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Cited by 270Frailty in Older AdultsHormonal and reproductive studiesGrowth Hormone and Insulin-like Growth Factors

Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty

Leng, Sean X., Cappola, Anne R., Andersen, Ross E., Blackman, Marc R., Koenig, Kathleen, Blair, Michael, Walston, Jeremy D.·2004·Aging Clinical and Experimental Research
DOI 10.1007/bf03324545
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Abstract

Background and aims The geriatric syndrome of frailty has been conceptualized as a loss of physiologic reserve associated with endocrine dysregulation and immune dysfunction. Our prior studies suggest that the frailty syndrome is associated with elevated serum IL-6 levels. In the present study, our aim is to evaluate the possible role of endocrine dysregulation and its relationship with serum IL-6 in the pathogenesis of this syndrome.Methods Using a recently validated screening algorithm for frailty, we identified 18 frail and 33 non-frail community-dwelling older adults for inclusion in this study. Serum levels of insulin-like growth factor-I (IGF-I), DHEA-S, and IL-6 were measured by immunoassays. The inter-relationships among serum levels of IL-6, DHEA-S, and IGF-I were determined by linear regression analysis.Results Age-adjusted serum levels of IGF-I (88+/-49 vs 122+/-47 [ng/mL], p<0.023) and DHEA-S (0.30+/-0.21 vs 0.53+/-0.25 [microg/mL], p=0.016) were significantly lower in frail vs non-frail individuals, respectively. There was a trend for IL-6 to be inversely correlated with IGF-I in the frail (r=-0.42; p=0.082) but not the non-frail group (r=0.12, p=0.521).Conclusions Frail subjects have lower levels of serum IGF-I and DHEA-S and higher levels of IL-6 than do non-frail, age-matched individuals. The trend toward an inverse correlation between IGF-I and IL-6 in the frail, but not the non-frail group, suggests potential interaction between endocrine and immune/cytokine dysregulation that requires further study in larger cohorts.

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  • A cross-sectional study reported lower IGF-1 concentrations in frail individuals than in age-matched controls.

    “One cross-sectional study reported significantly lower levels of IGF-1 in people identified as frail when compared to age-matched controls (36).”

    From Frailty in elderly people (2013) · cites this paper as [36]

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Authors
Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D.
Affiliations
  • Johns Hopkins University (US)
  • University of Pennsylvania (US)
  • National Institutes of Health (US)
Corresponding author
Walston, Jeremy D.
ORCID
Venue
Aging Clinical and Experimental Research
Publisher
Springer Science and Business Media LLC
Published
2004-04
Volume
16
Issue
2
Pages
153-157
ISSN
  • 1594-0667 (ISSN-L)
  • 1720-8319
DOI
10.1007/bf03324545
OpenAlex
W2090523257
Cited by
270
References
33
Citations by year
2026: 6 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 19 · 2021: 11 · 2020: 20 · 2019: 16 · 2018: 17 · 2017: 15 · 2016: 19 · 2015: 13 · 2014: 22 · 2013: 9 · 2012: 6
FWCI
3.38
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Aging Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Center for Research Resources (M01RR002719, M0-1-RR-02719)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
frailty, geriatric syndromes, insulin-like growth factor I, dehydroepiandrosterone sulfate, interleukin-6, endocrine dysfunction, immune dysfunction, cytokines, older adults, physiological reserve
MeSH terms
Aged, Aged, 80 and over, Analysis of Variance, Body Composition, Female, Humans, Insulin-Like Growth Factor I, Male, Sex Factors, Syndrome, Geriatric Assessment, Interleukin-6, Body Mass Index, Linear Models, Frail Elderly, Statistics, Nonparametric, Wasting Syndrome, Dehydroepiandrosterone Sulfate, White People

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