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Analysis of refill liquids for electronic cigarettes

Open access
Etter, Jean‐François, Zäther, Eva, Svensson, Sofie·2013·Addiction

Abstract

Aims: To assess levels of nicotine, nicotine degradation products and some specific impurities in commercial refill liquids for electronic cigarettes. Design and setting: We analyzed 20 models of 10 of the most popular brands of refill liquids, using gas and liquid chromatography. Measurements: We assessed nicotine content, content of the known nicotine degradation products and impurities, and presence of ethylene glycol and diethylene glycol. Findings: The nicotine content in the bottles corresponded closely to the labels on the bottles. The levels of nicotine degradation products represented 0–4.4% of those for nicotine, but for most samples the level was 1–2%. Cis‐N‐oxide, trans‐N‐oxide, myosmine, anatabine and anabasine were the most common additional compounds found. Neither ethylene glycol nor diethylene glycol were detected. Conclusion: The nicotine content of electronic cigarette refill bottles is close to what is stated on the label. Impurities are detectable in several brands above the level set for nicotine products in the European Pharmacopoeia, but below the level where they would be likely to cause harm.

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Metadata

Authors
Etter, J., Zäther, E., & Svensson, S.
Venue
Addiction
Publisher
Wiley
Published
2013-05-23
Volume
108
Issue
9
Pages
1671-1679
ISSN
  • 0965-2140 (ISSN-L)
  • 1360-0443
OpenAlex
W2101758114
Cited by
232
References
0
FWCI
19.99
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Analysis of refill liquids for electronic cigarettes. https://app.cochat.ai/papers/10.1111/add.12235
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Etter, J., Zäther, E., & Svensson, S. (2013). Analysis of refill liquids for electronic cigarettes. Addiction. https://doi.org/10.1111/add.12235

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