045-9 · Cited by 164 · see citing works
Self-citationZou, J., & Crews, F. T. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01150.x · Cited by 158 · see citing works
Self-citationNeural substrates of cognitive inflexibility after chronic cocaine exposure
Stalnaker, T. A., Takahashi, Y. K., Roesch, M. R., & Schoenbaum, G. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.019 · Cited by 151 · see citing works
Comparative neuropsychology and Korsakoff's syndrome. I—Spatial and visual reversal learning
Oscar‐Berman, M., & Zola-Morgan, S. M. (1980) · Neuropsychologia · doi:10.1016/0028-3932(80)90152-9 · Cited by 137 · see citing works
Tapert, S. F., & Brown, S. A. (2000) · Addiction · doi:10.1046/j.1360-0443.2000.95710436.x · Cited by 135 · see citing works
Nizri, E., Irony-Tur-Sinai, M., Faranesh, N., Lavon, I., Lavi, E., Weinstock, M., & Brenner, T. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.018 · Cited by 129 · see citing works
Knapp, D. J., & Crews, F. T. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04165.x · Cited by 121 · see citing works
Self-citationTrudler, D., Farfara, D., & Frenkel, D. (2010) · Mediators of Inflammation · doi:10.1155/2010/497987 · Cited by 117 · see citing works
Rauvala, H., & Rouhiainen, A. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.012 · Cited by 109 · see citing works
White, H. R., Marmorstein, N. R., Crews, F. T., Bates, M. E., Mun, E.-Y., & Loeber, R. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01345.x · Cited by 92 · see citing works
Self-citationBadanich, K. A., Becker, H. C., & Woodward, J. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0025922 · Cited by 91 · see citing works
Ehlers, C. L., Criado, J. R., Wills, D. N., Liu, W., & Crews, F. T. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.011 · Cited by 79 · see citing works
Self-citationHigh mobility group box 1 (HMGB1)
Yang, H., & Tracey, K. J. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000187005.81616.a9 · Cited by 76 · see citing works
Spatial and visual learning deficits in Alzheimer's and Parkinson's disease
Freedman, M., & Oscar‐Berman, M. (1989) · Brain and Cognition · doi:10.1016/0278-2626(89)90009-2 · Cited by 69 · see citing works
High Mobility Group Box-1 (HMGB1; Amphoterin) Is Required for Zebrafish Brain Development
Zhao, X., Kuja‐Panula, J., Rouhiainen, A., Chen, Y., Panula, P., & Rauvala, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.223834 · Cited by 69 · see citing works
Cheng, G., Whitehead, S. N., Hachinski, V., & Cechetto, D. F. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.008 · Cited by 68 · see citing works
The Role of HMGB1/RAGE in Inflammatory Cardiomyopathy
Volz, H. C., Kaya, Z., Katus, H. A., & Andrassy, M. (2010) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0030-1251503 · Cited by 67 · see citing works
Targeting HMGB1 TLR4 signaling as a novel approach to treatment of cerebral ischemia
Yang, Q.-W. (2010) · Frontiers in Bioscience · doi:10.2741/s119 · Cited by 55 · see citing works
ATP‐P2X7receptor signaling controls basal and TNFα‐stimulated glial cell proliferation
Zou, J., Vetreno, R. P., & Crews, F. T. (2012) · Glia · doi:10.1002/glia.22302 · Cited by 53 · see citing works
Self-citationAnxiolytic potential of sulpiride, clozapine and derivatives in the open-field test
Bruhwyler, J., Chleide, E. M. G., Liégeois, J.-F., Delarge, J., & MERCIER, M. G. A. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90125-2 · Cited by 53 · see citing works
Delay discrimination and reversal eyeblink classical conditioning in abstinent chronic alcoholics.
