The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Molecular Diagnosis of Antibody-Mediated Rejection in Human Kidney Transplants
Open accessAbstract
Antibody-mediated rejection is the major cause of kidney transplant failure, but the histology-based diagnostic system misses most cases due to its requirement for C4d positivity. We hypothesized that gene expression data could be used to test biopsies for the presence of antibody-mediated rejection. To develop a molecular test, we prospectively assigned diagnoses, including C4d-negative antibody-mediated rejection, to 403 indication biopsies from 315 patients, based on histology (microcirculation lesions) and donor-specific HLA antibody. We then used microarray data to develop classifiers that assigned antibody-mediated rejection scores to each biopsy. The transcripts distinguishing antibody-mediated rejection from other conditions were mostly expressed in endothelial cells or NK cells, or were IFNG-inducible. The scores correlated with the presence of microcirculation lesions and donor-specific antibody. Of 45 biopsies with scores>0.5, 39 had been diagnosed as antibody-mediated rejection on the basis of histology and donor-specific antibody. High scores were also associated with unanimity among pathologists that antibody-mediated rejection was present. The molecular score also strongly predicted future graft loss in Cox regression analysis. We conclude that microarray assessment of gene expression can assign a probability of ABMR to transplant biopsies without knowledge of HLA antibody status, histology, or C4d staining, and predicts future failure.
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Agresti, A. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/0471249688 · Cited by 6,746
Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating
Steyerberg, E. W. (2019) · Statistics for Biology and Health · doi:10.1007/978-3-030-16399-0 · Cited by 3,281
Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions
Solez, K., Colvin, R. B., Racusen, L. C., Haas, M., Sis, B., Mengel, M., Halloran, P. F., Baldwin, W., Banfi, G., Collins, A. B., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02159.x · Cited by 1,857
Self-citationSellarés, J., de Freitas, D. G., Mengel, M., Reeve, J., Einecke, G., Sis, B., Hidalgo, L. G., Famulski, K., Matas, A., & Halloran, P. F. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03840.x · Cited by 1,590
Self-citation(2003) · Technometrics · doi:10.1198/tech.2003.s28 · Cited by 1,545
Significance of the Positive Crossmatch Test in Kidney Transplantation
Patel, R., & Terasaki, P. I. (1969) · New England Journal of Medicine · doi:10.1056/nejm196904032801401 · Cited by 1,508
MAQC Consortium (2010) · Nature Biotechnology · doi:10.1038/nbt.1665 · Cited by 889
Estimating classification error rate: Repeated cross-validation, repeated hold-out and bootstrap
Kim, J.-H. (2009) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2009.04.009 · Cited by 792
Sis, B., Mengel, M., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Baldwin, W. M., Bracamonte, E. R., Broecker, V., et al. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02987.x · Cited by 762
Self-citationAntibody-Mediated Microcirculation Injury Is the Major Cause of Late Kidney Transplant Failure
Einecke, G., Sis, B., Reeve, J., Mengel, M., Campbell, P. M., Hidalgo, L. G., Kaplan, B., & Halloran, P. F. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02799.x · Cited by 687
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Cited by
Haas, M., Loupy, A., Lefaucheur, C., Roufosse, C., Glotz, D., Seron, D., Nankivell, B. J., Halloran, P. F., Colvin, R. B., Akalin, E., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14625 · Cited by 1,041
Self-citationWu, H., Malone, A. F., Donnelly, E. L., Kirita, Y., Uchimura, K., Ramakrishnan, S. M., Gaut, J. P., & Humphreys, B. D. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018020125 · Cited by 417
Allorecognition and the spectrum of kidney transplant rejection
Callemeyn, J., Lamarthée, B., Koenig, A., Koshy, P., Thaunat, O., & Naesens, M. (2022) · Kidney International · doi:10.1016/j.kint.2021.11.029 · Cited by 189
Levitsky, J., Asrani, S. K., Schiano, T., Moss, A., Chavin, K., Miller, C., Guo, K., Zhao, L., Kandpal, M., Bridges, N., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15953 · Cited by 44
Metadata
- Authors
- Sellarés, J., Reeve, J., Loupy, A., Mengel, M., Sis, B., Skene, A., de Freitas, D. G., Kreepala, C., Hidalgo, L. G., Famulski, K. S., & Halloran, P. F.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 13
- Issue
- 4
- Pages
- 971-983
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1548929234
- Cited by
- 280
- References
- 49
- FWCI
- 21.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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