In vivo diagnosis of allergic diseases-allergen provocation tests
Open accessAbstract
The allergen challenge test has been the mainstay of diagnosis of allergic diseases for a long time since it offers a direct proof of the clinical relevance of a particular allergen for the allergic disease symptoms and severity. Standardisation and availability for daily practice (including safety issues) are still to be refined but most of the challenge tests have safely crossed the border from research tools to diagnostic tests available for daily practice for a well trained clinical staff.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nasal provocation testing is designed for allergic rhinitis, while conjunctival provocation testing may be used in patients with rhinoconjunctivitis or allergic rhinitis alone.
“The NPT is designed for AR, while conjunctival provocation test (CPT) may be used in patients with rhinoconjunctivitis or AR alone.1069,1070”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1069]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,997 · see citing works
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729 · see citing works
Self-citationAllergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588 · see citing works
EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy
Muraro, A. M., Werfel, T., Hoffmann‐Sommergruber, K., Roberts, G. C., Beyer, K., Bindslev‐Jensen, C., Cardona, V., Dubois, A. E. J., Toit, G. D., Eigenmann, P., et al. (2014) · Allergy · doi:10.1111/all.12429 · Cited by 1,407 · see citing works
Self-citationInternational Con sensus on drug allergy
Demoly, P. M., Adkinson, N. F., Brockow, K., Castells, M., Chiriac, A. M., Greenberger, P. A., Khan, D. A., Lang, D. M., Park, H., Pichler, W. J., et al. (2014) · Allergy · doi:10.1111/all.12350 · Cited by 932 · see citing works
Self-citationDrug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations
Aberer, W., Bircher, A. J., Romano, A. G., et al. (2003) · Allergy · doi:10.1034/j.1398-9995.2003.00279.x · Cited by 824 · see citing works
Sampson, H. A., van Wijk, R. G., Bindslev‐Jensen, C., Sicherer, S. H., Teuber, S. S., Burks, A. W., Dubois, A. E. J., Beyer, K., Eigenmann, P., Spergel, J. M., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.10.017 · Cited by 751 · see citing works
Self-citationBindslev‐Jensen, C., Ballmer-Weber, B. K., Bengtsson, U. J., Blanco, C., Ebner, C., Hourihane, J. O., Knulst, A. C., Moneret‐Vautrin, D. A., Nékám, K., Niggemann, B., et al. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00466.x · Cited by 682 · see citing works
Self-citationDiagnosis of Hymenoptera venom allergy
Bilò, M. B., Ruëff, F., Mosbech, H., Bonifazi, F., Oude-Elberink, J. N. G., & the EAACI Interest Group on Insect Venom Hypersensitivity (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00963.x · Cited by 563 · see citing works
Self-citationDiagnosis of immediate allergic reactions to beta‐lactam antibiotics
Torres, M. J., Blanca, M., Fernández, J., Romano, A. G., Weck, A. D., Aberer, W., Brockow, K., Pichler, W. J., Demoly, P. M., for, E. N. D. A., et al. (2003) · Allergy · doi:10.1034/j.1398-9995.2003.00280.x · Cited by 522 · see citing works
Self-citationKowalski, M. L., Asero, R., Bavbek, S., Blanca, M., Blanca‐López, N., Bochenek, G., Brockow, K., Campo, P., Celik, G., Cernadas, J., et al. (2013) · Allergy · doi:10.1111/all.12260 · Cited by 501 · see citing works
Self-citationKowalski, M. L., Makowska, J. S., Blanca, M., et al. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02557.x · Cited by 467 · see citing works
Update on the evaluation of hypersensitivity reactions to betalactams
Blanca, M., Romano, A. G., Torres, M. J., Fernández, J., Mayorga, C., Rodriguez, J., Demoly, P. M., Bousquet, P., Merk, H. F., Sanz, M. L., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2008.01924.x · Cited by 450 · see citing works
Self-citationEAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
Niżankowska‐Mogilnicka, E., Bochenek, G., Mastalerz, L., Świerczyńska, M., Picado, C., Scadding, G. K., Kowalski, M. L., Setkowicz, M., Ring, J., Brockow, K., et al. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01409.x · Cited by 404 · see citing works
Diagnosis of nonimmediate reactions to β‐lactam antibiotics
Romano, A. G., Blanca, M., Torres, M. J., et al. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00678.x · Cited by 348 · see citing works
