CoChat
Sign Up
Cited by 133Transplantation: Methods and OutcomesFrailty in Older AdultsClinical Nutrition and Gastroenterology

Frailty phenotypes and mortality after lung transplantation: a prospective cohort study

Open access
Singer, Jonathan P., Diamond, Joshua M., Anderson, Michaela R., Katz, Patricia P., Covinsky, Ken, Oyster, Michelle, Blue, Tatiana, Soong, Allison +21 more·2018·American Journal of Transplantation
DOI 10.1111/ajt.14873PMC PMC6105397
Open this paper in CoChat — free account

Abstract

Frailty is associated with increased mortality among lung transplant candidates. We sought to determine the association between frailty, as measured by the Short Physical Performance Battery (SPPB), and mortality after lung transplantation. In a multicenter prospective cohort study of adults who underwent lung transplantation, preoperative frailty was assessed with the SPPB (n = 318) and, in a secondary analysis, the Fried Frailty Phenotype (FFP; n = 299). We tested the association between preoperative frailty and mortality following lung transplantation with propensity score-adjusted Cox models. We calculated postestimation marginalized standardized risks for 1-year mortality by frailty status using multivariate logistic regression. SPPB frailty was associated with an increased risk of both 1- and 4-year mortality (adjusted hazard ratio [aHR]: 7.5; 95% confidence interval [CI]: 1.6-36.0 and aHR 3.8; 95%CI: 1.8-8.0, respectively). Each 1-point worsening in SPPB was associated with a 20% increased risk of death (aHR: 1.20; 95%CI: 1.08-1.33). Frail subjects had an absolute increased risk of death within the first year after transplantation of 12.2% (95%CI: 3.1%-21%). In secondary analyses, FFP frailty was associated with increased risk of death within the first postoperative year (aHR: 3.8; 95%CI: 1.1-13.2) but not over longer follow-up. Preoperative frailty is associated with an increased risk of death after lung transplantation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/ajt.14873

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Frailty is associated with increased waitlist and post-transplant mortality, but its assessment tools are not yet accepted.

    “Frailty, defined as a generalized vulnerability to stressors resulting from the presence of multiple physiologic deficits, is associated with an increased risk of waitlist and post-transplant mortality.(51–53)”

    From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [52]

    The Introduction defines frailty as reduced physiologic reserve and vulnerability to stressors, and the Discussion links it to waitlist and post-transplant mortality. The Discussion says frailty measures are not yet ready for incorporation into organ-allocation policy; it does not say the assessment tools themselves are unaccepted, and Methods calls two of them well validated. The printed citing sentence omits the assessment-tools assertion. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The paper says frailty is linked to higher waitlist and post-transplant mortality, but frailty measures are not yet settled for listing decisions.

    “Frailty, defined as a generalized vulnerability to stressors resulting from the presence of multiple physiologic deficits, is associated with an increased risk of waitlist and post-transplant mortality.(51–53) However, frailty in lung transplant candidates is often attributable to advanced lung disease and may improve following transplant.”

    From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [52]

  • Frailty is associated with an increased risk of waitlist and post-transplant mortality.

    “Frailty, defined as a generalized vulnerability to stressors resulting from the presence of multiple physiologic deficits, is associated with an increased risk of waitlist and post-transplant mortality.(51–53)”

    From Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. (2021) · cites this paper as [52]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [61]Singer JP Soong A Bruun A Hays S Kukreja J Bracha A Chin G Wolters PJ Peters M Garvey CM Pre-Habilitation” of Frail Candidates for Lung Transplantation Using a Mobile Health Enabled Home-Based Intervention Is Feasible and Safe Am J Resp Crit Care Med 2017 195 A2342 (abstract)

Cited by

Sorted by citations

Related

Authors
Singer, J. P., Diamond, J. M., Anderson, M. R., Katz, P. P., Covinsky, K., Oyster, M., Blue, T., Soong, A., Kalman, L., Shrestha, P., Arcasoy, S. M., Greenland, J. R., Shah, L., Kukreja, J., Blumenthal, N. P., Easthausen, I., Golden, J. A., McBurnie, A., Cantu, E., Sonett, J., Hays, S., Robbins, H., Raza, K., Bacchetta, M., Shah, R. J., D’Ovidio, F., Venado, A., Christie, J. D., & Lederer, D. J.
Affiliations
  • University of California, San Francisco (US)
  • University of Pennsylvania (US)
  • Columbia University (US)
Corresponding author
Singer, Jonathan P.
ORCID
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2018-08
Volume
18
Issue
8
Pages
1995-2004
ISSN
1600-6135 (ISSN-L)
DOI
10.1111/ajt.14873
PMC
PMC6105397
OpenAlex
W2802125047
Semantic Scholar
2ab79f813a0007b477cefdab6f1e699642ad8d34
Cited by
133
References
62
Citations by year
2026: 10 · 2025: 14 · 2024: 10 · 2023: 28 · 2022: 18 · 2021: 13 · 2020: 24 · 2019: 11 · 2018: 4 · 2017: 1
FWCI
13.51
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders
  • National Heart, Lung, and Blood Institute (K23 HL111115, R01 HL134851, K23 HL121406, K23 HL116656, R03 HL135227, R01 HL081619, HL096845, HL115354, HL087115, R01 HL114626, K24 HL131937)
  • Nina Ireland Program in Lung Health Award
  • National Center for Advancing Translational Sciences (UCSF-CTSI UL1 RR024131, CUMC-CTSA UL1 TR000040)
  • Rocco Guinta Research Fund
Topics
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
frailty, lung transplantation, postoperative mortality, Short Physical Performance Battery, Fried frailty phenotype, preoperative frailty, transplant outcomes
MeSH terms
Frailty, Aged, Female, Follow-Up Studies, Humans, Lung Diseases, Male, Middle Aged, Phenotype, Postoperative Complications, Prognosis, Prospective Studies, Quality of Life, Risk Factors, Severity of Illness Index, Survival Rate, Lung Transplantation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review