The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals

Double muscling in cattle due to mutations in the myostatin gene

McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039 · see citing works

A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle

Grobet, L., Royo Martin, L. J., Poncelet, D., Pirottin, D., Brouwers, B., Riquet, J., Schoeberlein, A., Dunner, S., Ménissier, F., Massabanda, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0997-71 · Cited by 1,556 · see citing works

Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child

Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399 · see citing works

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260 · see citing works

Mutations in <i>myostatin</i> ( <i>GDF8</i> ) in Double-Muscled Belgian Blue and Piedmontese Cattle

Kambadur, R., Sharma, M., Smith, T. P. L., & Bass, J. J. (1997) · Genome Research · doi:10.1101/gr.7.9.910 · Cited by 1,204 · see citing works

Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation

Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., & Kambadur, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004356200 · Cited by 1,014 · see citing works

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

Rudnicki, M. A., Braun, T. W., Hinuma, S., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90508-a · Cited by 984 · see citing works

Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression

Langley, B. C., Thomas, M., Bishop, A., Sharma, M., Gilmour, S., & Kambadur, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204291200 · Cited by 910 · see citing works

A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs

Mosher, D. S., Quignon, P., Bustamante, C. D., Sutter, N. B., Mellersh, C. S., Parker, H. G., & Ostrander, E. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030079 · Cited by 826 · see citing works

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Trendelenburg, A. U., Meyer, A., Rohner, D., Boyle, J., Hatakeyama, S., & Glass, D. J. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00105.2009 · Cited by 792 · see citing works

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

Wolfman, N. M., McPherron, A. C., Pappano, W. N., Davies, M. V., Song, K., Tomkinson, K. N., Wright, J. F., Zhao, L., Sebald, S. M., Greenspan, D. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2534946100 · Cited by 454 · see citing works

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

Lach-Trifilieff, E., Minetti, G. C., Sheppard, K., Ibebunjo, C., Feige, J. N., Hartmann, S., Brachat, S., Rivet, H., Koelbing, C., Morvan, F., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01307-13 · Cited by 306 · see citing works

The genetics of vertebrate myogenesis

Bryson‐Richardson, R. J., & Currie, P. D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2369 · Cited by 285 · see citing works

Growth- and breed-related changes of muscle fiber characteristics in cattle.

Wegner, J., Albrecht, E., Fiedler, I., Teuscher, F., Papstein, H. ‐., & Ender, K. (2000) · Journal of Animal Science · doi:10.2527/2000.7861485x · Cited by 276 · see citing works

Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds

Petersen, J. L., Mickelson, J. R., Rendahl, A., Valberg, S. J., Andersson, L. S., Axelsson, J., Bailey, E., Bannasch, D. L., Binns, M. M., Borges, A. S., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003211 · Cited by 268 · see citing works

Myostatin expression in porcine tissues: tissue specificity and developmental and postnatal regulation

Ji, S., Losinski, R. L., Cornelius, S. G., Frank, G. R., Willis, G. M., Gerrard, D. E., Depreux, F. F. S., & Spurlock, M. E. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.4.r1265 · Cited by 246 · see citing works

Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscle

Girgenrath, S., Song, K., & Whittemore, L.-A. (2004) · Muscle & Nerve · doi:10.1002/mus.20175 · Cited by 228 · see citing works

Appearances can be deceiving: phenotypes of knockout mice

Barbaric, I., Miller, G., & Dear, T. N. (2007) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/elm008 · Cited by 195 · see citing works

Myostatinand its implications on animal breeding: a review

Bellinge, R. H. S., Liberles, D. A., Iaschi, S. P. A., O’Brien, P. A., & Tay, G. K. (2005) · Animal Genetics · doi:10.1111/j.1365-2052.2004.01229.x · Cited by 192 · see citing works

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs

Qian, L., Tang, M., Yang, J., Wang, Q., Cai, C., Jiang, S., Li, H., Jiang, K., Gao, P., Ma, D., et al. (2015) · Scientific Reports · doi:10.1038/srep14435 · Cited by 190 · see citing works