Fortier, C. B., Steffen, E. M., Lafleche, G., Venne, J. R., Disterhoft, J. F., & McGlinchey, R. E. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.2.196 · Cited by 50 · see citing works
Kosaki, Y., & Watanabe, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.039 · Cited by 45 · see citing works
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Crews FT Qin L Sheedy D Vetreno RP Zou J HMGB1/ TLR receptor danger signaling increases brain neuroimmune activation in alcohol dependence Biol Psychiatry in press PMC3602398 23206318
- Johnston L O’Malley P Bachman J Schulenberg JE Monitoring the future: national survey results on drug use, 1975–2008 Secondary school students 2008 Vol. 1 Bethesda, MD National Institute on Drug Abuse Vol. xxxiv
Cited by
Sorted by citations
Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?
SPEAR, L. P. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.027 · Cited by 367 · see citing works
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Crews, F. T., Vetreno, R. P., Broadwater, M., & Robinson, D. L. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012138 · Cited by 332 · see citing works
Self-citationThe role of neuroimmune signaling in alcoholism
Crews, F. T., Lawrimore, C. J., Walter, T. J., & Coleman, L. G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.031 · Cited by 321 · see citing works
Self-citationMechanisms of neuroimmune gene induction in alcoholism
Crews, F. T., & Vetreno, R. P. (2016) · Psychopharmacology · doi:10.1007/s00213-015-3906-1 · Cited by 232 · see citing works
Self-citationNeuroimmune Function and the Consequences of Alcohol Exposure
Crews, F. T. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.15 · Cited by 200 · see citing works
Self-citationNeuroimmune signaling: a key component of alcohol abuse
Mayfield, J., Ferguson, L., & Harris, R. A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.024 · Cited by 193 · see citing works
Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System
Montesinos, J., Alfonso‐Loeches, S., & Guerri, C. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13208 · Cited by 184 · see citing works
Franklin, T., Wohleb, E. S., Zhang, Y., Fogaça, M. V., Hare, B. D., & Duman, R. S. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.034 · Cited by 173 · see citing works
Crews, F. T., Robinson, D. L., Chandler, L. J., Ehlers, C. L., Mulholland, P. J., Pandey, S. C., Rodd, Z. A., SPEAR, L. P., Swartzwelder, H. S., & Vetreno, R. P. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14154 · Cited by 166 · see citing works
Self-citationVetreno, R. P., & Crews, F. T. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00035 · Cited by 166 · see citing works
Self-citationKamal, H., Tan, G. C., Ibrahim, S. F., Shaikh, M. F., Mohamed, I. N., Mohamed, R. M. P., Hamid, A. A., Ugusman, A., & Kumar, J. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00282 · Cited by 164 · see citing works
Neuroimmune Basis of Alcoholic Brain Damage
Crews, F. T., & Vetreno, R. P. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00010-5 · Cited by 160 · see citing works
Self-citationToll-like receptor signaling and stages of addiction
Crews, F. T., Walter, T. J., Coleman, L. G., & Vetreno, R. P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4560-6 · Cited by 159 · see citing works
Self-citationImmunoadolescence: Neuroimmune development and adolescent behavior
Brenhouse, H. C., & Schwarz, J. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.035 · Cited by 153 · see citing works
Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases
García‐Bueno, B., Caso, J. R., Madrigal, J. L. M., & Leza, J. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.013 · Cited by 149 · see citing works
Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal
Walter, T. J., & Crews, F. T. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0856-z · Cited by 141 · see citing works
Self-citationThe long-term cognitive consequences of adolescent exposure to recreational drugs of abuse
Mooney-Leber, S. M., & Gould, T. J. (2018) · Learning & Memory · doi:10.1101/lm.046672.117 · Cited by 140 · see citing works
“Utilizing the Barnes maze, Vetreno and Crews (2012) assessed both spatial and reversal learning in adult rats that were exposed to chronic alcohol during the adolescent period.”
