The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations
Abstract
Polymorphisms of the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been reported to be potentially associated with the risks of developing frontotemporal lobar degeneration (FTLD), with inconsistent conclusions. This study aims to comprehensively investigate the potential role of TREM2 variants in FTLD risks via a meta‐analysis. We included a total of eight eligible articles. For TREM2 rs75932628, we observed a significantly increased FTLD risk in the models of T vs. C [Association Test, odds ratio (OR) = 2.43, 95% confidence interval (CI) = 1.43∼4.14, P = 0.001], CT vs. CC (OR = 2.27, 95% CI = 1.39∼3.71, P = 0.001), CT + TT vs. CC (OR = 2.27, 95% CI = 1.38∼3.71, P = 0.001), and Carrier T vs. C (OR = 2.26, 95% CI = 1.38∼3.69, P = 0.001). Similarly, we observed positive results for TREM2 rs2234253 in all of the genetic models (all OR > 1, P = 0.030). Nevertheless, we did not observe any statistical difference between the case and control groups in the pooled analyses of TREM2 rs142232675 and rs143332484 (all P > 0.05). Our findings identified the rs75932628 and rs2234253 polymorphisms of the TREM2 gene as risk factors for FTLD in Caucasian populations.
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Variants in TREM2 increase an individual's risk of developing FTD.
“and variants in TREM2 increase an individual’s risk of developing FTD.319”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [319]
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- Authors
- Su, W., Shi, Z., Liu, S., Wang, X., Liu, S., & Ji, Y.
- Affiliations
- Tianjin Huanhu Hospital (CN)
- Department of Neurology Tianjin Huanhu Hospital Tianjin China
- Corresponding author
- Ji, Yong
- ORCID
- Venue
- Annals of Human Genetics
- Publisher
- Wiley
- Published
- 2018-01-10
- Volume
- 82
- Issue
- 4
- Pages
- 177-185
- ISSN
- 0003-4800 (ISSN-L)
- 1469-1809
- OpenAlex
- W2783278502
- Cited by
- 16
- References
- 27
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81300947, 81571057)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TREM2, frontotemporal lobar degeneration, genetic polymorphism, genetic susceptibility, Alzheimer's disease, Caucasian population
- MeSH terms
- Humans, Membrane Glycoproteins, Receptors, Immunologic, Confidence Intervals, Odds Ratio, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, White People, Frontotemporal Lobar Degeneration
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