Activin A more prominently regulates muscle mass in primates than does GDF8

Latres, E., Mastaitis, J., Fury, W., Miloscio, L., Trejos, J., Pangilinan, J., Okamoto, H., Cavino, K., Na, E., Papatheodorou, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15153 · Cited by 185 · see citing works

A molecular mechanism enabling continuous embryonic muscle growth – a balance between proliferation and differentiation

Amthor, H., Christ, B., & Patel, K. J. (1999) · Development · doi:10.1242/dev.126.5.1041 · Cited by 170 · see citing works

Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat

Fiems, L. O. (2012) · Animals · doi:10.3390/ani2030472 · Cited by 145 · see citing works

The Regulation and Action of Myostatin as a Negative Regulator of Muscle Development during Avian Embryogenesis

Amthor, H., Huang, R., McKinnell, I. W., Christ, B., Kambadur, R., Sharma, M., & Patel, K. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0812 · Cited by 138 · see citing works

Haplotype diversity of the myostatin gene among beef cattle breeds

Dunner, S., Miranda, M. E., Yves Amigues, F., Cañón, J., Georges, M., Hanset, R., Williams, J. L., & Ménissier, F. (2003) · Genetics Selection Evolution · doi:10.1186/1297-9686-35-1-103 · Cited by 135 · see citing works

Analysis of HorseMyostatinGene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types

Dall’Olio, S., Fontanesi, L., Costa, L. N., Tassinari, M., Minieri, L., & Falaschini, A. (2010) · BioMed Research International · doi:10.1155/2010/542945 · Cited by 133 · see citing works

Generation of gene-target dogs using CRISPR/Cas9 system

Zou, Q., Wang, X., Liu, Y., Ouyang, Z., Long, H., Wei, S. H., Xin, J., Zhao, B., Lai, S., Shen, J., et al. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv061 · Cited by 132 · see citing works

Association of the muscle hypertrophy locus with carcass traits in beef cattle.

Casas, E., Keele, J. W., Shackelford, T. K., Koohmaraie, M., Sonstegard, T. S., Smith, T. P. L., Kappes, S. M., & STONE, R. T. (1998) · Journal of Animal Science · doi:10.2527/1998.762468x · Cited by 127 · see citing works

Evidence for multiple alleles effecting muscling and fatness at the Ovine GDF8 locus

Kijas, J., McCulloch, R. J., Edwards, J. E. H., Oddy, V. H., Lee, S., & van der Werf, J. H. J. (2007) · BMC Genetics · doi:10.1186/1471-2156-8-80 · Cited by 127 · see citing works

The genetic origin and history of speed in the Thoroughbred racehorse

Bower, M. A., McGivney, B. A., Campana, M. G., Gu, J., Andersson, L. S., Barrett, E., Davis, C. R., Mikko, S., Stock, F., Воронкова, В. Н., et al. (2012) · Nature Communications · doi:10.1038/ncomms1644 · Cited by 126 · see citing works

Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA

Binns, M. M., Boehler, D. A., & Lambert, D. H. (2010) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02126.x · Cited by 120 · see citing works

A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis aries)

Boman, I. A., Klemetsdal, G., Blichfeldt, T., Nafstad, O., & Våge, D. I. (2009) · Animal Genetics · doi:10.1111/j.1365-2052.2009.01855.x · Cited by 116 · see citing works

Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep

Hadjipavlou, G., Matika, O., Clop, A., & Bishop, S. C. (2008) · Animal Genetics · doi:10.1111/j.1365-2052.2008.01734.x · Cited by 103 · see citing works

Characterization of the complete porcine MSTN gene and expression levels in pig breeds differing in muscularity

Stinckens, A., Luyten, T., Bijttebier, J., den Maagdenberg, K. V., Dieltiens, D., Janssens, S., SMET, S. D., Georges, M., & Buys, N. (2008) · Animal Genetics · doi:10.1111/j.1365-2052.2008.01774.x · Cited by 102 · see citing works

Double muscling in Marchigiana beef breed is caused by a stop codon in the third exon of myostatin gene