BackgroundMethodInfluentialVetreno, R. P., Qin, L., & Crews, F. T. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.07.002 · Cited by 132 · see citing works
Self-citationAntón, M., Alén, F., de Heras, R. G., Serrano, A., Pavón, F. J., Leza, J. C., García‐Bueno, B., de Fonseca, F. R., & Orío, L. (2016) · Addiction Biology · doi:10.1111/adb.12365 · Cited by 124 · see citing works
Pascual, M., Montesinos, J., Montagud‐Romero, S., Forteza, J., Rodríguez‐Arias, M., Miñarro, J., & Guerri, C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0918-2 · Cited by 119 · see citing works
Pascual, M., Pla, A., Miñarro, J., & Guerri, C. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt164 · Cited by 117 · see citing works
Toll‐like receptors in neuroinflammation, neurodegeneration, and alcohol‐induced brain damage
Pascual, M., Calvo-Rodríguez, M., Núñez, L., Villalobos, C., Ureña, J., & Guerri, C. (2021) · IUBMB Life · doi:10.1002/iub.2510 · Cited by 114 · see citing works
Broadwater, M., Liu, W., Crews, F. T., & SPEAR, L. P. (2014) · Developmental Neuroscience · doi:10.1159/000362874 · Cited by 101 · see citing works
Self-citationMicroglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development
Catale, C., Gironda, S. C., Iacono, L. L., & Carola, V. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020468 · Cited by 99 · see citing works
Nunes, P. T., Kipp, B. T., Reitz, N. L., & Savage, L. M. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.09.002 · Cited by 98 · see citing works
Vetreno, R. P., Broadwater, M., Liu, W., SPEAR, L. P., & Crews, F. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113421 · Cited by 101 · see citing works
Self-citationPeng, H., Geil, C., Chen, K. Y., McClain, J. A., & Nixon, K. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.02.175 · Cited by 95 · see citing works
Skorput, A. G. J., Gupta, V. P., Yeh, P. W. L., & Yeh, H. H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1462-15.2015 · Cited by 92 · see citing works
Li, J., Wang, H., Liu, D., Li, X., He, L., Pan, J., Shen, Q., & Peng, Y. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.001 · Cited by 92 · see citing works
Innate Immune Signaling and Alcohol Use Disorders
Coleman, L. G., & Crews, F. T. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_92 · Cited by 90 · see citing works
Self-citationKyzar, E. J., Floreani, C. V., Teppen, T. L., & Pandey, S. C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00222 · Cited by 89 · see citing works
Vetreno, R. P., Lawrimore, C. J., Rowsey, P. J., & Crews, F. T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00200 · Cited by 89 · see citing works
Self-citationDoremus‐Fitzwater, T. L., Gano, A., Paniccia, J. E., & Terrence Deak, B. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.032 · Cited by 88 · see citing works
Alcohol, microbiome, and their effect on psychiatric disorders
Hillemacher, T., Bachmann, O. P., Kahl, K. G., & Frieling, H. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.04.015 · Cited by 87 · see citing works
Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse
Orío, L., Alén, F., Pavón, F. J., Serrano, A., & García‐Bueno, B. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00490 · Cited by 90 · see citing works
Boutros, N., Semenova, S., Liu, W., Crews, F. T., & Markou, A. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu003 · Cited by 80 · see citing works
Self-citationHMGB1/IL-1β complexes regulate neuroimmune responses in alcoholism
Coleman, L. G., Zou, J., Qin, L., & Crews, F. T. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.027 · Cited by 82 · see citing works
Self-citationFernandez, G. M., Lew, B. J., Vedder, L. C., & Savage, L. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.045 · Cited by 82 · see citing works
Vetreno, R. P., & Crews, F. T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204500 · Cited by 78 · see citing works
Self-citationImpact of neuroimmune activation induced by alcohol or drug abuse on adolescent brain development
Guerri, C., & Pascual, M. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.006 · Cited by 78 · see citing works
