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Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
Open accessAbstract
The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia-reperfusion injury. We present the first patients transplanted using a normothermic machine perfusion (NMP) device that transports and stores an organ in a fully functioning state at 37°C. In this Phase 1 trial, organs were retrieved using standard techniques, attached to the perfusion device at the donor hospital, and transported to the implanting center in a functioning state. NMP livers were matched 1:2 to cold-stored livers. Twenty patients underwent liver transplantation after NMP. Median NMP time was 9.3 (3.5-18.5) h versus median cold ischaemia time of 8.9 (4.2-11.4) h. Thirty-day graft survival was similar (100% NMP vs. 97.5% control, p = 1.00). Median peak aspartate aminotransferase in the first 7 days was significantly lower in the NMP group (417 IU [84-4681]) versus (902 IU [218-8786], p = 0.03). This first report of liver transplantation using NMP-preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation. NMP may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
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Cited by
A randomized trial of normothermic preservation in liver transplantation
for the Consortium for Organ Preservation in Europe, Nasralla, D., Coussios, C. C., Mergental, H., Akhtar, M. Z., Butler, A. J., Ceresa, C. D. L., Chiocchia, V., Dutton, S. J., García-Valdecasas, J. C., et al. (2018) · Nature · doi:10.1038/s41586-018-0047-9 · Cited by 1,199
Self-citationCholangiocyte organoids can repair bile ducts after transplantation in the human liver
Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., et al. (2021) · Science · doi:10.1126/science.aaz6964 · Cited by 394
Observations on the ex situ perfusion of livers for transplantation
Watson, C. J. E., Kosmoliaptsis, V., Pley, C., Randle, L., Fear, C., Crick, K., Gimson, A. E., Allison, M., Upponi, S., Brais, R., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14687 · Cited by 355
Metadata
- Authors
- Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M. T. P. R., Quaglia, A., Holroyd, D., Vogel, T., Coussios, C. C., & Friend, P. J.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 16
- Issue
- 6
- Pages
- 1779-1787
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2233914793
- Cited by
- 496
- References
- 0
- FWCI
- 69.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M. T. P. R., Quaglia, A., Holroyd, D., Vogel, T., Coussios, C. C., & Friend, P. J. (2016). Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial. American Journal of Transplantation. https://doi.org/10.1111/ajt.13708
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