Marchitelli, C., Savarese, M. C., Crisà, A., Nardone, A., Ajmone‐Marsan, P., & Valentini, A. (2003) · Mammalian Genome · doi:10.1007/s00335-002-2176-5 · Cited by 100 · see citing works

Effects of the myostatin F94L substitution on beef traits1

Esmailizadeh, A., Bottema, C. D. K., Sellick, G. S., Verbyla, A. P., Morris, C. A., Cullen, N. G., & Pitchford, W. S. (2008) · Journal of Animal Science · doi:10.2527/jas.2007-0589 · Cited by 99 · see citing works

The Function of Myostatin in the Regulation of Fat Mass in Mammals

Deng, B., Zhang, F., Wen, J., Ye, S., Wang, L., Yang, Y., Gong, P., & Jiang, S. (2017) · Nutrition &amp; Metabolism · doi:10.1186/s12986-017-0179-1 · Cited by 98 · see citing works

The TGFβ superfamily in stem cell biology and early mammalian embryonic development

Beyer, T. A., Narimatsu, M., Weiss, A., David, L., & Wrana, J. L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.025 · Cited by 91 · see citing works

Structure of Myostatin·Follistatin-like 3

Cash, J. N., Angerman, E. B., Kattamuri, C., Nolan, K., Zhao, H., Sidis, Y., Keutmann, H. T., & Thompson, T. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.270801 · Cited by 86 · see citing works

Comparison of Texel- and Suffolk-sired crossbred lambs for survival, growth, and compositional traits

Leymaster, K. A., & Jenkins, T. G. (1993) · Journal of Animal Science · doi:10.2527/1993.714859x · Cited by 85 · see citing works

Effects of Stress on Cattle with Hereditary Muscular Hypertrophy

Holmes, J. H. G., Ashmore, C. R., & Robinson, D. W. (1973) · Journal of Animal Science · doi:10.2527/jas1973.364684x · Cited by 78 · see citing works

CRISPR /Cas9‐mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass

Wang, X., Niu, Y., Zhou, J., Zhu, H., Ma, B., Yu, H., Yan, H., Hua, J., Huang, X., Qu, L., et al. (2018) · Animal Genetics · doi:10.1111/age.12626 · Cited by 78 · see citing works

A genome‐wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene

Tozaki, T., Miyake, T., Kakoi, H., Gawahara, H., Sugita, S., Hasegawa, T., Ishida, N., Hirota, K., & Nakano, Y. (2010) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02095.x · Cited by 75 · see citing works

Effect of myostatin F94L on carcass yield in cattle

Sellick, G. S., Pitchford, W. S., Morris, C. A., Cullen, N. G., Crawford, A. M., Raadsma, H. W., & Bottema, C. D. K. (2007) · Animal Genetics · doi:10.1111/j.1365-2052.2007.01623.x · Cited by 75 · see citing works

Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed

Wiener, P., Smith, J. A., Lewis, A. M., Woolliams, J. A., & Williams, J. L. (2002) · Genetics Selection Evolution · doi:10.1186/1297-9686-34-2-221 · Cited by 73 · see citing works

Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens

Ye, X., Brown, S. R., Nones, K., Coutinho, L. L., Dekkers, J. C. M., & Lamont, S. J. (2007) · Genetics Selection Evolution · doi:10.1186/1297-9686-39-1-73 · Cited by 64 · see citing works

Polymorphisms of myostatin gene (MSTN) in four goat breeds and their effects on Boer goat growth performance

Zhang, C., Liu, Y., Xu, D.-Q., Wen, Q., Li, X. O., Zhang, W., & Yang, L. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1071-0 · Cited by 63 · see citing works

On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed. I. Experimental data

Hanset, R., & Michaux, C. (1985) · Genetics Selection Evolution · doi:10.1186/1297-9686-17-3-359 · Cited by 59 · see citing works

Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle

Grisolia, A. B., Angelo, G. T. D., Neto, L. R. P., Siqueira, F., & Garcia, J. F. (2009) · Genetics and Molecular Research · doi:10.4238/vol8-3gmr548 · Cited by 57 · see citing works