Caubet, J., Kaiser, L., Lemaître, B., Fellay, B., Gervaix, A., & Eigenmann, P. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.025 · Cited by 343 · see citing works
Self-citationManagement of hypersensitivity reactions to iodinated contrast media
Brockow, K., Christiansen, C., Kanny, G., et al. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00745.x · Cited by 301 · see citing works
Conjunctival Allergen Challenge
Abelson, M. B. (1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070030090035 · Cited by 286 · see citing works
Local allergic rhinitis: Concept, pathophysiology, and management
Rondón, C., Campo, P., Togias, A., Fokkens, W. J., Durham, S. R., Powe, D. G., Mullol, J., & Blanca, M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.02.032 · Cited by 280 · see citing works
Stinging insect hypersensitivity: A practice parameter update 2011
Golden, D. B. K., Moffitt, J. E., Nicklas, R. A., Freeman, T. M., Graft, D. F., Reisman, R. E., Tracy, J. M., Bernstein, D., Blessing-Moore, J., Cox, L., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.025 · Cited by 264 · see citing works
Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface
Leonardi, A., Bogacka, E., Fauquert, J., Kowalski, M. L., Groblewska, A., Jędrzejczak-Czechowicz, M., Doan, S., Marmouz, F., Demoly, P. M., & Delgado, L. (2012) · Allergy · doi:10.1111/all.12009 · Cited by 250 · see citing works
Self-citationMasthoff, L. J. N., Mattsson, L., Zuidmeer, L., Lidholm, J., Andersson, K. M., Akkerdaas, J. H., Versteeg, S. A., Garino, C., Meijer, Y., Kentie, P. A., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.024 · Cited by 237 · see citing works
Cockcroft, D. W. (2010) · CHEST Journal · doi:10.1378/chest.10-0088 · Cited by 222 · see citing works
Diagnostic tools in Rhinology EAACI position paper
Scadding, G., Hellings, P., Alobid, I., Bachert, C., Fokkens, W., van Wijk, R. G., Gevaert, P., Guilemany, J., Kalogjera, L., Lund, V., et al. (2011) · Clinical and Translational Allergy · doi:10.1186/2045-7022-1-2 · Cited by 220 · see citing works
Self-citationEczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN
Werfel, T., Ballmer-Weber, B. K., Eigenmann, P., Niggemann, B., Rancé, F., Turjanmaa, K., & Worm, M. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01429.x · Cited by 196 · see citing works
Self-citationNicolaou, N. C., Murray, C. S., Belgrave, D. C. M., Poorafshar, M., Simpson, A., & Čustović, A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.012 · Cited by 185 · see citing works
Anderson, S. D. (2010) · CHEST Journal · doi:10.1378/chest.10-0116 · Cited by 167 · see citing works
Ruëff, F., Bernhard Przybilla, A., Müller, U., & Mosbech, H. (1996) · Allergy · doi:10.1111/j.1398-9995.1996.tb04596.x · Cited by 162 · see citing works
Determining the negative predictive value of provocation tests with beta‐lactams
Demoly, P. M., Romano, A. G., Botelho, C., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02228.x · Cited by 133 · see citing works
Self-citationA systematic review of the diagnosis of occupational asthma
Beach, J., Russell, K., Blitz, S., Hooton, N., Spooner, C., Lemiere, C., Tarlo, S. M., & Rowe, B. H. (2007) · Chest · doi:10.1378/chest.06-0492 · Cited by 128 · see citing works
Highly accurate prediction of food challenge outcome using routinely available clinical data
DunnGalvin, A., Daly, D., Cullinane, C., Stenke, E., Keeton, D., Erlewyn‐Lajeunesse, M., Roberts, G. C., Lucas, J. S., & Hourihane, J. O. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.12.004 · Cited by 122 · see citing works
Inhaled allergen bronchoprovocation tests
Diamant, Z., Gauvreau, G. M., Cockcroft, D., Boulet, L., Sterk, P. J., de Jongh, F. H., Dahlén, B., & O’Byrne, P. M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.08.023 · Cited by 116 · see citing works
Torres, M. J., Gómez, F., Doña, I., et al. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02840.x · Cited by 108 · see citing works
Ponvert, C., Weilenmann, C., Wassenberg, J., et al. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01246.x · Cited by 104 · see citing works
Allergen dose response and late symptoms in a human model of ocular allergy
Bonini, S., Bonini, S., Bucci, M. G., Berruto, A., Adriani, E., BALSANO, F., & Allansmith, M. R. (1990) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(05)80148-4 · Cited by 99 · see citing works
Provoked models of asthma: what have we learnt?