Potential of Glial Cell Modulators in the Management of Substance Use Disorders
Jones, J. D. (2020) · CNS Drugs · doi:10.1007/s40263-020-00721-9 · Cited by 78 · see citing works
Broadwater, M., & SPEAR, L. P. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.013 · Cited by 76 · see citing works
Alcohol and Stress Activation of Microglia and Neurons: Brain Regional Effects
Walter, T. J., Vetreno, R. P., & Crews, F. T. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13511 · Cited by 75 · see citing works
Self-citationLawrimore, C. J., & Crews, F. T. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13368 · Cited by 73 · see citing works
Self-citationOrio, L., Antón, M., Rodríguez-Rojo, I. C., Correas, Á., García-Bueno, B., Corral, M., de Fonseca, F. D., García-Moreno, L., Maestú, F., & Cadaveira, F. (2018) · Addiction Biology · doi:10.1111/adb.12543 · Cited by 67 · see citing works
Pascual, M., Montesinos, J., & Guerri, C. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24203 · Cited by 71 · see citing works
Vetreno, R. P., Bohnsack, J. P., Kusumo, H., Liu, W., Pandey, S. C., & Crews, F. T. (2019) · Addiction Biology · doi:10.1111/adb.12731 · Cited by 71 · see citing works
Self-citationMost, D., Ferguson, L. B., & Harris, R. A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00006-9 · Cited by 70 · see citing works
Current hypotheses on the mechanisms of alcoholism
Vetreno, R. P., & Crews, F. T. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00027-6 · Cited by 71 · see citing works
Self-citationVetreno, R. P., Yaxley, R. H., Paniagua, B., & Crews, F. T. (2015) · Addiction Biology · doi:10.1111/adb.12232 · Cited by 69 · see citing works
Self-citationSchindler, A. G., Tsutsui, K. T., & Clark, J. J. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12404 · Cited by 67 · see citing works
Broadwater, M., Lee, S., Yu, Y., Hongtu Zhu, B., Crews, F. T., Robinson, D. L., & Shih, Y. I. (2017) · Addiction Biology · doi:10.1111/adb.12530 · Cited by 68 · see citing works
Self-citationRisher, M., Sexton, H. G., Risher, W. C., Wilson, W. A., Fleming, R. L., Madison, R. D., Moore, S. D., Eroğlu, Ç., & Swartzwelder, H. S. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12913 · Cited by 69 · see citing works
Fernandez, G. M., & Savage, L. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.013 · Cited by 67 · see citing works
Barnett, A., David, E., Rohlman, A., Nikolova, V. D., Moy, S. S., Vetreno, R. P., & Coleman, L. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.884170 · Cited by 62 · see citing works
Self-citationVetreno, R. P., Yaxley, R., Paniagua, B., Johnson, G. A., & Crews, F. T. (2017) · Addiction Biology · doi:10.1111/adb.12364 · Cited by 60 · see citing works
Self-citationSanchez-Marin, L., Pavon, F. J., Decara, J., Suarez, J., Gavito, A., Castilla-Ortega, E., Rodriguez de Fonseca, F., & Serrano, A. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00015 · Cited by 55 · see citing works
Liu, W., & Crews, F. T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.014 · Cited by 53 · see citing works
Self-citationAdolescence and Alcohol: a review of the literature
Skala, K., & Walter, H. (2013) · Neuropsychiatrie · doi:10.1007/s40211-013-0066-6 · Cited by 52 · see citing works
Bajo, M., Madamba, S. G., Roberto, M., Blednov, Y. A., Sagi, V. N., Roberts, E., Rice, K. C., Harris, R. A., & Siggins, G. R. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.007 · Cited by 49 · see citing works
Lang, R., Li, H., Luo, X., Liu, C., Zhang, Y., Guo, S., Xu, J., Bao, C., Dong, W., & Yu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1008072 · Cited by 47 · see citing works
Fernandez, G. M., Stewart, W. N., & Savage, L. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149987 · Cited by 47 · see citing works
Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder
Liu, W., Vetreno, R. P., & Crews, F. T. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0698-4 · Cited by 47 · see citing works
Self-citationMacht, V. A., Elchert, N., & Crews, F. T. (2020) · Brain Sciences · doi:10.3390/brainsci10110785 · Cited by 48 · see citing works
