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Cited by 38Dermatology and Skin DiseasesFood Allergy and Anaphylaxis ResearchContact Dermatitis and Allergies

The skin microbiome in pediatric atopic dermatitis and food allergy

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Tham, Elizabeth Huiwen, Chia, Minghao, Riggioni, Carmen, Nagarajan, Niranjan, Common, John E. A., Kong, Heidi H.·2024·Allergy
DOI 10.1111/all.16044PMC PMC11142881

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Abstract

The skin microbiome is an extensive community of bacteria, fungi, mites, viruses and archaea colonizing the skin. Fluctuations in the composition of the skin microbiome have been observed in atopic dermatitis (AD) and food allergy (FA), particularly in early life, established disease, and associated with therapeutics. However, AD is a multifactorial disease characterized by skin barrier aberrations modulated by genetics, immunology, and environmental influences, thus the skin microbiome is not the sole feature of this disease. Future research should focus on mechanistic understanding of how early‐life skin microbial shifts may influence AD and FA onset, to guide potential early intervention strategies or as microbial biomarkers to identify high‐risk infants who may benefit from possible microbiome‐based biotherapeutic strategies. Harnessing skin microbes as AD biotherapeutics is an emerging field, but more work is needed to investigate whether this approach can lead to sustained clinical responses.

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  • In a murine model, skin colonized by S. aureus leads to activation of dermal antigen-presenting cells after exposure of inflamed skin to exogenous food allergens, expansion of germinal center IgE+ B cells, generation of IgE specific to food allergens, and inflammatory cytokines.

    “In a murine model, skin colonized by S. aureus leads to the activation of dermal antigen-presenting cells after exposure of inflamed skin to exogenous food allergens, expansion of germinal center IgE + B cells, and generation of IgE specific to food allergens, in addition to inflammatory cytokines (IL-4, IL-5, thymic stromal lymphopoietin (TSLP) and IL-33).”

    From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [12]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

  • Epicutaneous exposure combined with staphylococcal enterotoxin B increased allergenic responses to eggs and peanuts.

    “it was demonstrated that epicutaneous exposure combined with staphylococcal enterotoxin B increased allergenic responses to eggs and peanuts.”

    From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [12]

    The review reports that combined epicutaneous exposure to staphylococcal enterotoxin B and ovalbumin increased ovalbumin-specific antibodies in a murine model. It also reports increased peanut-specific Th2 responses in mice exposed to the toxin and peanut extract. The claim omits that these were mouse experiments and describes the ovalbumin result more broadly as a response to eggs. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Cutaneous microbial dysbiosis contributes to barrier dysfunction, modulating allergic sensitization.

    “Thus, cutaneous microbial dysbiosis also contributes to barrier dysfunction, modulating allergic sensitization.”

    From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [12]

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Sorted by citations

Authors
Tham, E. H., Chia, M., Riggioni, C., Nagarajan, N., Common, J. E. A., & Kong, H. H.
Affiliations
  • National University of Singapore (SG)
  • Agency for Science, Technology and Research (SG)
  • National Institutes of Health (US)
Corresponding author
Tham, Elizabeth Huiwen
ORCID
Venue
Allergy
Publisher
Wiley
Published
2024-02-03
Volume
79
Issue
6
Pages
1470-1484
ISSN
  • 0105-4538 (ISSN-L)
  • 1398-9995
DOI
10.1111/all.16044
PMC
PMC11142881
OpenAlex
W4391514378
Cited by
38
References
8
Citations by year
2026: 14 · 2025: 15 · 2024: 9
FWCI
2.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Allergy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
Funders
  • Agency for Science, Technology and Research
  • National Institutes of Health
  • National Medical Research Council
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
skin microbiome, atopic dermatitis, food allergy, pediatric allergy, skin barrier dysfunction, microbial biomarkers, high-risk infants, early intervention
MeSH terms
Child, Dermatitis, Atopic, Food Hypersensitivity, Humans, Skin, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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