O’Byrne, P. M., Gauvreau, G. M., & Brannan, J. D. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03172.x · Cited by 95 · see citing works
Benhamou, A. H., Zamora, S. A., & Eigenmann, P. (2008) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00602.x · Cited by 86 · see citing works
Self-citationNasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis
Segboer, C. L., Holland, C. T., Reinartz, S. M., Terreehorst, I., Gevorgyan, A., Hellings, P. W., van Drunen, C. M., & Fokkens, W. J. (2013) · Allergy · doi:10.1111/all.12255 · Cited by 84 · see citing works
Self-citationPredicting Outcomes of Oral Food Challenges by Using the Allergen-Specific IgE–Total IgE Ratio
Gupta, R. S., Lau, C. H., Hamilton, R. G., Donnell, A. T., & Newhall, K. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2013.12.006 · Cited by 82 · see citing works
Provocation Tests in Diagnosing Drug Hypersensitivity
Bousquet, P., Gaeta, F., Bousquet-Rouanet, L., et al. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786369731 · Cited by 70 · see citing works
Hohlfeld, J. M., Holland‐Letz, T., Larbig, M., Lavae‐Mokhtari, M., Wierenga, E., Kapsenberg, M., Van Ree, R., Krug, N., & Bufe, A. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03498.x · Cited by 69 · see citing works
Comparison of Conjunctival and Nasal Provocation Test in Allergic Rhinitis to House Dust Mite
Riechelmann, H., Epple, B., & Gropper, G. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000068369 · Cited by 62 · see citing works
Leonardi, A. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80315-6 · Cited by 61 · see citing works
One-week Oral Challenge with Penicillin in Diagnosis of Penicillin Allergy
Hjortlund, J., Mortz, C. G., Skov, P. S., et al. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1254 · Cited by 60 · see citing works
Devillier, P., Gall, M. L., & Horak, F. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02473.x · Cited by 58 · see citing works
Self-citationDay, J. H., Horak, F., Briscoe, M. P., Canonica, G. W., Fìneman, S. M., Krug, N., Leynadier, F., Lieberman, P., Quirce, S., Takenaka, H., et al. (2006) · Clinical & Experimental Allergy Reviews · doi:10.1111/j.1365-2222.2005.00099.x · Cited by 57 · see citing works
Self-citationFacial thermography is a sensitive and specific method for assessing food challenge outcome
Clark, A. T., Mangat, J., Tay, S. S., et al. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01363.x · Cited by 45 · see citing works
Defrance, C., Bousquet, P., & Demoly, P. M. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02671.x · Cited by 45 · see citing works
Self-citationThe impact of oral food challenge tests on food allergy health‐related quality of life
Soller, L., Hourihane, J., & DunnGalvin, A. (2014) · Allergy · doi:10.1111/all.12442 · Cited by 45 · see citing works
The Influence of the Presence of Wheat Flour on the Antigenic Activities of Egg White Proteins
Shin, M., Lee, J., Ahn, K., Lee, S. I., & Han, Y. (2012) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2013.5.1.42 · Cited by 45 · see citing works
Are specific immunoglobulin E titres reliable for prediction of food allergy?
