Recent studies of genetic dysfunction in pelvic organ prolapse: The role of collagen defects
Abstract
Gynaecologists are becoming increasingly aware that women with a family history of prolapse are at an increased risk of prolapse refractory to treatment. In the past five years, several genetic mutations have been shown to correlate with increased prolapse susceptibility. These mutations can result in disordered collagen metabolism, which weaken the fascial support of the pelvic organs. This review examines the contemporary evidence regarding the role of collagen in prolapse.
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Obesity, which is related to morbidity, appears to be mitigated by both prehabilitation and the implementation of evidence informed early recovery after surgery programmes.
“Obesity, which is related to morbidity, appears to be mitigated by both prehabilitation and the implementation of evidence informed early recovery after surgery programmes [8, 9, 10, 11, 12, 13].”
From How Can We Improve the Assessment and Indifferent Outcomes From Pelvic Organ Prolapse Management From Conservative and Surgical Therapies? ICI‐RS 2025 (2026) · cites this paper as [11]
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Progress in the genetics and epigenetics of pelvic floor disorder
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Biochemistry and Ultrastructure of Pelvic Floor Tissues and Organs
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Study of pelvic organ prolapse as a predictor of osteoporotic fracture risk
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Model Prolaps Uteri Berdasarkan Risiko Klinis dan Biologi Molekular
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- Authors
- Lim, V. F., Khoo, J. K., Wong, V., & Moore, K. H.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Moore, Kate H.
- ORCID
- Moore, Kate H.
- Venue
- Australian and New Zealand Journal of Obstetrics and Gynaecology
- Publisher
- Wiley
- Published
- 2014-02-25
- Volume
- 54
- Issue
- 3
- Pages
- 198-205
- ISSN
- 0004-8666 (ISSN-L)
- 1479-828X
- OpenAlex
- W2006426554
- Cited by
- 44
- References
- 76
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 3 · 2017: 4 · 2016: 4
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian and New Zealand Journal of Obstetrics and Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- pelvic organ prolapse, genetic mutations, collagen defects, collagen metabolism, hereditary susceptibility
- MeSH terms
- Collagen, Female, Humans, Matrix Metalloproteinases, Pelvic Organ Prolapse
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