The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype
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Patients with atopic dermatitis and food allergy have an immature epithelial barrier and type 2 immune activation in their skin.
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Epithelial barrier dysfunction induces type 2 immune responses and is considered an initial step in developing AD and the atopic march.
“Epithelial barrier dysfunction induces type 2 immune responses and is considered an initial step in developing atopic dermatitis (AD) and the atopic march (14, 16, 17).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [17]
The Discussion reports that skin disruption induces cytokines that drive type 2 responses in mouse models, and it supports a role for the skin barrier in AD and food allergy. But it says the relationships may be multidirectional and that human intervention studies are needed to establish causality. The Introduction describes the atopic march without identifying barrier dysfunction as its initial step; the claim states that sequence more definitively than this paper does (page numbers unavailable). (LLM, conf=0.86)
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“dermatitis (AD) and the atopic march (14, 16, 17).”
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Atopy: A Collection of Comorbid Conditions
Diaz-Cabrera, N. M., Sánchez‐Borges, M., & Ledford, D. K. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.09.002 · Cited by 20 · see citing works
- Authors
- Leung, D. Y. M., Calatroni, A., Zaramela, L. S., LeBeau, P. K., Dyjack, N., Brar, K., David, G., Johnson, K., Leung, S., Ramirez-Gama, M., Liang, B., Rios, C., Montgomery, M. T., Richers, B. N., Hall, C. F., Norquest, K. A., Jung, J., Bronova, I., Kreimer, S., Conover Talbot, C., Crumrine, D., Cole, R. N., Elias, P., Zengler, K., Seibold, M. A., Berdyshev, E., & Goleva, E.
- Affiliations
- National Jewish Health (US)
- Rho (United States) (US)
- University of California San Diego (US)
- Johns Hopkins University (US)
- Johns Hopkins University, Baltimore, MD 21218, USA.
- University of California, San Francisco (US)
- Corresponding author
- Leung, Donald Y. M.
- ORCID
- Leung, Donald Y. M.
- Calatroni, Agustin
- Zaramela, Livia S.
- LeBeau, Petra K.
- Dyjack, Nathan
- Brar, Kanwaljit
- David, Gloria
- Ramirez-Gama, Marco
- Liang, Bo
- Montgomery, Michael T.
- Hall, Clifton F.
- Norquest, Kathryn A.
- Jung, John
- Bronova, Irina
- Kreimer, Simion
- Conover Talbot, C.
- Crumrine, Debra
- Cole, Robert N.
- Elias, Peter
- Zengler, Karsten
- Seibold, Max A.
- Berdyshev, Evgeny
- Goleva, Elena
- Venue
- Science Translational Medicine
- Published
- 2019-02-20
- Volume
- 11
- Issue
- 480
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7676854
- OpenAlex
- W2916319738
- Cited by
- 214
- References
- 75
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 38 · 2023: 29 · 2022: 29 · 2021: 37 · 2020: 39 · 2019: 12
- FWCI
- 29.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NIAID Atopic Dermatitis Research Network (U19AI117673, UM2AI117870)
- NIH/NCATS Colorado CTSA (UL1 TR002535)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic dermatitis, food allergy, endotypes, non-lesional skin, skin barrier, Th2 immune response, epithelial barrier function
- MeSH terms
- Filaggrin Proteins, Adolescent, Child, Child, Preschool, Dendritic Cells, Dermatitis, Atopic, Epidermis, Food Hypersensitivity, Humans, Intermediate Filament Proteins, Keratins, Lipids, Skin, Water Loss, Insensible, Area Under Curve, Surgical Tape, Transcriptome, Microbiota
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