Eigenmann, P. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02183.x · Cited by 39 · see citing works
Self-citationBronchial allergen challenges in children – safety and predictors
Schulze, J., Reinmüller, W., Herrmann, E. M., Rosewich, M., Rose, M. A., & Zielen, S. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12031 · Cited by 32 · see citing works
Diagnosis of Occupational Asthma: An Update
Jares, E. J., Baena‐Cagnani, C. E., & Gómez, R. M. (2012) · Current Allergy and Asthma Reports · doi:10.1007/s11882-012-0259-2 · Cited by 27 · see citing works
Comparison of incremental and bolus dose inhaled allergen challenge in asthmatic patients
Taylor, Harris, & O’Connor (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00657.x · Cited by 25 · see citing works
Mortemousque, B., Fauquert, J., Chiambaretta, F., Demoly, P. M., Helleboid, L., Creuzot-Garcher, C. P., & Brémond‐Gignac, D. (2006) · Journal Français d Ophtalmologie · doi:10.1016/s0181-5512(06)73857-8 · Cited by 23 · see citing works
Self-citationPatients’ Satisfaction with Diagnostic Drug Provocation Tests and Perception of Its Usefulness
Gomes, E. R., Kvedarienė, V., Demoly, P. M., et al. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000323898 · Cited by 22 · see citing works
Self-citationBernstein, J. A. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.032 · Cited by 22 · see citing works
Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis
Doğan, S., Astvatsatourov, A., Deserno, T. M., Bock, F., Shah‐Hosseini, K., Michels, A., & Mösges, R. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000355333 · Cited by 21 · see citing works
Objective measurement of allergic reactions in the eye
Friedlaender, M. H. (2004) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200410000-00019 · Cited by 17 · see citing works
The value of mucosal allergen challenge for the diagnosis of food allergy
Kvenshagen, B. K., & Jacobsen, M. (2013) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32836093f6 · Cited by 12 · see citing works
Evaluation and validation of a bee venom sting challenge performed by a micro-syringe
Cortellini, G., Severino, M. G., Francescato, E., et al. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.09.003 · Cited by 10 · see citing works
Is 30 minutes between doses long enough in oral food challenges?
Pettersson, M. E., Blok, B. M. J. F.-D., der Heide, S. V., et al. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12256 · Cited by 8 · see citing works
Chandra, R., Chiu, A., Carr, W., & Settipane, R. (2013) · American Journal of Rhinology and Allergy · doi:10.2500/ajra.2013.27.3933 · Cited by 8 · see citing works
Pelikan, Z. (2013) · Current Eye Research · doi:10.3109/02713683.2013.836542 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [4]4. Pelikan Z. Cytological changes in nasal secretions accompanying delayed nasal response to allergen challenge. Am J Rhinol Allergy 2013; 27 :345 -353.
Cited by
Sorted by citations
EAACI Molecular Allergology User's Guide
Matricardi, P. M., Kleine‐Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R. C., Agache, I., Asero, R., Ballmer‐Weber, B., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12563 · Cited by 932 · see citing works
Self-citationInternational Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works
Shamji, M. H., Kappen, J. H., Akdis, M., Jensen‐Jarolim, E., Knol, E. F., Kleine‐Tebbe, J., Bohle, B., Chaker, A. M., Till, S. J., Valenta, R., et al. (2017) · Allergy · doi:10.1111/all.13138 · Cited by 382 · see citing works
Self-citationOttaviano, G., & Fokkens, W. J. (2016) · Allergy · doi:10.1111/all.12778 · Cited by 160 · see citing works
- Authors
- Agache, I., Bilò, M., Braunstahl, G.-J., Delgado, L., Demoly, P., Eigenmann, P., Gevaert, P., Gomes, E., Hellings, P., Horak, F., Muraro, A., Werfel, T., & Jutel, M.
- Affiliations
- Transilvania University of Brașov (RO)
- Internal Medicine; Allergy Unit; Ancona Italy
- Sint Franciscus Gasthuis (NL)
- Universidade do Porto (PT)
- Centre Hospitalier Universitaire de Montpellier (FR)
- University Hospital of Geneva (CH)
- Ghent University (BE)
- Hospital Maria Pia (PT)
- Universitair Ziekenhuis Leuven (BE)
- Allergiezentrum Wien West (AT)
- Azienda Ospedale - Università Padova (IT)
- Medizinische Hochschule Hannover (DE)
- Wroclaw Medical University (PL)
- Corresponding author
- Agache, I.
- ORCID
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2015-02-12
- Volume
- 70
- Issue
- 4
- Pages
- 355-365
- ISSN
- 0105-4538 (ISSN-L)
- OpenAlex
- W2040904567
- Cited by
- 104
- References
- 64
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 6 · 2015: 6 · 2013: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Lirias (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- allergen provocation test, allergen challenge, allergic diseases, in vivo diagnosis, test standardization, test safety
- MeSH terms
- Allergens, Animals, Bites and Stings, Bronchial Provocation Tests, Drug Hypersensitivity, Food, Food Hypersensitivity, Humans, Hypersensitivity, Nasal Provocation Tests, Skin Tests, Venoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
