Children and adolescents with type 1 diabetes and high HbA1c -- a neurodevelopmental perspective
Abstract
Aim: To examine the association between neurodevelopmental problems and high HbA1c among paediatric patients with type 1 diabetes. Methods: A population‐based study was performed among patients with type 1 diabetes (5–16 years) in two Swedish counties (n = 233). The Five to Fifteen (FTF) questionnaire targeted neurodevelopmental qualities. Scores above the 90th percentile in the various domains are considered as definitive problems and scores above the 75th percentile as mild. FTF scores were compared with regard to HbA1c ≤73 mmol/mol and >73 mmol/mol (8.0%). Results: The response rate was 190 (82%). Neurodevelopmental problems were not overrepresented among patients in general. Memory and learning problems were associated with HbA1c >73 mmol/mol (p = 0.01). This correlation was especially seen in adolescents (12–16 years) where mild executive problems (adj OR 3.1), definite memory problems (adj OR 5.0) and definite learning problems (adj OR 5.0) were associated with HbA1c >73 mmol/mol after adjustment for gender, diabetes duration and age of onset. Conclusion: Our findings that high HbA1c is more common in adolescent diabetes patients with neurodevelopmental problems generate the hypothesis that these problems might precede poor metabolic control. If so, early detection of neurodevelopmental problems would allow individually tailored treatment that may improve metabolic control and prevent complications.
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Noncompliance and persistent high level of glycated hemoglobin in type 1 diabetes is a risk factor for psychiatric comorbidity and neurodevelopmental problems.
“Noncompliance and persistent high level of glycated hemoglobin in type 1 diabetes is a risk factor for psychiatric comorbidity and neurodevelopmental problems (28,30,31).”
From Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study (2015) · cites this paper as [28]
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- Authors
- Nylander, C., Toivonen, H., Nasic, S., Söderström, U., Tindberg, Y., & Fernell, E.
- Affiliations
- Uppsala University (SE)
- Skaraborg Hospital (SE)
- Corresponding author
- Nylander, Charlotte
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2013-01-19
- Volume
- 102
- Issue
- 4
- Pages
- 410-415
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2171003143
- Cited by
- 19
- References
- 31
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 1 diabetes, HbA1c, neurodevelopmental problems, pediatric diabetes, adolescents, memory impairment, learning difficulties, executive function, metabolic control, early detection
- MeSH terms
- Adolescent, Age Factors, Child, Developmental Disabilities, Child, Preschool, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Learning Disabilities, Male, Memory Disorders, Population Surveillance, Surveys and Questionnaires, Sweden, Age of Onset, Motor Skills Disorders, Early Diagnosis, Diabetes Complications, Executive Function
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