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K., Solbrå, A. V., Bruusgaard, J. C., Joch, B., Sartori, R., Giallourou, N., et al. (2016) · eLife · doi:10.7554/elife.16940 · Cited by 57 · see citing works

Functional effect of mir-27b on myostatin expression: a relationship in piedmontese cattle with double-muscled phenotype

Miretti, S., Martignani, E., Accornero, P., & Baratta, M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-194 · Cited by 54 · see citing works

The single nucleotide polymorphisms of the chicken myostatin gene are associated with skeletal muscle and adipose growth

Gu, Z. (2004) · Science in China Series C Life Sciences · doi:10.1360/02yc0201 · Cited by 49 · see citing works

An insertion in the coding region of the myostatin (MSTN) gene affects carcass conformation and fatness in the Norwegian Spælsau (Ovis aries)

Boman, I. A., & Våge, D. I. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-98 · Cited by 48 · see citing works

Comparison of contractile characteristics of muscle from Holstein and double-muscled Belgian Blue foetuses

Deveaux, V., Cassar‐Malek, I., & Picard, B. B. (2001) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(01)00459-7 · Cited by 43 · see citing works

Analysis of the Single-Nucleotide Polymorphism in the 5′UTR and Part of Intron I of the Sheep MSTN Gene

Sjakste, T., Paramonova, N., Grīslis, Z., Ilva, T., & Kairiša, D. (2011) · DNA and Cell Biology · doi:10.1089/dna.2010.1153 · Cited by 41 · see citing works

INVITED REVIEW: Inhibitors of myostatin as methods of enhancing muscle growth and development1

Chen, P. R., & Lee, K. (2016) · Journal of Animal Science · doi:10.2527/jas.2016-0532 · Cited by 41 · see citing works

Influence of single nucleotide polymorphisms in the myostatin and myogenic factor 5 muscle growth-related genes on the performance traits of Marchigiana beef cattle1

Sarti, F. M., Lasagna, E., Ceccobelli, S., Lorenzo, P. D., Filippini, F., Sbarra, F., Giontella, A., Pieramati, C., & Panella, F. (2014) · Journal of Animal Science · doi:10.2527/jas.2014-7669 · Cited by 39 · see citing works

Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse

Matsakas, A., Otto, A., Elashry, M. I., Brown, S., & Patel, K. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1065 · Cited by 37 · see citing works

Polymorphism of Myostatin Gene in Intron 1 and 2 and Exon 3, and Their Associations with Yearling Weight, Using PCR-RFLP and PCR-SSCP Techniques in Zel Sheep

Dehnavi, E., Azari, M. A., Hasani, S., Nassiry, M. R., Mohajer, M., Ahmadi, A., Shahmohamadi, L., & Yousefi, S. (2012) · Biotechnology Research International · doi:10.1155/2012/472307 · Cited by 32 · see citing works

Deep Intronic Mutation and Pseudo Exon Activation as a Novel Muscular Hypertrophy Modifier in Cattle

Bouyer, C., Forestier, L., Renand, G., & Oulmouden, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097399 · Cited by 32 · see citing works

Genetic variations in the myostatin gene (MSTN) in New Zealand sheep breeds

Han, J., Forrest, R. H.-J., & Hickford, J. G. H. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2752-7 · Cited by 32 · see citing works

Association of myostatin (MSTN) gene polymorphisms with morphological traits in the Italian Heavy Draft Horse breed

Dall’Olio, S., Wang, Y., Sartori, C., Fontanesi, L., & Mantovani, R. (2013) · Livestock Science · doi:10.1016/j.livsci.2013.12.002 · Cited by 31 · see citing works

Variation in the coding region of the myostatin (GDF8) gene in sheep

Zhou, H., Hickford, J. G. H., & Fang, Q. (2007) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2007.08.004 · Cited by 29 · see citing works

Short Communication Polymorphisms of the myostatin gene (MSTN) and its relationship with growth traits in goat breeds

