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Cited by 30Probiotics and Fermented FoodsInfant Nutrition and HealthGut microbiota and health

Rapid review shows that probiotics and fermented infant formulas do not cause d‐lactic acidosis in healthy children

Łukasik, J, Salminen, S, Szajewska, H·2018·Acta Paediatrica
DOI 10.1111/apa.14338
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Abstract

Aim: Extensive ongoing research on probiotics and infant formulas raises a number of safety questions. One concern is the potential influence of d‐lactic acid‐containing preparations on the health of infants and children. The aim of this review was to summarise the available knowledge on the ingestion of d‐lactic acid‐producing bacteria, acidified infant formulas and fermented infant formulas as a potential cause of paediatric d‐lactic acidosis. Methods: A Medline database search was performed in July 2017, with no restrictions on the language, article type or publication date. The 1715 search results were screened for clinical trials, review articles, case series and case reports of relevance to the topic. Results: We identified five randomised controlled trials from 2005 to 2017 covering 544 healthy infants and some case reports and experimental studies. No clinically relevant adverse effects of d‐lactic acid‐producing probiotics and fermented infant formulas were described in healthy children. However, a harmless, subclinical accumulation of d‐lactate was theoretically possible. The only known cases of paediatric d‐lactic acidosis occurred in patients with short bowel syndrome or, historically, in infants fed with acidified formulas. Conclusion: Our main finding was that probiotics and fermented formulas did not cause d‐lactic acidosis in healthy children.

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  • Lack of data in preterm infants led to a caution about using D-lactate-producing probiotics in this population, although a controlled trial in healthy full-term infants showed that D-lactate-producing L. reuteri DSM-17938 did not result in acidosis and probiotic-containing infant formulas were not associated with acidosis.

    “Lack of data in preterm infants led to a caution about using D-lactate-producing probiotics in this population,125 although a controlled trial in healthy full-term infants showed that D-lactate-producing L. reuteri DSM-17938 did not result in acidosis126 and probiotic-containing infant formulas were not associated with acidosis.127”

    From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [127]

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Authors
Łukasik, J., Salminen, S., & Szajewska, H.
Affiliations
  • Medical University of Warsaw (PL)
  • University of Turku (FI)
Corresponding author
Szajewska, H
ORCID
Venue
Acta Paediatrica
Publisher
Wiley
Published
2018-04-24
Volume
107
Issue
8
Pages
1322-1326
ISSN
  • 0365-1436 (ISSN-L)
  • 0803-5253
  • 1651-2227
DOI
10.1111/apa.14338
OpenAlex
W2795011776
Cited by
30
References
30
Citations by year
2026: 5 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 2
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Paediatrica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
D-lactic acidosis, probiotics, healthy infants, short bowel syndrome
MeSH terms
Infant Health, Acidosis, Lactic, Child, Preschool, Female, Fermentation, Humans, Infant, Male, Sensitivity and Specificity, Randomized Controlled Trials as Topic, Risk Assessment, Lactic Acid, Probiotics, Infant Formula

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