Self-citationVetreno, R. P., Patel, Y. N., Patel, U., Walter, T. J., & Crews, F. T. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.018 · Cited by 46 · see citing works
Self-citationBrain pathways to recovery from alcohol dependence
Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M. M., Matochik, J. A., Crews, F. T., Chandler, L. J., Pfefferbaum, A., et al. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.04.006 · Cited by 45 · see citing works
Self-citationTeng, S. X., Katz, P. S., Maxi, J. K., Mayeux, J. P., Gilpin, N. W., & Molina, P. E. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.006 · Cited by 46 · see citing works
Swartzwelder, H. S., Acheson, S. K., Miller, K. M., Sexton, H. G., Liu, W., Crews, F. T., & Risher, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140042 · Cited by 44 · see citing works
Self-citationSerotonin's Complex Role in Alcoholism: Implications for Treatment and Future Research
Marcinkiewcz, C. A., Lowery‐Gionta, E. G., & Kash, T. L. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13076 · Cited by 43 · see citing works
Microglia Phenotypes Following the Induction of Alcohol Dependence in Adolescent Rats
Peng, H., & Nixon, K. (2021) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14504 · Cited by 43 · see citing works
Microbiome and substances of abuse
Salavrakos, M., Leclercq, S., de Timary, P., & Dom, G. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110113 · Cited by 43 · see citing works
Crews, F. T., Fisher, R., Deason, C., & Vetreno, R. P. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.652494 · Cited by 43 · see citing works
Self-citationTranslational Research on Habit and Alcohol
McKim, T. H., Shnitko, T. A., Robinson, D. L., & Boettiger, C. A. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0089-8 · Cited by 41 · see citing works
Melbourne, J. K., Thompson, K. R., Peng, H., & Nixon, K. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.011 · Cited by 40 · see citing works
Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans
López‐Moreno, J. A., Marcos, M., Calleja‐Conde, J., Echeverry‐Alzate, V., Bühler, K., Costa‐Alba, P., Bernardo, E., Laso, F. J., de Fonseca, F. R., Nadal, R. A., et al. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12850 · Cited by 39 · see citing works
Randall, P. A., Vetreno, R. P., Makhijani, V. H., Crews, F. T., & Besheer, J. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13919 · Cited by 39 · see citing works
Self-citationLiu, W., & Crews, F. T. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00151 · Cited by 39 · see citing works
Self-citationMelbourne, J. K., Chandler, C. M., Van Doorn, C. E., Bardo, M. T., Pauly, J. R., Peng, H., & Nixon, K. (2021) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14694 · Cited by 37 · see citing works
Mineur, Y. S., Garcia‐Rivas, V., Thomas, M. A., Soares, A. R., McKee, S. A., & Picciotto, M. R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06120-w · Cited by 37 · see citing works
Tucker, A. E., Pauneto, C. D. M. A., Barnett, A., & Coleman, L. G. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.886634 · Cited by 33 · see citing works
Galaj, E., Kipp, B. T., Floresco, S., & Savage, L. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.062 · Cited by 34 · see citing works
Holloway, K. N., Douglas, J. C., Rafferty, T. M., Kane, C. J. M., & Drew, P. D. (2023) · Cells · doi:10.3390/cells12162109 · Cited by 32 · see citing works
Silva-Gotay, A., Davis, J., Tavares, E. R., & Richardson, H. N. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108698 · Cited by 32 · see citing works
McMurray, M. S., Amodeo, L. R., & Roitman, J. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100697 · Cited by 32 · see citing works
Ferguson, C., McKay, M., Harris, R. A., & Homanics, G. E. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.09.043 · Cited by 31 · see citing works
Wang, X., Yu, H. Q., Wang, C., Liu, Y., You, J., Wang, P., Xu, G., Shen, H., Yao, H., Lan, X., et al. (2020) · Toxicology · doi:10.1016/j.tox.2020.152625 · Cited by 31 · see citing works
Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat
Yetnikoff, L., Reichard, R. A., Schwartz, Z. M., Parsely, K. P., & Zahm, D. S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23459 · Cited by 30 · see citing works
Smith, B. L., & Reyes, T. M. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.007 · Cited by 30 · see citing works
Wei, Z., Chen, L., Zhang, J., & Cheng, Y. (2020) · Addiction · doi:10.1111/add.15160 · Cited by 31 · see citing works
Boschen, K. E., Ptacek, T., Berginski, M. E., Simon, J. M., & Parnell, S. E. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049012 · Cited by 30 · see citing works
Robinson, D. L., Amodeo, L. R., Chandler, L. J., Crews, F. T., Ehlers, C. L., Gómez‐A, A., Healey, K. L., Kuhn, C. M., Macht, V. A., Marshall, S. A., et al. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.07.007 · Cited by 30 · see citing works
Self-citationBinge ethanol in adulthood exacerbates negative outcomes following juvenile traumatic brain injury
Karelina, K., Gaier, K. R., Prabhu, M., Wenger, V., Corrigan, T. E. D., & Weil, Z. M. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.009 · Cited by 30 · see citing works
Alcohol, HMGB1, and Innate Immune Signaling in the Brain
Crews, F. T. (2024) · Alcohol research · doi:10.35946/arcr.v44.1.04 · Cited by 28 · see citing works
Self-citationRole of toll-like receptor 7 (TLR7) in voluntary alcohol consumption
Grantham, E. K., Warden, A. S., McCarthy, G. S., DaCosta, A., Mason, S., Blednov, Y. A., Mayfield, R. D., & Harris, R. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.029 · Cited by 28 · see citing works
Van Hees, L., Didone, V., Charlet‐Briart, M., Van Ingelgom, T., Alexandre, A., Quertemont, E., Nguyen, L., & Laguesse, S. (2022) · Addiction Biology · doi:10.1111/adb.13102 · Cited by 27 · see citing works
Reitz, N. L., Nunes, P. T., & Savage, L. M. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.772857 · Cited by 26 · see citing works
Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling
Lawrimore, C. J., Coleman, L. G., & Crews, F. T. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5153-8 · Cited by 27 · see citing works
Self-citationAntón, M., Rodríguez‐González, A., Rodríguez‐Rojo, I. C., Pastor, A., Correas, Á., Serrano, A., Ballesta, A., Alén, F., de Heras, R. G., de la Torre, R., et al. (2017) · Addiction Biology · doi:10.1111/adb.12580 · Cited by 26 · see citing works
Crews, F. T., Coleman, L. G., Macht, V. A., & Vetreno, R. P. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000710 · Cited by 26 · see citing works
Self-citationMacht, V. A., Vetreno, R. P., Elchert, N., & Crews, F. T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02243-7 · Cited by 24 · see citing works
Self-citation
- Authors
- Vetreno, R. P., & Crews, F. T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Vetreno, R.P.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 226
- Pages
- 475-488
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3740555
- OpenAlex
- W2089714619
- Cited by
- 183
- References
- 66
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 13 · 2023: 8 · 2022: 16 · 2021: 23 · 2020: 14 · 2019: 14 · 2018: 9 · 2017: 20 · 2016: 15 · 2015: 15 · 2014: 11 · 2013: 8
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Center for Alcohol Studies
- National Institutes of Health (AA-11605, AA007573, AA019767)
- National Institute on Alcohol Abuse and Alcoholism (P50AA011605, AA 11605, U24AA020022, U01AA020023, AA020023, L40 AA021590, AA021040, AA 007573, F32AA021040, AA020022, AA020024, U24AA020024, U54AA019767, AA019767, P60AA011605, T32AA007573)
- Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- adolescent binge drinking, prefrontal cortex, HMGB1, danger signaling, TLR4, TLR3, neuroinflammation, innate immunity, spatial learning, perseveration, neurocognitive impairment, alcohol abuse
- MeSH terms
- Adolescent, Animals, Cognition Disorders, Female, Fluorescent Antibody Technique, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Reversal Learning, Rats, Wistar, Prefrontal Cortex, Microscopy, Confocal, Maze Learning, HMGB1 Protein, Toll-Like Receptors, Toll-Like Receptor 3, Toll-Like Receptor 4, Rats, Real-Time Polymerase Chain Reaction, Binge Drinking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