Zhang, Z. J., Ling, Y., Wang, L. J., Hang, Y. F., Guo, X., Zhang, Y.-H., Ding, J. P., & Zhang, X. R. (2013) · Genetics and Molecular Research · doi:10.4238/2013.april.2.12 · Cited by 27 · see citing works

Single‐nucleotide polymorphism identification in the caprine myostatin gene

Li, X. L., Wu, Z. L., Yan Fang, G. O. N. G., Liu, Y. Q., Liu, Z. Z., Wang, X. J., Xin, T., & Ji, Q. (2006) · Journal of Animal Breeding and Genetics · doi:10.1111/j.1439-0388.2006.00572.x · Cited by 25 · see citing works

IDENTIFICATION OF THREE SNPs IN THE PORCINE MYOSTATIN GENE (MSTN)

Jiang, Y., Li, N., Plastow, G. S., Liu, Z. L., Hu, X., & Wu, C. (2002) · Animal Biotechnology · doi:10.1081/abio-120005778 · Cited by 24 · see citing works

Identification of polymorphisms in the rabbit (Oryctolagus cuniculus) myostatin (MSTN) gene and association analysis with finishing weight in a commercial rabbit population

Fontanesi, L., Scotti, E., Frabetti, A., Fornasini, D., Picconi, A. M., & Russo, V. C. (2011) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02163.x · Cited by 24 · see citing works

Characterisation of connective tissue from the hypertrophic skeletal muscle of myostatin null mice

Elashry, M. I., Collins‐Hooper, H., Vaiyapuri, S., & Patel, K. (2012) · Journal of Anatomy · doi:10.1111/j.1469-7580.2012.01503.x · Cited by 23 · see citing works

A new single nucleotide polymorphism in the rabbit (Oryctolagus cuniculus)myostatin(MSTN) gene is associated with carcass composition traits

Sternstein, I., Reißmann, M., Maj, D., Bieniek, J., & Brockmann, G. A. (2014) · Animal Genetics · doi:10.1111/age.12165 · Cited by 23 · see citing works

Real-time PCR genotyping and frequency of the myostatin F94L mutation in beef cattle breeds

Vankan, D. M., Waine, D., & Fortes, M. R. S. (2009) · animal · doi:10.1017/s175173110999139x · Cited by 22 · see citing works

Single nucleotide polymorphisms in the upstream regulatory region alter the expression of myostatin

Hu, W., Chen, S., Zhang, R., & Lin, Y. (2013) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-013-9621-5 · Cited by 22 · see citing works

The role of the myostatin protein in meat quality – a review

Kobolák, J., & Gócza, E. (2002) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-45-159-2002 · Cited by 22 · see citing works

Two single nucleotide polymorphisms in the promoter of the ovine myostatin gene ( MSTN ) and their effect on growth and carcass muscle traits in N ew Z ealand R omney sheep

Wang, J., Zhou, H., Hu, J., Li, S., Luo, Y., & Hickford, J. G. H. (2015) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12171 · Cited by 21 · see citing works

ÉTUDE DU CARACTÈRE CULARD. III. — ANATOMIE MICROSCOPIQUE COMPARÉE DU TISSU MUSCULAIRE DE MÂLES charolais NORMAUX ET CULARDS

OUHAYOUN, J., & BEAUMONT, A. (1968) · Annales de Zootechnie · doi:10.1051/animres:19680208 · Cited by 19 · see citing works

Characterization of myostatin gene (MSTN) of Pekin duck and the association of its polymorphism with breast muscle traits

Xu, T., Gu, L., Zhang, X.-P., Ye, B., Liu, X. L., & Hou, S. (2013) · Genetics and Molecular Research · doi:10.4238/2013.february.28.18 · Cited by 18 · see citing works

SNP identification and polymorphism analysis in exon 2 of the horse myostatin gene

Baron, E. E., Lopes, M. S., Mendonça, D., & Machado, A. D. C. (2011) · Animal Genetics · doi:10.1111/j.1365-2052.2011.02229.x · Cited by 16 · see citing works

