Cited by 214Dermatology and Skin DiseasesFood Allergy and Anaphylaxis ResearchContact Dermatitis and Allergies

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype

Open access
Leung, Donald Y. M., Calatroni, Agustin, Zaramela, Livia S., LeBeau, Petra K., Dyjack, Nathan, Brar, Kanwaljit, David, Gloria, Johnson, Keli +19 more·2019·Science Translational Medicine

Abstract

Patients with atopic dermatitis and food allergy have an immature epithelial barrier and type 2 immune activation in their skin.

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Registry

Crossref · 10.1126/scitranslmed.aav2685

Cites

75 of 75 references verified0 citation errors · 0 not checkable

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  • Epithelial barrier dysfunction induces type 2 immune responses and is considered an initial step in developing AD and the atopic march.

    “Epithelial barrier dysfunction induces type 2 immune responses and is considered an initial step in developing atopic dermatitis (AD) and the atopic march (14, 16, 17).”

    From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [17]

    The Discussion reports that skin disruption induces cytokines that drive type 2 responses in mouse models, and it supports a role for the skin barrier in AD and food allergy. But it says the relationships may be multidirectional and that human intervention studies are needed to establish causality. The Introduction describes the atopic march without identifying barrier dysfunction as its initial step; the claim states that sequence more definitively than this paper does (page numbers unavailable). (LLM, conf=0.86)

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Cites

2 retracted

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Research works printed but not linked: 1

  1. [61]Sarkar D, Lattice: Multivariate Data Visualization with R (Springer, 2008).

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Authors
Leung, D. Y. M., Calatroni, A., Zaramela, L. S., LeBeau, P. K., Dyjack, N., Brar, K., David, G., Johnson, K., Leung, S., Ramirez-Gama, M., Liang, B., Rios, C., Montgomery, M. T., Richers, B. N., Hall, C. F., Norquest, K. A., Jung, J., Bronova, I., Kreimer, S., Conover Talbot, C., Crumrine, D., Cole, R. N., Elias, P., Zengler, K., Seibold, M. A., Berdyshev, E., & Goleva, E.
Affiliations
  • National Jewish Health (US)
  • Rho (United States) (US)
  • University of California San Diego (US)
  • Johns Hopkins University (US)
  • Johns Hopkins University, Baltimore, MD 21218, USA.
  • University of California, San Francisco (US)
Corresponding author
Leung, Donald Y. M.
Venue
Science Translational Medicine
Published
2019-02-20
Volume
11
Issue
480
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2916319738
Cited by
214
References
75
Citations by year
2026: 10 · 2025: 19 · 2024: 38 · 2023: 29 · 2022: 29 · 2021: 37 · 2020: 39 · 2019: 12
FWCI
29.47
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH/NIAID Atopic Dermatitis Research Network (U19AI117673, UM2AI117870)
  • NIH/NCATS Colorado CTSA (UL1 TR002535)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
atopic dermatitis, food allergy, endotypes, non-lesional skin, skin barrier, Th2 immune response, epithelial barrier function
MeSH terms
Filaggrin Proteins, Adolescent, Child, Child, Preschool, Dendritic Cells, Dermatitis, Atopic, Epidermis, Food Hypersensitivity, Humans, Intermediate Filament Proteins, Keratins, Lipids, Skin, Water Loss, Insensible, Area Under Curve, Surgical Tape, Transcriptome, Microbiota

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