Single nucleotide polymorphisms of myostatin gene in Chinese domestic horses

Li, R., Liu, D., Cao, C., Wang, S., Dang, R., Lan, X., Chen, H., Zhang, T., Liu, W., & Lei, C. (2013) · Gene · doi:10.1016/j.gene.2013.12.027 · Cited by 14 · see citing works

When Less Means More: Impact of Myostatin in Animal Breeding

Georges, M. (2010) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152210793663793 · Cited by 14 · see citing works

Polymorphisms of the Myostatin Gene and Its Relationship with Reproduction Traits in the Bian Chicken

Zhang, G., Zhang, L., Wei, Y., Wang, J., FuXiang, D., Dai, G., & Xie, K. (2012) · Animal Biotechnology · doi:10.1080/10495398.2012.681411 · Cited by 12 · see citing works

Molecular Cloning of Equine (Thoroughbred) Myostatin cDNA and Detection of Myostatin Precursor Proteins in the Serum.

Hosoyama, T., Kawada, S., OSHIUMI, R., YONEDA, S., SOETA, C., Yamanouchi, K., HASEGAWA, T., Ishida, N., MUKOYAMA, H., Ishii, N., et al. (2002) · Journal of Reproduction and Development · doi:10.1262/jrd.48.335 · Cited by 12 · see citing works

Polymorphisms in the myostatin gene and their association with growth and carcass traits in duck

Lu, J., Shuisheng, H., Huang, W., Junying, Y., & Wen-wu, W. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.512 · Cited by 12 · see citing works

Analysis of polymorphisms in the equine MSTN gene in Polish populations of horse breeds

Stefaniuk‐Szmukier, M., Ropka‐Molik, K., Piórkowska, K., Kulisa, M., & Podstawski, Z. (2016) · Livestock Science · doi:10.1016/j.livsci.2016.03.012 · Cited by 12 · see citing works

A molecular marker for the chicken myostatin gene (GDF8) maps to 7p11

Sazanov, A. A., Ewald, D., Buitkamp, J., & Fries, R. (1999) · Animal Genetics · doi:10.1046/j.1365-2052.1999.00526-7.x · Cited by 11 · see citing works

Rabbit MSTN gene polymorphisms and genetic effect analysis

Qiao, X. B., Xu, K., Li, B., Luan, X., Xia, T., & Fan, X. (2014) · Genetics and Molecular Research · doi:10.4238/2014.april.8.1 · Cited by 10 · see citing works

The Hypertrophic Marchigiana: physical and biochemical parameters for meat quality evaluation

Vincenti, F., Failla, S., Gigli, S., Lasagna, E., Landi, V., Mangione, A., Berti, C., & Sarti, F. M. (2007) · Italian Journal of Animal Science · doi:10.4081/ijas.2007.1s.491 · Cited by 9 · see citing works

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Review: Balancing Selection for Deleterious Alleles in Livestock

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Molecular Mechanisms and Current Treatment Options for Cancer Cachexia

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Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle

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Characterization and Comparative Transcriptomic Analysis of Skeletal Muscle in Pekin Duck at Different Growth Stages Using RNA-Seq

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The Functional Role of Long Non-Coding RNA in Myogenesis and Skeletal Muscle Atrophy

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When Less Is More: Targeting the Myostatin Gene in Livestock for Augmenting Meat Production

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Profiling of open chromatin in developing pig ( Sus scrofa ) muscle to identify regulatory regions

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Candidate genes for marker-assisted selection for growth, carcass and meat quality traits in rabbits

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A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

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Genetic Variations and Haplotypic Diversity in the Myostatin Gene of Different Cattle Breeds in Russia

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Generation of mutant pigs by lipofection-mediated genome editing in embryos

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Circular RNA circFNDC3AL Upregulates BCL9 Expression to Promote Chicken Skeletal Muscle Satellite Cells Proliferation and Differentiation by Binding to miR-204

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MyoG-enhanced circGPD2 regulates chicken skeletal muscle development by targeting miR-203a

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Metabolomic Profiling of Bos taurus Beef, Dairy, and Crossbred Cattle: A Between-Breeds Meta-Analysis

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Genome-Wide Association Analysis Reveals Novel Loci Related with Visual Score Traits in Nellore Cattle Raised in Pasture–Based Systems

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Differential effects of the venoms of Russell’s viper and Indian cobra on human myoblasts

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Lactiplantibacillus plantarum fermented barley extracts ameliorate high‐fat‐diet ‐induced muscle dysfunction via mitophagy

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A highly prevalent SINE mutation in the myostatin (MSTN) gene promoter is associated with low circulating myostatin concentration in Thoroughbred racehorses

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Myostatin Deficiency Enhances Antioxidant Capacity of Bovine Muscle via the SMAD‐AMPK‐G6PD Pathway

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Developmental Programming and Postnatal Modulations of Muscle Development in Ruminants

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Glutamine supplementation stimulates cell proliferation in skeletal muscle and cultivated myogenic cells of low birth weight piglets

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Population structure and identification of genomic regions associated with productive traits in five Italian beef cattle breeds

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Leveraging Functional Genomics for Understanding Beef Quality Complexities and Breeding Beef Cattle for Improved Meat Quality

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Myostatin site‐directed mutation and simultaneous PPARγ site‐directed knockin in bovine genome

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Metabolomic identification of pregnancy-specific biomarkers in blood plasma of BOS TAURUS beef cattle after transfer of in vitro produced embryos

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Effects of dietary fermented attachments of suspension cage as a replacement for sea mud on growth and intestinal health of sea cucumber Apostichopus japonicus

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Genetic variations and haplotypic diversity in the Myostatin gene of New Zealand cattle breeds

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Molecular signatures of muscle growth and composition deciphered by the meta-analysis of age-related public transcriptomics data

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Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses

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Research Note: Improved feed efficiency in quail with targeted genome editing in the myostatin gene

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Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury

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Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

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Potential link between microRNA-208 and cardiovascular diseases

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Molecular breeding of farm animals through gene editing

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Drosophila Models Reveal Properties of Mutant Lamins That Give Rise to Distinct Diseases

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Identification of Body Size Determination Related Candidate Genes in Domestic Pig Using Genome-Wide Selection Signal Analysis

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Expression of MSTN /Smad signaling pathway genes and its association with meat quality in Tibetan sheep (Ovis aries)

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Alterations in the fillet quality of myostatin-knockout red sea bream Pagrus major: Preliminary insights into nutritional, compositional, and textural properties

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Effect of myostatin inhibitor (myostatin pro-peptide) microinjection on in vitro maturation and subsequent early developmental stages of buffalo embryo

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MSTN knockout enhances the production of MYOD1-mediated steak-type cultivated meat

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Beyond the Big Five: Investigating Myostatin Structure, Polymorphism and Expression in Camelus dromedarius

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SNP screening of the MSTN gene and correlation analysis between genetic polymorphisms and growth traits in Dazu black goat

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Welfare of beef cattle

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Modern conception of myostatin biological role and clinical significance as the main regulator of muscle growth and differentiation

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A Genome-Wide Search for Candidate Genes of Meat Production in Jalgin Merino Considering Known Productivity Genes

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A Review on the Genetic Regulation of Myogenesis and Muscle Development

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Myostatin Knockout Limits Exercise-Induced Reduction in Bovine Erythrocyte Oxidative Stress by Enhancing the Efficiency of the Pentose Phosphate Pathway

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A comparative investigation on H3K27ac enhancer activities in the brain and liver tissues between wild boars and domesticated pigs

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Genetic variants in myostatin and its receptors promote elite athlete status

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Association Between Muscle Growth and Transcription of a Mutant MSTN Gene in Olive Flounder (Paralichthys olivaceus)

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A Myostatin ( MSTN −/− ) Knockout Buffalo Produced by CRISPR-Cas9 Mediated Genome Editing and Somatic Cell Nuclear Transfer

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Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway

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Applications of Myostatin in Poultry and Aquaculture - A Review

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